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Protein

Nucleoside triphosphatase NudI

Gene

nudI

Organism
Escherichia coli O9:H4 (strain HS)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation
dUTP + H2O = dUMP + diphosphate.UniRule annotation
dTTP + H2O = dTMP + diphosphate.UniRule annotation
dCTP + H2O = dCMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciECOL331112:GHHI-2382-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside triphosphatase NudIUniRule annotation (EC:3.6.1.19UniRule annotation)
Alternative name(s):
Pyrimidine deoxynucleoside triphosphate diphosphataseUniRule annotation
dCTP diphosphataseUniRule annotation (EC:3.6.1.12UniRule annotation)
dTTP diphosphataseUniRule annotation (EC:3.6.1.-UniRule annotation)
dUTP diphosphataseUniRule annotation (EC:3.6.1.23UniRule annotation)
Gene namesi
Name:nudIUniRule annotation
Ordered Locus Names:EcHS_A2396
OrganismiEscherichia coli O9:H4 (strain HS)
Taxonomic identifieri331112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Nucleoside triphosphatase NudIPRO_0000342133Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA8A2B8.
SMRiA8A2B8. Positions 4-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 141141Nudix hydrolaseUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 5922Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. NudI subfamily.UniRule annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000059287.
KOiK12944.
OMAiNEEFDDY.
OrthoDBiEOG6GN73N.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_01846. Nudix_NudI.
InterProiIPR023781. Nucleoside_triphosphatase_NudI.
IPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8A2B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQRTIVCPL IQNDGAYLLC KMADDRGVFP GQWALSGGGV EPGERIEEAL
60 70 80 90 100
RREIREELGE QLLLTEITPW TFSDDIRTKT YADGRKEEIY MIYLIFDCVS
110 120 130 140
ANREVKINEE FQDYAWVKPE DLVHYDLNVA TRKTLRLKGL L
Length:141
Mass (Da):16,371
Last modified:October 23, 2007 - v1
Checksum:i71BF110D627B42EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA. Translation: ABV06672.1.
RefSeqiWP_001249884.1. NC_009800.1.

Genome annotation databases

EnsemblBacteriaiABV06672; ABV06672; EcHS_A2396.
KEGGiecx:EcHS_A2396.
PATRICi18314770. VBIEscCol77814_2347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA. Translation: ABV06672.1.
RefSeqiWP_001249884.1. NC_009800.1.

3D structure databases

ProteinModelPortaliA8A2B8.
SMRiA8A2B8. Positions 4-137.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV06672; ABV06672; EcHS_A2396.
KEGGiecx:EcHS_A2396.
PATRICi18314770. VBIEscCol77814_2347.

Phylogenomic databases

HOGENOMiHOG000059287.
KOiK12944.
OMAiNEEFDDY.
OrthoDBiEOG6GN73N.

Enzyme and pathway databases

BioCyciECOL331112:GHHI-2382-MONOMER.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_01846. Nudix_NudI.
InterProiIPR023781. Nucleoside_triphosphatase_NudI.
IPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HS.

Entry informationi

Entry nameiNUDI_ECOHS
AccessioniPrimary (citable) accession number: A8A2B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 23, 2007
Last modified: November 11, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.