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Protein

Nucleoside triphosphatase NudI

Gene

nudI

Organism
Escherichia coli O9:H4 (strain HS)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation
dUTP + H2O = dUMP + diphosphate.UniRule annotation
dTTP + H2O = dTMP + diphosphate.UniRule annotation
dCTP + H2O = dCMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciECOL331112:GHHI-2382-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside triphosphatase NudIUniRule annotation (EC:3.6.1.19UniRule annotation)
Alternative name(s):
Pyrimidine deoxynucleoside triphosphate diphosphataseUniRule annotation
dCTP diphosphataseUniRule annotation (EC:3.6.1.12UniRule annotation)
dTTP diphosphataseUniRule annotation (EC:3.6.1.-UniRule annotation)
dUTP diphosphataseUniRule annotation (EC:3.6.1.23UniRule annotation)
Gene namesi
Name:nudIUniRule annotation
Ordered Locus Names:EcHS_A2396
OrganismiEscherichia coli O9:H4 (strain HS)
Taxonomic identifieri331112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Nucleoside triphosphatase NudIPRO_0000342133Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA8A2B8.
SMRiA8A2B8. Positions 4-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 141141Nudix hydrolaseUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 5922Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. NudI subfamily.UniRule annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000059287.
KOiK12944.
OMAiNEEFDDY.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_01846. Nudix_NudI. 1 hit.
InterProiIPR023781. Nucleoside_triphosphatase_NudI.
IPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8A2B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQRTIVCPL IQNDGAYLLC KMADDRGVFP GQWALSGGGV EPGERIEEAL
60 70 80 90 100
RREIREELGE QLLLTEITPW TFSDDIRTKT YADGRKEEIY MIYLIFDCVS
110 120 130 140
ANREVKINEE FQDYAWVKPE DLVHYDLNVA TRKTLRLKGL L
Length:141
Mass (Da):16,371
Last modified:October 23, 2007 - v1
Checksum:i71BF110D627B42EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA. Translation: ABV06672.1.
RefSeqiWP_001249884.1. NC_009800.1.

Genome annotation databases

EnsemblBacteriaiABV06672; ABV06672; EcHS_A2396.
KEGGiecx:EcHS_A2396.
PATRICi18314770. VBIEscCol77814_2347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA. Translation: ABV06672.1.
RefSeqiWP_001249884.1. NC_009800.1.

3D structure databases

ProteinModelPortaliA8A2B8.
SMRiA8A2B8. Positions 4-137.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV06672; ABV06672; EcHS_A2396.
KEGGiecx:EcHS_A2396.
PATRICi18314770. VBIEscCol77814_2347.

Phylogenomic databases

HOGENOMiHOG000059287.
KOiK12944.
OMAiNEEFDDY.

Enzyme and pathway databases

BioCyciECOL331112:GHHI-2382-MONOMER.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_01846. Nudix_NudI. 1 hit.
InterProiIPR023781. Nucleoside_triphosphatase_NudI.
IPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUDI_ECOHS
AccessioniPrimary (citable) accession number: A8A2B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 23, 2007
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.