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Protein

Uronate isomerase

Gene

uxaC

Organism
Escherichia coli O9:H4 (strain HS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucuronate = D-fructuronate.UniRule annotation
D-galacturonate = D-tagaturonate.UniRule annotation

Pathway:ipentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciECOL331112:GHHI-3268-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Uronate isomeraseUniRule annotation (EC:5.3.1.12UniRule annotation)
Alternative name(s):
Glucuronate isomeraseUniRule annotation
Uronic isomeraseUniRule annotation
Gene namesi
Name:uxaCUniRule annotation
Ordered Locus Names:EcHS_A3275
OrganismiEscherichia coli O9:H4 (strain HS)
Taxonomic identifieri331112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Uronate isomerasePRO_1000061951Add
BLAST

Proteomic databases

PRIDEiA8A4Q0.

Structurei

3D structure databases

ProteinModelPortaliA8A4Q0.
SMRiA8A4Q0. Positions 4-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uronate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1904.
HOGENOMiHOG000224075.
OMAiGHTDPRW.
OrthoDBiEOG6J1D95.

Family and domain databases

Gene3Di1.10.2020.10. 1 hit.
HAMAPiMF_00675. UxaC.
InterProiIPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamiPF02614. UxaC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8A4Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPFMTEDFL LDTEFARRLY HDYAKDQPIF DYHCHLPPQQ IAEDYRFKNL
60 70 80 90 100
YDIWLKGDHY KWRAMRTNGV AERLCTGDAS DREKFDAWAA TVPHTIGNPL
110 120 130 140 150
YHWTHLELRR PFGITGKLLS PSTADEIWNE CNELLAQDNF SARGIMQQMN
160 170 180 190 200
VKMVGTTDDP IDSLEHHAEI AKDGSFTIKV LPSWRPDKAF NIEQATFNDY
210 220 230 240 250
MAKLGEVSDT DIRRFADLQT ALTKRLDHFA AHGCKVSDHA LDVVMFAEAN
260 270 280 290 300
EAELDSILAR RLAGETLSEH EVAQFKTAVL VFLGAEYARR GWVQQYHIGA
310 320 330 340 350
LRNNNLRQFK LLGPDVGFDS INDRPMAEEL SKLLSKQNEE NLLPKTILYC
360 370 380 390 400
LNPRDNEVLG TMIGNFQGEG MPGKMQFGSG WWFNDQKDGM ERQMTQLAQL
410 420 430 440 450
GLLSRFVGML TDSRSFLSYT RHEYFRRILC QMIGRWVEAG EAPADINLLG
460 470
EMVKNICFNN ARDYFAIELN
Length:470
Mass (Da):53,987
Last modified:October 23, 2007 - v1
Checksum:i9E51AA7B88411281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA. Translation: ABV07504.1.

Genome annotation databases

EnsemblBacteriaiABV07504; ABV07504; EcHS_A3275.
PATRICi18316523. VBIEscCol77814_3199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA. Translation: ABV07504.1.

3D structure databases

ProteinModelPortaliA8A4Q0.
SMRiA8A4Q0. Positions 4-468.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA8A4Q0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV07504; ABV07504; EcHS_A3275.
PATRICi18316523. VBIEscCol77814_3199.

Phylogenomic databases

eggNOGiCOG1904.
HOGENOMiHOG000224075.
OMAiGHTDPRW.
OrthoDBiEOG6J1D95.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciECOL331112:GHHI-3268-MONOMER.

Family and domain databases

Gene3Di1.10.2020.10. 1 hit.
HAMAPiMF_00675. UxaC.
InterProiIPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamiPF02614. UxaC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HS.

Entry informationi

Entry nameiUXAC_ECOHS
AccessioniPrimary (citable) accession number: A8A4Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: July 22, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.