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Protein

Multidrug resistance protein MdtG

Gene

mdtG

Organism
Escherichia coli O9:H4 (strain HS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Confers resistance to fosfomycin and deoxycholate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Enzyme and pathway databases

BioCyciECOL331112:GHHI-1167-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtGUniRule annotation
Gene namesi
Name:mdtGUniRule annotation
Ordered Locus Names:EcHS_A1175
OrganismiEscherichia coli O9:H4 (strain HS)
Taxonomic identifieri331112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalUniRule annotationAdd
BLAST
Transmembranei58 – 7821HelicalUniRule annotationAdd
BLAST
Transmembranei92 – 11221HelicalUniRule annotationAdd
BLAST
Transmembranei115 – 13521HelicalUniRule annotationAdd
BLAST
Transmembranei146 – 16621HelicalUniRule annotationAdd
BLAST
Transmembranei173 – 19321HelicalUniRule annotationAdd
BLAST
Transmembranei224 – 24421HelicalUniRule annotationAdd
BLAST
Transmembranei256 – 27621HelicalUniRule annotationAdd
BLAST
Transmembranei291 – 31121HelicalUniRule annotationAdd
BLAST
Transmembranei379 – 39921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Multidrug resistance protein MdtGPRO_0000316874Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA7ZZ10.
SMRiA7ZZ10. Positions 144-173, 278-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066093.
KOiK08161.
OMAiFITTMII.
OrthoDBiEOG6VF34T.

Family and domain databases

HAMAPiMF_01528. MFS_MdtG.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZZ10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPCENDTPI NWKRNLIVAW LGCFLTGAAF SLVMPFLPLY VEQLGVTGHS
60 70 80 90 100
ALNMWSGIVF SITFLFSAIA SPFWGGLADR KGRKLMLLRS ALGMGIVMVL
110 120 130 140 150
MGLAQNIWQF LILRALLGLL GGFVPNANAL IATQVPRNKS GWALGTLSTG
160 170 180 190 200
GVSGALLGPM AGGLLADSYG LRPVFFITAS VLILCFFVTL FCIREKFQPV
210 220 230 240 250
SKKEMLHMRE VVTSLKNPKL VLSLFVTTLI IQVATGSIAP ILTLYVRELA
260 270 280 290 300
GNVSNVAFIS GMIASVPGVA ALLLSAPRLG KLGDRIGPEK ILITALIFSV
310 320 330 340 350
LLLIPMSYVQ TPLQLGILRF LLGAADGALL PAVQTLLVYN SSNQIAGRIF
360 370 380 390 400
SYNQSFRDIG NVTGPLMGAA ISANYGFRAV FLVTAGVVLF NAVYSWNSLR

RRRIPQVSN
Length:409
Mass (Da):43,980
Last modified:October 23, 2007 - v1
Checksum:iB322579033237AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA. Translation: ABV05514.1.
RefSeqiWP_000074166.1. NC_009800.1.

Genome annotation databases

EnsemblBacteriaiABV05514; ABV05514; EcHS_A1175.
KEGGiecx:EcHS_A1175.
PATRICi18312330. VBIEscCol77814_1140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA. Translation: ABV05514.1.
RefSeqiWP_000074166.1. NC_009800.1.

3D structure databases

ProteinModelPortaliA7ZZ10.
SMRiA7ZZ10. Positions 144-173, 278-393.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV05514; ABV05514; EcHS_A1175.
KEGGiecx:EcHS_A1175.
PATRICi18312330. VBIEscCol77814_1140.

Phylogenomic databases

HOGENOMiHOG000066093.
KOiK08161.
OMAiFITTMII.
OrthoDBiEOG6VF34T.

Enzyme and pathway databases

BioCyciECOL331112:GHHI-1167-MONOMER.

Family and domain databases

HAMAPiMF_01528. MFS_MdtG.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HS.

Entry informationi

Entry nameiMDTG_ECOHS
AccessioniPrimary (citable) accession number: A7ZZ10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: November 11, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.