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A8A8T2

- SYL_IGNH4

UniProt

A8A8T2 - SYL_IGNH4

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei700 – 7001ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciIHOS453591:GHYN-156-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Igni_0150
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
ProteomesiUP000000262: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10221022Leucine--tRNA ligasePRO_0000334840Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_0150.

Structurei

3D structure databases

ProteinModelPortaliA8A8T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 5711"HIGH" regionAdd
BLAST
Motifi697 – 7015"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A8A8T2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDFVEDFVR YLKEIAAKWR EEWERARLHE ADVDPNRPKF YVTAAFPYPN
60 70 80 90 100
SPMHLGHSRT YSVTDAYARF KRMRGFNVLF PMGFHYTGTP IIAMSEKVKQ
110 120 130 140 150
GLQALRSLGE VKTILEEIWK IKVERNLSIG EAIKEYLRGA GREDLMDKTD
160 170 180 190 200
SIEYLVLFYK VFEIPVEDLE KLTEPLSMAN YFASITEEGM KELGYMIDWR
210 220 230 240 250
RKFTTVDPDF QKFITWQFLK LYDLGYVEKG THPVAWDPVY DTPVSQHDTK
260 270 280 290 300
GDVEPEIEEY DVILFKLKDE DLYLPAATLR AETVFGVTNV WLNPEAEYEV
310 320 330 340 350
VEVDGKRWVL SKKAAYKIKF QKDEVKSLGP IDPKKLLKKM VINPATEEEV
360 370 380 390 400
PVLPARFVDP NVATGVVMSV PAHAPFDYVA LKELEGDPEY SDIVKSIELV
410 420 430 440 450
QVIRVPEEGL LVPQLVEKLG IRDTSDKKKL EEATREVYSK EYRKGRMLES
460 470 480 490 500
VLERVKGDER LRAALKAFLG NDPVPDAREK TAKWLKLFGA GDVFYEIKNA
510 520 530 540 550
PVYSRFGNEV VVKVLKDQWF LNYGDPQWKE LARKALARMR IIPENFLKEF
560 570 580 590 600
EDTIDWLQKR ACARTRGLGT PLPWDKRWII ESLSDSTIYM AFYTVVNILR
610 620 630 640 650
GASVEPEKLQ PEVWDYIMLG KGNPKELEEK YGISAAVLEE ARRSFDYWYP
660 670 680 690 700
VDSRHSGKDL IRNHLTFFIF NHAAIFPEDK WPRQIVVNGF VNLEGKKMSK
710 720 730 740 750
SLGNIIPITV AIRSFAPDII RLVLLHSAEL GSDADFRTEM VSRAISNLRE
760 770 780 790 800
IKSIVEKVKD YNGPRPANLT MLDAWYLSSF VKDVENVTNM MEDLKIREVT
810 820 830 840 850
NVLYFILLNR TKEYLNALEA MGRGLDEVAK WVLRYTVERW VKMMTPFTPF
860 870 880 890 900
FAEEMWHELG FNTFVVTEPW PVKDEELVNP LAEAAKEYVE KVIEDIKEII
910 920 930 940 950
KVAKIEKPKK VRIEVASPEQ VKMLKMAVEF VNSGKSLREF MAEATKVFGK
960 970 980 990 1000
KEAKSLRQAF ERATSLSESM RSVIARGEFD EKAVLEEFKR LIEEEVGSEV
1010 1020
EIRRYEGGKK RPEPLRPAIY VE
Length:1,022
Mass (Da):118,172
Last modified:October 23, 2007 - v1
Checksum:i944517F2056D7283
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000816 Genomic DNA. Translation: ABU81334.1.
RefSeqiWP_011998186.1. NC_009776.1.
YP_001434741.1. NC_009776.1.

Genome annotation databases

EnsemblBacteriaiABU81334; ABU81334; Igni_0150.
GeneIDi5562862.
KEGGiiho:Igni_0150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000816 Genomic DNA. Translation: ABU81334.1 .
RefSeqi WP_011998186.1. NC_009776.1.
YP_001434741.1. NC_009776.1.

3D structure databases

ProteinModelPortali A8A8T2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 453591.Igni_0150.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU81334 ; ABU81334 ; Igni_0150 .
GeneIDi 5562862.
KEGGi iho:Igni_0150.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci IHOS453591:GHYN-156-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIN4/I / DSM 18386 / JCM 14125.

Entry informationi

Entry nameiSYL_IGNH4
AccessioniPrimary (citable) accession number: A8A8T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3