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Protein

Multidrug resistance protein MdtK

Gene

mdtK

Organism
Escherichia coli O9:H4 (strain HS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Multidrug efflux pump that functions probably as a Na+/drug antiporter.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciECOL331112:GHHI-1733-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtKUniRule annotation
Alternative name(s):
Multidrug-efflux transporterUniRule annotation
Gene namesi
Name:mdtKUniRule annotation
Ordered Locus Names:EcHS_A1743
OrganismiEscherichia coli O9:H4 (strain HS)
Taxonomic identifieri331112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001123 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Transmembranei53 – 7321HelicalUniRule annotationAdd
BLAST
Transmembranei93 – 11321HelicalUniRule annotationAdd
BLAST
Transmembranei127 – 14721HelicalUniRule annotationAdd
BLAST
Transmembranei160 – 18021HelicalUniRule annotationAdd
BLAST
Transmembranei189 – 20921HelicalUniRule annotationAdd
BLAST
Transmembranei243 – 26321HelicalUniRule annotationAdd
BLAST
Transmembranei276 – 29621HelicalUniRule annotationAdd
BLAST
Transmembranei314 – 33421HelicalUniRule annotationAdd
BLAST
Transmembranei350 – 37021HelicalUniRule annotationAdd
BLAST
Transmembranei387 – 40721HelicalUniRule annotationAdd
BLAST
Transmembranei418 – 43821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Multidrug resistance protein MdtKPRO_1000060796Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331112.EcHS_A1743.

Family & Domainsi

Sequence similaritiesi

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiSIVFMLP.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
PIRSFiPIRSF006603. DinF. 1 hit.
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A8A0L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKYISEARL LLALAIPVIL AQIAQTAMGF VDTVMAGGYS ATDMAAVAIG
60 70 80 90 100
TSIWLPAILF GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSV
110 120 130 140 150
LIMLVLWNAG YIIRSMENID PALAEKAVGY LRALLWGAPG YLFFQVARNQ
160 170 180 190 200
CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY GHFGMPELGG VGCGVATAAV
210 220 230 240 250
YWVMFLAMVS YIKRARSMRD IRNEKGTAKP DPAVMKRLIQ LGLPIALALF
260 270 280 290 300
FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG
310 320 330 340 350
YRLGQGSTLD AQTAARTGLM VGVCMATLTA IFTVSLREQI ALLYNDNPEV
360 370 380 390 400
VTLAAHLMLL AAVYQISDSI QVIGSGILRG YKDTRSIFYI TFTAYWVLGL
410 420 430 440 450
PSGYILALTD LVVEPMGPAG FWIGFIIGLT SAAIMMMLRM RFLQRMPSAI

ILQRASR
Length:457
Mass (Da):49,479
Last modified:October 23, 2007 - v1
Checksum:i43777F14A029EAC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA. Translation: ABV06064.1.
RefSeqiWP_001174962.1. NC_009800.1.

Genome annotation databases

EnsemblBacteriaiABV06064; ABV06064; EcHS_A1743.
KEGGiecx:EcHS_A1743.
PATRICi18313470. VBIEscCol77814_1708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA. Translation: ABV06064.1.
RefSeqiWP_001174962.1. NC_009800.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi331112.EcHS_A1743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV06064; ABV06064; EcHS_A1743.
KEGGiecx:EcHS_A1743.
PATRICi18313470. VBIEscCol77814_1708.

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiSIVFMLP.
OrthoDBiEOG6423C5.

Enzyme and pathway databases

BioCyciECOL331112:GHHI-1733-MONOMER.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
PIRSFiPIRSF006603. DinF. 1 hit.
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HS.

Entry informationi

Entry nameiMDTK_ECOHS
AccessioniPrimary (citable) accession number: A8A0L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 27, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.