A8A909 (A8A909_IGNH4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224

Gene names

Name:	pyrD HAMAP MF_00224
Ordered Locus Names:	Igni_0227

Organism

Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]

Taxonomic identifier

453591 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Ignicoccus

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224
Catalytic activity	(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224
Cofactor	Binds 1 FMN per subunit By similarity. HAMAP MF_00224
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224
Subcellular location	Cytoplasm By similarity HAMAP MF_00224.
Sequence similarities	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis HAMAP MF_00224
Cellular component	Cytoplasm HAMAP MF_00224
Ligand	FMN HAMAP MF_00224 Flavoprotein HAMAP MF_00224
Molecular function	Oxidoreductase HAMAP MF_00224
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotate oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	129	1	Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

	Sequence		Length	Mass (Da)
	A8A909 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 336EBA4A0CB24A85	FASTA	302	31,071
	10 20 30 40 50 60 MLDLSADVGG LKLRLPLMPA SGILGGSPDA LEAVAKKAKV GALVTKTLTL EPRKGNDPPI 70 80 90 100 110 120 VVSTPCGLVN AVGLANPGVK VAKELVEVGR KYNLPVVVSI AGKDEREFAE AAWASVDAGA 130 140 150 160 170 180 SALELNLSCP HAKGLGLELG MDINAVRKVV EAVATTVNVP VFAKLGLVDK LVDTASAALD 190 200 210 220 230 240 AGASGLVLIN TIRAMVIDID VMEPVLTNKV GGLSGRAIHP IAVRAVYEVY KELKAPIVGV 250 260 270 280 290 300 GGVYEWRDAV ELVLAGASAV QIGSAVADKG LGVFSEVLAG LAWWLHSKGF RSLREAVGAA VR

References

[1]

"A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans." Podar M., Anderson I., Makarova K.S., Elkins J.G., Ivanova N., Wall M.A., Lykidis A., Mavromatis K., Sun H., Hudson M.E., Chen W., Deciu C., Hutchison D., Eads J.R., Anderson A., Fernandes F., Szeto E., Lapidus A. , Kyrpides N.C., Saier M.H. Jr., Richardson P.M., Rachel R., Huber H., Eisen J.A., Koonin E.V., Keller M., Stetter K.O. Genome Biol. 9:R158.1-R158.18(2008) [PubMed: 19000309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000816 Genomic DNA. Translation: ABU81411.1.
RefSeq	YP_001434818.1. NC_009776.1.
3D structure databases
ProteinModelPortal	A8A909.
ModBase	Search...
Protein-protein interaction databases
STRING	A8A909.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5562079.
GenomeReviews	Gene locus Igni_0227 in contig CP000816_GR.
KEGG	iho:Igni_0227.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04551.
HOGENOM	HBG472415.
OMA	VALRMVW.
ProtClustDB	PRK07259.
Family and domain databases
HAMAP	MF_00224. DHO_dh_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005720. Dihydroorotate_DH. IPR024920. Dihydroorotate_DH_1. IPR012135. Dihydroorotate_DH_1_2. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00226.
Pfam	PF01180. DHO_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMs	TIGR01037. PyrD_sub1_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8A909_IGNH4

Accession

Primary (citable) accession number: A8A909

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)