A8A8Z7 (AROE_IGNH4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Igni_0215

Organism

Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]

Taxonomic identifier

453591 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Ignicoccus

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325183
Regions
	Nucleotide binding	122 – 126	5	NADP By similarity
Sites
	Active site	63	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A8A8Z7 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 00D7B50DF1BDC228	FASTA	262	28,672
	10 20 30 40 50 60 MLFAVIGHPI EHSLSPLLHK ISFELMKVEA EYVKVDVPPH RLGDFMSSVD MIFNGINVTI 70 80 90 100 110 120 PHKVEVLKYV DVADDLVNEV GAANTLKIKD GKIYAFNTDV EGVRGSIKDA VDPKGLKVAV 130 140 150 160 170 180 LGAGGAARAA VVALRDEAQV TVFNRTLEKA KRLAEELGVD YAGLNEVDKI KKHDIIINAT 190 200 210 220 230 240 PVGMDGVSMP IPPDVIESRH VLMDMVYRPL YTPFLKVGLA KGAKTVNGLK MLVIQGMESE 250 260 KVWLGASPYW RDVYERLLAS LA

References

[1]

"A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans." Podar M., Anderson I., Makarova K.S., Elkins J.G., Ivanova N., Wall M.A., Lykidis A., Mavromatis K., Sun H., Hudson M.E., Chen W., Deciu C., Hutchison D., Eads J.R., Anderson A., Fernandes F., Szeto E., Lapidus A. , Kyrpides N.C., Saier M.H. Jr., Richardson P.M., Rachel R., Huber H., Eisen J.A., Koonin E.V., Keller M., Stetter K.O. Genome Biol. 9:R158.1-R158.18(2008) [PubMed: 19000309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIN4/I / DSM 18386 / JCM 14125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000816 Genomic DNA. Translation: ABU81399.1.
RefSeq	YP_001434806.1. NC_009776.1.
3D structure databases
ProteinModelPortal	A8A8Z7.
ModBase	Search...
Protein-protein interaction databases
STRING	A8A8Z7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5562108.
GenomeReviews	Gene locus Igni_0215 in contig CP000816_GR.
KEGG	iho:Igni_0215.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05588.
HOGENOM	HBG553408.
OMA	FERWFGI.
Enzyme and pathway databases
BioCyc	IHOS453591:IGNI_0215-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_IGNH4

Accession

Primary (citable) accession number: A8A8Z7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	October 23, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program