Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A8A4Q0 (UXAC_ECOHS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uronate isomerase

EC=5.3.1.12
Alternative name(s):
Glucuronate isomerase
Uronic isomerase
Gene names
Name:uxaC
Ordered Locus Names:EcHS_A3275
OrganismEscherichia coli O9:H4 (strain HS) [Complete proteome] [HAMAP]
Taxonomic identifier331112 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucuronate = D-fructuronate. HAMAP-Rule MF_00675

D-galacturonate = D-tagaturonate. HAMAP-Rule MF_00675

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00675

Sequence similarities

Belongs to the uronate isomerase family.

Ontologies

Keywords
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglucuronate catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglucuronate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Uronate isomerase HAMAP-Rule MF_00675
PRO_1000061951

Sequences

Sequence LengthMass (Da)Tools
A8A4Q0 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 9E51AA7B88411281

FASTA47053,987
        10         20         30         40         50         60 
MTPFMTEDFL LDTEFARRLY HDYAKDQPIF DYHCHLPPQQ IAEDYRFKNL YDIWLKGDHY 

        70         80         90        100        110        120 
KWRAMRTNGV AERLCTGDAS DREKFDAWAA TVPHTIGNPL YHWTHLELRR PFGITGKLLS 

       130        140        150        160        170        180 
PSTADEIWNE CNELLAQDNF SARGIMQQMN VKMVGTTDDP IDSLEHHAEI AKDGSFTIKV 

       190        200        210        220        230        240 
LPSWRPDKAF NIEQATFNDY MAKLGEVSDT DIRRFADLQT ALTKRLDHFA AHGCKVSDHA 

       250        260        270        280        290        300 
LDVVMFAEAN EAELDSILAR RLAGETLSEH EVAQFKTAVL VFLGAEYARR GWVQQYHIGA 

       310        320        330        340        350        360 
LRNNNLRQFK LLGPDVGFDS INDRPMAEEL SKLLSKQNEE NLLPKTILYC LNPRDNEVLG 

       370        380        390        400        410        420 
TMIGNFQGEG MPGKMQFGSG WWFNDQKDGM ERQMTQLAQL GLLSRFVGML TDSRSFLSYT 

       430        440        450        460        470 
RHEYFRRILC QMIGRWVEAG EAPADINLLG EMVKNICFNN ARDYFAIELN 

« Hide

References

[1]"The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000802 Genomic DNA. Translation: ABV07504.1.
RefSeqYP_001459887.1. NC_009800.1.

3D structure databases

ProteinModelPortalA8A4Q0.
SMRA8A4Q0. Positions 4-468.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING331112.EcHS_A3275.

Proteomic databases

PRIDEA8A4Q0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV07504; ABV07504; EcHS_A3275.
GeneID5592293.
KEGGecx:EcHS_A3275.
PATRIC18316523. VBIEscCol77814_3199.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1904.
HOGENOMHOG000224075.
KOK01812.
OMAGHTDPRW.
OrthoDBEOG6J1D95.
ProtClustDBPRK02925.

Enzyme and pathway databases

BioCycECOL331112:GHHI-3268-MONOMER.
UniPathwayUPA00246.

Family and domain databases

Gene3D1.10.2020.10. 1 hit.
HAMAPMF_00675. UxaC.
InterProIPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamPF02614. UxaC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUXAC_ECOHS
AccessionPrimary (citable) accession number: A8A4Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways