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A8A8T2

- SYL_IGNH4

UniProt

A8A8T2 - SYL_IGNH4

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Protein

Leucine--tRNA ligase

Gene
leuS, Igni_0150
Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei700 – 7001ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciIHOS453591:GHYN-156-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Igni_0150
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
ProteomesiUP000000262: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10221022Leucine--tRNA ligaseUniRule annotationPRO_0000334840Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_0150.

Structurei

3D structure databases

ProteinModelPortaliA8A8T2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 5711"HIGH" regionUniRule annotationAdd
BLAST
Motifi697 – 7015"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A8A8T2-1 [UniParc]FASTAAdd to Basket

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MGDFVEDFVR YLKEIAAKWR EEWERARLHE ADVDPNRPKF YVTAAFPYPN     50
SPMHLGHSRT YSVTDAYARF KRMRGFNVLF PMGFHYTGTP IIAMSEKVKQ 100
GLQALRSLGE VKTILEEIWK IKVERNLSIG EAIKEYLRGA GREDLMDKTD 150
SIEYLVLFYK VFEIPVEDLE KLTEPLSMAN YFASITEEGM KELGYMIDWR 200
RKFTTVDPDF QKFITWQFLK LYDLGYVEKG THPVAWDPVY DTPVSQHDTK 250
GDVEPEIEEY DVILFKLKDE DLYLPAATLR AETVFGVTNV WLNPEAEYEV 300
VEVDGKRWVL SKKAAYKIKF QKDEVKSLGP IDPKKLLKKM VINPATEEEV 350
PVLPARFVDP NVATGVVMSV PAHAPFDYVA LKELEGDPEY SDIVKSIELV 400
QVIRVPEEGL LVPQLVEKLG IRDTSDKKKL EEATREVYSK EYRKGRMLES 450
VLERVKGDER LRAALKAFLG NDPVPDAREK TAKWLKLFGA GDVFYEIKNA 500
PVYSRFGNEV VVKVLKDQWF LNYGDPQWKE LARKALARMR IIPENFLKEF 550
EDTIDWLQKR ACARTRGLGT PLPWDKRWII ESLSDSTIYM AFYTVVNILR 600
GASVEPEKLQ PEVWDYIMLG KGNPKELEEK YGISAAVLEE ARRSFDYWYP 650
VDSRHSGKDL IRNHLTFFIF NHAAIFPEDK WPRQIVVNGF VNLEGKKMSK 700
SLGNIIPITV AIRSFAPDII RLVLLHSAEL GSDADFRTEM VSRAISNLRE 750
IKSIVEKVKD YNGPRPANLT MLDAWYLSSF VKDVENVTNM MEDLKIREVT 800
NVLYFILLNR TKEYLNALEA MGRGLDEVAK WVLRYTVERW VKMMTPFTPF 850
FAEEMWHELG FNTFVVTEPW PVKDEELVNP LAEAAKEYVE KVIEDIKEII 900
KVAKIEKPKK VRIEVASPEQ VKMLKMAVEF VNSGKSLREF MAEATKVFGK 950
KEAKSLRQAF ERATSLSESM RSVIARGEFD EKAVLEEFKR LIEEEVGSEV 1000
EIRRYEGGKK RPEPLRPAIY VE 1022
Length:1,022
Mass (Da):118,172
Last modified:October 23, 2007 - v1
Checksum:i944517F2056D7283
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000816 Genomic DNA. Translation: ABU81334.1.
RefSeqiYP_001434741.1. NC_009776.1.

Genome annotation databases

EnsemblBacteriaiABU81334; ABU81334; Igni_0150.
GeneIDi5562862.
KEGGiiho:Igni_0150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000816 Genomic DNA. Translation: ABU81334.1 .
RefSeqi YP_001434741.1. NC_009776.1.

3D structure databases

ProteinModelPortali A8A8T2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 453591.Igni_0150.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU81334 ; ABU81334 ; Igni_0150 .
GeneIDi 5562862.
KEGGi iho:Igni_0150.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci IHOS453591:GHYN-156-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIN4/I / DSM 18386 / JCM 14125.

Entry informationi

Entry nameiSYL_IGNH4
AccessioniPrimary (citable) accession number: A8A8T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3