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Protein

Multidrug resistance protein MdtG

Gene

mdtG

Organism
Escherichia coli O9:H4 (strain HS)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Confers resistance to fosfomycin and deoxycholate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntibiotic resistance, Transport

Enzyme and pathway databases

BioCyciECOL331112:G1G9Q-1202-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtGUniRule annotation
Gene namesi
Name:mdtGUniRule annotation
Ordered Locus Names:EcHS_A1175
OrganismiEscherichia coli O9:H4 (strain HS)
Taxonomic identifieri331112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalUniRule annotationAdd BLAST21
Transmembranei58 – 78HelicalUniRule annotationAdd BLAST21
Transmembranei92 – 112HelicalUniRule annotationAdd BLAST21
Transmembranei115 – 135HelicalUniRule annotationAdd BLAST21
Transmembranei146 – 166HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21
Transmembranei224 – 244HelicalUniRule annotationAdd BLAST21
Transmembranei256 – 276HelicalUniRule annotationAdd BLAST21
Transmembranei291 – 311HelicalUniRule annotationAdd BLAST21
Transmembranei379 – 399HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168741 – 409Multidrug resistance protein MdtGAdd BLAST409

Proteomic databases

PRIDEiA7ZZ10

Structurei

3D structure databases

ProteinModelPortaliA7ZZ10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066093
KOiK08161
OMAiVIRHNVP

Family and domain databases

CDDicd06174 MFS, 1 hit
HAMAPiMF_01528 MFS_MdtG, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR023692 Mutidrug-R_MdtG
IPR001958 Tet-R_TetA/multi-R_MdtG
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PRINTSiPR01035 TCRTETA
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

A7ZZ10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPCENDTPI NWKRNLIVAW LGCFLTGAAF SLVMPFLPLY VEQLGVTGHS
60 70 80 90 100
ALNMWSGIVF SITFLFSAIA SPFWGGLADR KGRKLMLLRS ALGMGIVMVL
110 120 130 140 150
MGLAQNIWQF LILRALLGLL GGFVPNANAL IATQVPRNKS GWALGTLSTG
160 170 180 190 200
GVSGALLGPM AGGLLADSYG LRPVFFITAS VLILCFFVTL FCIREKFQPV
210 220 230 240 250
SKKEMLHMRE VVTSLKNPKL VLSLFVTTLI IQVATGSIAP ILTLYVRELA
260 270 280 290 300
GNVSNVAFIS GMIASVPGVA ALLLSAPRLG KLGDRIGPEK ILITALIFSV
310 320 330 340 350
LLLIPMSYVQ TPLQLGILRF LLGAADGALL PAVQTLLVYN SSNQIAGRIF
360 370 380 390 400
SYNQSFRDIG NVTGPLMGAA ISANYGFRAV FLVTAGVVLF NAVYSWNSLR

RRRIPQVSN
Length:409
Mass (Da):43,980
Last modified:October 23, 2007 - v1
Checksum:iB322579033237AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000802 Genomic DNA Translation: ABV05514.1
RefSeqiWP_000074166.1, NC_009800.1

Genome annotation databases

EnsemblBacteriaiABV05514; ABV05514; EcHS_A1175
KEGGiecx:EcHS_A1175

Similar proteinsi

Entry informationi

Entry nameiMDTG_ECOHS
AccessioniPrimary (citable) accession number: A7ZZ10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health