A8A6G7 (YIDC_ECOHS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane protein insertase YidC

Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC

Gene names

Name:	yidC
Ordered Locus Names:	EcHS_A3919

Organism

Escherichia coli O9:H4 (strain HS) [Complete proteome] [HAMAP]

Taxonomic identifier

331112 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins By similarity. HAMAP-Rule MF_01810
Subunit structure	Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01810.
Sequence similarities	Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein insertion into membrane Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 548	548	Membrane protein insertase YidC HAMAP-Rule MF_01810		PRO_1000070086
Regions
	Transmembrane	6 – 26	21	Helical; Potential
	Transmembrane	350 – 370	21	Helical; Potential
	Transmembrane	420 – 440	21	Helical; Potential
	Transmembrane	458 – 478	21	Helical; Potential
	Transmembrane	499 – 519	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A8A6G7 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 8A634F07699F0D94	FASTA	548	61,540
	10 20 30 40 50 60 MDSQRNLLVI ALLFVSFMIW QAWEQDKNPQ PQAQQTTQTT TTAAGSAADQ GVPASGQGKL 70 80 90 100 110 120 ISVKTDVLDL TINTRGGDVE QALLPAYPKE LNSTQPFQLL ETSPQFIYQA QSGLTGRDGP 130 140 150 160 170 180 DNPANGPRPL YNVEKDAYVL AEGQNELQVP MTYTDAAGNT FTKTFVLKRG DYAVNVNYNV 190 200 210 220 230 240 QNAGEKPLEI STFGQLKQSI TLPPHLDTGS SNFALHTFRG AAYSTPDEKY EKYKFDTIAD 250 260 270 280 290 300 NENLNISSKG GWVAMLQQYF ATAWIPHNDG TNNFYTANLG NGIAAIGYKS QPVLVQPGQT 310 320 330 340 350 360 GAMNSTLWVG PEIQDKMAAV APHLDLTVDY GWLWFISQPL FKLLKWIHSF VGNWGFSIII 370 380 390 400 410 420 ITFIVRGIMY PLTKAQYTSM AKMRMLQPKI QAMRERLGDD KQRISQEMMA LYKAEKVNPL 430 440 450 460 470 480 GGCFPLLIQM PIFLALYYML MGSVELRQAP FALWIHDLSA QDPYYILPIL MGVTMFFIQK 490 500 510 520 530 540 MSPTTVTDPM QQKIMTFMPV IFTVFFLWFP SGLVLYYIVS NLVTIIQQQL IYRGLEKRGL HSREKKKS

References

[1]

"The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates." Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J. J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000802 Genomic DNA. Translation: ABV08121.1.
RefSeq	YP_001460504.1. NC_009800.1.
3D structure databases
ProteinModelPortal	A8A6G7.
SMR	A8A6G7. Positions 59-329.
ModBase	Search...
Protein-protein interaction databases
IntAct	A8A6G7. 32 interactions.
STRING	331112.EcHS_A3919.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV08121; ABV08121; EcHS_A3919.
GeneID	5592653.
KEGG	ecx:EcHS_A3919.
PATRIC	18317808. VBIEscCol77814_3829.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0706.
HOGENOM	HOG000101822.
KO	K03217.
OMA	HTTVFTA.
ProtClustDB	PRK01318.
Enzyme and pathway databases
BioCyc	ECOL331112:GHHI-3912-MONOMER.
Family and domain databases
HAMAP	MF_01810. YidC_type1.
InterPro	IPR019998. Membr_insert_YidC. IPR001708. Membrane_insert_OXA1/ALB3/YidC. [Graphical view]
PANTHER	PTHR12428. PTHR12428. 1 hit.
Pfam	PF02096. 60KD_IMP. 1 hit. [Graphical view]
PRINTS	PR00701. 60KDINNERMP. PR01900. YIDCPROTEIN.
TIGRFAMs	TIGR03593. yidC_nterm. 1 hit. TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YIDC_ECOHS

Accession

Primary (citable) accession number: A8A6G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 23, 2007
Last modified:	May 29, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program