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A8A0L0

- MDTK_ECOHS

UniProt

A8A0L0 - MDTK_ECOHS

Protein

Multidrug resistance protein MdtK

Gene

mdtK

Organism
Escherichia coli O9:H4 (strain HS)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Multidrug efflux pump that functions probably as a Na+/drug antiporter.UniRule annotation

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-HAMAP
    2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    BioCyciECOL331112:GHHI-1733-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance protein MdtKUniRule annotation
    Alternative name(s):
    Multidrug-efflux transporterUniRule annotation
    Gene namesi
    Name:mdtKUniRule annotation
    Ordered Locus Names:EcHS_A1743
    OrganismiEscherichia coli O9:H4 (strain HS)
    Taxonomic identifieri331112 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001123: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Multidrug resistance protein MdtKPRO_1000060796Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331112.EcHS_A1743.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalUniRule annotationAdd
    BLAST
    Transmembranei53 – 7321HelicalUniRule annotationAdd
    BLAST
    Transmembranei93 – 11321HelicalUniRule annotationAdd
    BLAST
    Transmembranei127 – 14721HelicalUniRule annotationAdd
    BLAST
    Transmembranei160 – 18021HelicalUniRule annotationAdd
    BLAST
    Transmembranei189 – 20921HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei276 – 29621HelicalUniRule annotationAdd
    BLAST
    Transmembranei314 – 33421HelicalUniRule annotationAdd
    BLAST
    Transmembranei350 – 37021HelicalUniRule annotationAdd
    BLAST
    Transmembranei387 – 40721HelicalUniRule annotationAdd
    BLAST
    Transmembranei418 – 43821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOGENOMiHOG000038538.
    KOiK03327.
    OMAiGGVGCGW.
    OrthoDBiEOG6423C5.

    Family and domain databases

    HAMAPiMF_00400. MdtK.
    InterProiIPR002528. MATE.
    IPR022913. Multidrug-R_MdtK.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8A0L0-1 [UniParc]FASTAAdd to Basket

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    MQKYISEARL LLALAIPVIL AQIAQTAMGF VDTVMAGGYS ATDMAAVAIG    50
    TSIWLPAILF GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSV 100
    LIMLVLWNAG YIIRSMENID PALAEKAVGY LRALLWGAPG YLFFQVARNQ 150
    CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY GHFGMPELGG VGCGVATAAV 200
    YWVMFLAMVS YIKRARSMRD IRNEKGTAKP DPAVMKRLIQ LGLPIALALF 250
    FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG 300
    YRLGQGSTLD AQTAARTGLM VGVCMATLTA IFTVSLREQI ALLYNDNPEV 350
    VTLAAHLMLL AAVYQISDSI QVIGSGILRG YKDTRSIFYI TFTAYWVLGL 400
    PSGYILALTD LVVEPMGPAG FWIGFIIGLT SAAIMMMLRM RFLQRMPSAI 450
    ILQRASR 457
    Length:457
    Mass (Da):49,479
    Last modified:October 23, 2007 - v1
    Checksum:i43777F14A029EAC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000802 Genomic DNA. Translation: ABV06064.1.
    RefSeqiYP_001458447.1. NC_009800.1.

    Genome annotation databases

    EnsemblBacteriaiABV06064; ABV06064; EcHS_A1743.
    GeneIDi5591252.
    KEGGiecx:EcHS_A1743.
    PATRICi18313470. VBIEscCol77814_1708.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000802 Genomic DNA. Translation: ABV06064.1 .
    RefSeqi YP_001458447.1. NC_009800.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331112.EcHS_A1743.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV06064 ; ABV06064 ; EcHS_A1743 .
    GeneIDi 5591252.
    KEGGi ecx:EcHS_A1743.
    PATRICi 18313470. VBIEscCol77814_1708.

    Phylogenomic databases

    eggNOGi COG0534.
    HOGENOMi HOG000038538.
    KOi K03327.
    OMAi GGVGCGW.
    OrthoDBi EOG6423C5.

    Enzyme and pathway databases

    BioCyci ECOL331112:GHHI-1733-MONOMER.

    Family and domain databases

    HAMAPi MF_00400. MdtK.
    InterProi IPR002528. MATE.
    IPR022913. Multidrug-R_MdtK.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
      Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
      J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HS.

    Entry informationi

    Entry nameiMDTK_ECOHS
    AccessioniPrimary (citable) accession number: A8A0L0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3