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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei700ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciIHOS453591:G1G9W-156-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Igni_0150
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
Proteomesi
  • UP000000262 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003348401 – 1022Leucine--tRNA ligaseAdd BLAST1022

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_0150

Structurei

3D structure databases

ProteinModelPortaliA8A8T2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi47 – 57"HIGH" regionAdd BLAST11
Motifi697 – 701"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit

Sequencei

Sequence statusi: Complete.

A8A8T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDFVEDFVR YLKEIAAKWR EEWERARLHE ADVDPNRPKF YVTAAFPYPN
60 70 80 90 100
SPMHLGHSRT YSVTDAYARF KRMRGFNVLF PMGFHYTGTP IIAMSEKVKQ
110 120 130 140 150
GLQALRSLGE VKTILEEIWK IKVERNLSIG EAIKEYLRGA GREDLMDKTD
160 170 180 190 200
SIEYLVLFYK VFEIPVEDLE KLTEPLSMAN YFASITEEGM KELGYMIDWR
210 220 230 240 250
RKFTTVDPDF QKFITWQFLK LYDLGYVEKG THPVAWDPVY DTPVSQHDTK
260 270 280 290 300
GDVEPEIEEY DVILFKLKDE DLYLPAATLR AETVFGVTNV WLNPEAEYEV
310 320 330 340 350
VEVDGKRWVL SKKAAYKIKF QKDEVKSLGP IDPKKLLKKM VINPATEEEV
360 370 380 390 400
PVLPARFVDP NVATGVVMSV PAHAPFDYVA LKELEGDPEY SDIVKSIELV
410 420 430 440 450
QVIRVPEEGL LVPQLVEKLG IRDTSDKKKL EEATREVYSK EYRKGRMLES
460 470 480 490 500
VLERVKGDER LRAALKAFLG NDPVPDAREK TAKWLKLFGA GDVFYEIKNA
510 520 530 540 550
PVYSRFGNEV VVKVLKDQWF LNYGDPQWKE LARKALARMR IIPENFLKEF
560 570 580 590 600
EDTIDWLQKR ACARTRGLGT PLPWDKRWII ESLSDSTIYM AFYTVVNILR
610 620 630 640 650
GASVEPEKLQ PEVWDYIMLG KGNPKELEEK YGISAAVLEE ARRSFDYWYP
660 670 680 690 700
VDSRHSGKDL IRNHLTFFIF NHAAIFPEDK WPRQIVVNGF VNLEGKKMSK
710 720 730 740 750
SLGNIIPITV AIRSFAPDII RLVLLHSAEL GSDADFRTEM VSRAISNLRE
760 770 780 790 800
IKSIVEKVKD YNGPRPANLT MLDAWYLSSF VKDVENVTNM MEDLKIREVT
810 820 830 840 850
NVLYFILLNR TKEYLNALEA MGRGLDEVAK WVLRYTVERW VKMMTPFTPF
860 870 880 890 900
FAEEMWHELG FNTFVVTEPW PVKDEELVNP LAEAAKEYVE KVIEDIKEII
910 920 930 940 950
KVAKIEKPKK VRIEVASPEQ VKMLKMAVEF VNSGKSLREF MAEATKVFGK
960 970 980 990 1000
KEAKSLRQAF ERATSLSESM RSVIARGEFD EKAVLEEFKR LIEEEVGSEV
1010 1020
EIRRYEGGKK RPEPLRPAIY VE
Length:1,022
Mass (Da):118,172
Last modified:October 23, 2007 - v1
Checksum:i944517F2056D7283
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA Translation: ABU81334.1
RefSeqiWP_011998186.1, NC_009776.1

Genome annotation databases

EnsemblBacteriaiABU81334; ABU81334; Igni_0150
GeneIDi5562862
KEGGiiho:Igni_0150

Entry informationi

Entry nameiSYL_IGNH4
AccessioniPrimary (citable) accession number: A8A8T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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