A8A9W1 (AROC_IGNH4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	Igni_0531

Organism

Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]

Taxonomic identifier

453591 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Ignicoccus

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Chorismate synthase HAMAP MF_00300		PRO_1000022500

Sequences

	Sequence		Length	Mass (Da)
	A8A9W1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 6F01B350DFEC4C86	FASTA	380	40,952
	10 20 30 40 50 60 MGGNTIGKMF SVTTWGESHG KAIGAVIDGC PAGLPLSEED LLVELSLRRP GRRFTTPRRE 70 80 90 100 110 120 PDVPEILSGV FNGKTTGMPI SIIIRNRDVI SSYYEKIKET PRPGHADLAY IKKYGYEHWD 130 140 150 160 170 180 YRGGGRASGR ETAARVAAGA VAKKLLGCLG VVVSGYVVEL GGVEFPSAED AEESLRSRLS 190 200 210 220 230 240 PFRVLCCEEK AEEVLKEALE RRDSVGGVVE AVAWNAPAGL GEPVFDKLKA DLAKAMMSIP 250 260 270 280 290 300 ASVGFEVGWG FKLARLRGSE ARDKIVSSAG EATVEGDKAG GMLGGISVGA PIRIRVAFKP 310 320 330 340 350 360 TSSIMIPEKT VNIHTLEETE VEVPGRHDPA IVLRAVSVVE SMFAIVLVDH AIRAGLLNPV 370 380 RVEWGPHCQR VWELYADRVP

References

[1]

"A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans." Podar M., Anderson I., Makarova K.S., Elkins J.G., Ivanova N., Wall M.A., Lykidis A., Mavromatis K., Sun H., Hudson M.E., Chen W., Deciu C., Hutchison D., Eads J.R., Anderson A., Fernandes F., Szeto E., Lapidus A. , Kyrpides N.C., Saier M.H. Jr., Richardson P.M., Rachel R., Huber H., Eisen J.A., Koonin E.V., Keller M., Stetter K.O. Genome Biol. 9:R158.1-R158.18(2008) [PubMed: 19000309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIN4/I / DSM 18386 / JCM 14125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000816 Genomic DNA. Translation: ABU81713.1.
RefSeq	YP_001435120.1. NC_009776.1.
3D structure databases
ProteinModelPortal	A8A9W1.
ModBase	Search...
Protein-protein interaction databases
STRING	A8A9W1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5562364.
GenomeReviews	Gene locus Igni_0531 in contig CP000816_GR.
KEGG	iho:Igni_0531.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04618.
HOGENOM	HBG292336.
OMA	SRFTTQR.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	IHOS453591:IGNI_0531-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_IGNH4

Accession

Primary (citable) accession number: A8A9W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	November 16, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program