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A8A9W2

- RTCA_IGNH4

UniProt

A8A9W2 - RTCA_IGNH4

Protein

RNA 3'-terminal phosphate cyclase

Gene

rtcA

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.UniRule annotation

    Catalytic activityi

    ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001ATPUniRule annotation
    Active sitei315 – 3151Tele-AMP-histidine intermediateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi289 – 2924ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. RNA-3'-phosphate cyclase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciIHOS453591:GHYN-548-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA 3'-terminal phosphate cyclaseUniRule annotation (EC:6.5.1.4UniRule annotation)
    Short name:
    RNA cyclaseUniRule annotation
    Short name:
    RNA-3'-phosphate cyclaseUniRule annotation
    Gene namesi
    Name:rtcAUniRule annotation
    Ordered Locus Names:Igni_0532
    OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
    Taxonomic identifieri453591 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
    ProteomesiUP000000262: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 353353RNA 3'-terminal phosphate cyclasePRO_0000325190Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi453591.Igni_0532.

    Structurei

    3D structure databases

    ProteinModelPortaliA8A9W2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0430.
    HOGENOMiHOG000015264.
    KOiK01974.
    OMAiTTHIETC.

    Family and domain databases

    Gene3Di3.30.360.20. 1 hit.
    3.65.10.20. 2 hits.
    HAMAPiMF_00200. RTC.
    InterProiIPR013791. RNA3'-term_phos_cycl_insert.
    IPR023797. RNA3'_phos_cyclase_dom.
    IPR000228. RNA3'_term_phos_cyc.
    IPR017770. RNA3'_term_phos_cyc_type_1.
    IPR020719. RNA3'_term_phos_cycl-like_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view]
    PANTHERiPTHR11096. PTHR11096. 1 hit.
    PfamiPF01137. RTC. 1 hit.
    PF05189. RTC_insert. 1 hit.
    [Graphical view]
    SUPFAMiSSF52913. SSF52913. 1 hit.
    SSF55205. SSF55205. 1 hit.
    TIGRFAMsiTIGR03399. RNA_3prim_cycl. 1 hit.
    PROSITEiPS01287. RTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8A9W2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIEIDGSFGE GGGQILRTSV ALSAVTLKPV RIFNIRAKRK NPGLRRQHMV    50
    AVKALAEMTD AEVRGLELGS TEIVFIPKTL KAGTFRFDIG TAGSVSLVLQ 100
    AVTPAALFAP GEVRVQLRGG TDVPMSPPVD YLRFVFYPLL ERFGAKTELV 150
    LKRRGHYPKG GGEVEFASRP VDSLTQWGEV ERGEVLKVRG LSHCVKLPKH 200
    VAERQAKAAE EVLKKSGLKN VDIDLEWYPP ERDPHLGPGS GIVLWAITER 250
    SLLGADSLGA RGKRAERVGE EAARKLLEDL STGKALDRHM SDMIVPYVSL 300
    ACGRTEVGGA ALTMHAWTHV HVVKKFLPEL EVEISGELNK PFVMRVKGVC 350
    WQR 353
    Length:353
    Mass (Da):38,695
    Last modified:October 23, 2007 - v1
    Checksum:iF513232B42846DA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000816 Genomic DNA. Translation: ABU81714.1.
    RefSeqiYP_001435121.1. NC_009776.1.

    Genome annotation databases

    EnsemblBacteriaiABU81714; ABU81714; Igni_0532.
    GeneIDi5562318.
    KEGGiiho:Igni_0532.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000816 Genomic DNA. Translation: ABU81714.1 .
    RefSeqi YP_001435121.1. NC_009776.1.

    3D structure databases

    ProteinModelPortali A8A9W2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 453591.Igni_0532.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU81714 ; ABU81714 ; Igni_0532 .
    GeneIDi 5562318.
    KEGGi iho:Igni_0532.

    Phylogenomic databases

    eggNOGi COG0430.
    HOGENOMi HOG000015264.
    KOi K01974.
    OMAi TTHIETC.

    Enzyme and pathway databases

    BioCyci IHOS453591:GHYN-548-MONOMER.

    Family and domain databases

    Gene3Di 3.30.360.20. 1 hit.
    3.65.10.20. 2 hits.
    HAMAPi MF_00200. RTC.
    InterProi IPR013791. RNA3'-term_phos_cycl_insert.
    IPR023797. RNA3'_phos_cyclase_dom.
    IPR000228. RNA3'_term_phos_cyc.
    IPR017770. RNA3'_term_phos_cyc_type_1.
    IPR020719. RNA3'_term_phos_cycl-like_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view ]
    PANTHERi PTHR11096. PTHR11096. 1 hit.
    Pfami PF01137. RTC. 1 hit.
    PF05189. RTC_insert. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52913. SSF52913. 1 hit.
    SSF55205. SSF55205. 1 hit.
    TIGRFAMsi TIGR03399. RNA_3prim_cycl. 1 hit.
    PROSITEi PS01287. RTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIN4/I / DSM 18386 / JCM 14125.

    Entry informationi

    Entry nameiRTCA_IGNH4
    AccessioniPrimary (citable) accession number: A8A9W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3