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A8A8T2 (SYL_IGNH4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Igni_0150
OrganismIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) [Complete proteome] [HAMAP]
Taxonomic identifier453591 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus

Protein attributes

Sequence length1022 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10221022Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334840

Regions

Motif47 – 5711"HIGH" region HAMAP-Rule MF_00049
Motif697 – 7015"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site7001ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8A8T2 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 944517F2056D7283

FASTA1,022118,172
        10         20         30         40         50         60 
MGDFVEDFVR YLKEIAAKWR EEWERARLHE ADVDPNRPKF YVTAAFPYPN SPMHLGHSRT 

        70         80         90        100        110        120 
YSVTDAYARF KRMRGFNVLF PMGFHYTGTP IIAMSEKVKQ GLQALRSLGE VKTILEEIWK 

       130        140        150        160        170        180 
IKVERNLSIG EAIKEYLRGA GREDLMDKTD SIEYLVLFYK VFEIPVEDLE KLTEPLSMAN 

       190        200        210        220        230        240 
YFASITEEGM KELGYMIDWR RKFTTVDPDF QKFITWQFLK LYDLGYVEKG THPVAWDPVY 

       250        260        270        280        290        300 
DTPVSQHDTK GDVEPEIEEY DVILFKLKDE DLYLPAATLR AETVFGVTNV WLNPEAEYEV 

       310        320        330        340        350        360 
VEVDGKRWVL SKKAAYKIKF QKDEVKSLGP IDPKKLLKKM VINPATEEEV PVLPARFVDP 

       370        380        390        400        410        420 
NVATGVVMSV PAHAPFDYVA LKELEGDPEY SDIVKSIELV QVIRVPEEGL LVPQLVEKLG 

       430        440        450        460        470        480 
IRDTSDKKKL EEATREVYSK EYRKGRMLES VLERVKGDER LRAALKAFLG NDPVPDAREK 

       490        500        510        520        530        540 
TAKWLKLFGA GDVFYEIKNA PVYSRFGNEV VVKVLKDQWF LNYGDPQWKE LARKALARMR 

       550        560        570        580        590        600 
IIPENFLKEF EDTIDWLQKR ACARTRGLGT PLPWDKRWII ESLSDSTIYM AFYTVVNILR 

       610        620        630        640        650        660 
GASVEPEKLQ PEVWDYIMLG KGNPKELEEK YGISAAVLEE ARRSFDYWYP VDSRHSGKDL 

       670        680        690        700        710        720 
IRNHLTFFIF NHAAIFPEDK WPRQIVVNGF VNLEGKKMSK SLGNIIPITV AIRSFAPDII 

       730        740        750        760        770        780 
RLVLLHSAEL GSDADFRTEM VSRAISNLRE IKSIVEKVKD YNGPRPANLT MLDAWYLSSF 

       790        800        810        820        830        840 
VKDVENVTNM MEDLKIREVT NVLYFILLNR TKEYLNALEA MGRGLDEVAK WVLRYTVERW 

       850        860        870        880        890        900 
VKMMTPFTPF FAEEMWHELG FNTFVVTEPW PVKDEELVNP LAEAAKEYVE KVIEDIKEII 

       910        920        930        940        950        960 
KVAKIEKPKK VRIEVASPEQ VKMLKMAVEF VNSGKSLREF MAEATKVFGK KEAKSLRQAF 

       970        980        990       1000       1010       1020 
ERATSLSESM RSVIARGEFD EKAVLEEFKR LIEEEVGSEV EIRRYEGGKK RPEPLRPAIY 


VE 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000816 Genomic DNA. Translation: ABU81334.1.
RefSeqYP_001434741.1. NC_009776.1.

3D structure databases

ProteinModelPortalA8A8T2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING453591.Igni_0150.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU81334; ABU81334; Igni_0150.
GeneID5562862.
KEGGiho:Igni_0150.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000216620.
KOK01869.
OMAIDKWLLH.

Enzyme and pathway databases

BioCycIHOS453591:GHYN-156-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_A. Leu_tRNA_synth_A.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00395. leuS_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_IGNH4
AccessionPrimary (citable) accession number: A8A8T2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries