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A8A2M8

- FCTA_ECOHS

UniProt

A8A2M8 - FCTA_ECOHS

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Protein
Formyl-coenzyme A transferase
Gene
frc, EcHS_A2511
Organism
Escherichia coli O9:H4 (strain HS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate By similarity.UniRule annotation

Catalytic activityi

Formyl-CoA + oxalate = formate + oxalyl-CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961Coenzyme A By similarity
Active sitei169 – 1691Nucleophile By similarity

GO - Molecular functioni

  1. formyl-CoA transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. oxalate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciECOL331112:GHHI-2497-MONOMER.
UniPathwayiUPA00540; UER00598.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl-coenzyme A transferase (EC:2.8.3.16)
Short name:
Formyl-CoA transferase
Gene namesi
Name:frc
Ordered Locus Names:EcHS_A2511
OrganismiEscherichia coli O9:H4 (strain HS)
Taxonomic identifieri331112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001123: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Formyl-coenzyme A transferaseUniRule annotation
PRO_1000062169Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi331112.EcHS_A2511.

Structurei

3D structure databases

ProteinModelPortaliA8A2M8.
SMRiA8A2M8. Positions 2-416.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1804.
HOGENOMiHOG000219745.
KOiK07749.
OMAiFATIEDW.
OrthoDBiEOG6C8MWH.

Family and domain databases

Gene3Di3.40.50.10540. 2 hits.
HAMAPiMF_00742. Formyl_CoA_transfer.
InterProiIPR003673. CoA-Trfase_fam_III.
IPR023606. CoA-Trfase_III_dom.
IPR017659. Formyl-CoA_transferase.
[Graphical view]
PANTHERiPTHR11837. PTHR11837. 1 hit.
PfamiPF02515. CoA_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF89796. SSF89796. 1 hit.
TIGRFAMsiTIGR03253. oxalate_frc. 1 hit.

Sequencei

Sequence statusi: Complete.

A8A2M8-1 [UniParc]FASTAAdd to Basket

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MSTPLQGIKV LDFTGVQSGP SCTQMLAWFG ADVIKIERPG VGDVTRHQLR    50
DIPDIDALYF TMLNSNKRSI ELNTKTAEGK EVMEKLIREA DILVENFHPG 100
AIDHMGFTWE HIQEINPRLI FGSIKGFDEC SPYVNVKAYE NVAQAAGGAA 150
STTGFWDGPP LVSAAALGDS NTGMHLLIGL LAALLHREKT GRGQRVTMSM 200
QDAVLNLCRV KLRDQQRLDK LGYLEEYPQY PNGTFGDAVP RGGNAGGGGQ 250
PGWILKCKGW ETDPNAYIYF TIQEQNWENT CKAIGKPEWI TDPAYSTAHA 300
RQPHIFDIFA EIEKYTVTID KHEAVAYLTQ FDIPCAPVLS MKEISLDPSL 350
RQSGSVVEVE QPLRGKYLTV GCPMKFSAFT PDIKAAPLLG EHTAAVLQEL 400
GYSDDEIAAM KQNHAI 416
Length:416
Mass (Da):45,828
Last modified:October 23, 2007 - v1
Checksum:i97F7FA4001073301
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000802 Genomic DNA. Translation: ABV06782.1.
RefSeqiYP_001459165.1. NC_009800.1.

Genome annotation databases

EnsemblBacteriaiABV06782; ABV06782; EcHS_A2511.
GeneIDi5592503.
KEGGiecx:EcHS_A2511.
PATRICi18315000. VBIEscCol77814_2461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000802 Genomic DNA. Translation: ABV06782.1 .
RefSeqi YP_001459165.1. NC_009800.1.

3D structure databases

ProteinModelPortali A8A2M8.
SMRi A8A2M8. Positions 2-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331112.EcHS_A2511.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV06782 ; ABV06782 ; EcHS_A2511 .
GeneIDi 5592503.
KEGGi ecx:EcHS_A2511.
PATRICi 18315000. VBIEscCol77814_2461.

Phylogenomic databases

eggNOGi COG1804.
HOGENOMi HOG000219745.
KOi K07749.
OMAi FATIEDW.
OrthoDBi EOG6C8MWH.

Enzyme and pathway databases

UniPathwayi UPA00540 ; UER00598 .
BioCyci ECOL331112:GHHI-2497-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10540. 2 hits.
HAMAPi MF_00742. Formyl_CoA_transfer.
InterProi IPR003673. CoA-Trfase_fam_III.
IPR023606. CoA-Trfase_III_dom.
IPR017659. Formyl-CoA_transferase.
[Graphical view ]
PANTHERi PTHR11837. PTHR11837. 1 hit.
Pfami PF02515. CoA_transf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF89796. SSF89796. 1 hit.
TIGRFAMsi TIGR03253. oxalate_frc. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HS.

Entry informationi

Entry nameiFCTA_ECOHS
AccessioniPrimary (citable) accession number: A8A2M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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