true2008-02-052024-03-2791LIPA_ECOHSThe pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates.Rasko D.A.Rosovitz M.J.Myers G.S.A.Mongodin E.F.Fricke W.F.Gajer P.Crabtree J.Sebaihia M.Thomson N.R.Chaudhuri R.Henderson I.R.Sperandio V.Ravel J.doi:10.1128/jb.00619-082008J. Bacteriol.1906881-6893NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]HSRadical_SAMAldolase class ILipoyl_synthAldolase_TIMElp3/MiaA/NifB-like_rSAMLIAS_NLipoyl_synthrSAMlipALIPOYL SYNTHASELIPOYL SYNTHASE, MITOCHONDRIALLIAS_NRadical_SAMLipoyl_synthlipoyl_synthaselipoyl_synthase_likeElp3Radical SAM enzymesRADICAL_SAMLipoyl synthase2.8.1.8Lip-synLSLipoate synthaseLipoic acid synthaseSulfur insertion protein LipAlipAEcHS_A0679Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.Belongs to the radical SAM superfamily. Lipoyl synthase family.Lipoyl synthase360721321Radical SAM core802976873799498101308124Fe-4S-S-AdoMet2007-10-23136072723afa78dd8cb0f4392bbdc68d14adc4MSKPIVMERGVKYRDADKMALIPVKNVATEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPQIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVKtruetrue