ID   MHPE_ECOHS              Reviewed;         337 AA.
AC   A7ZWZ9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   16-JUN-2009, entry version 12.
DE   RecName: Full=4-hydroxy-2-oxovalerate aldolase;
DE            Short=HOA;
DE            EC=4.1.3.39;
DE   AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase;
GN   Name=mhpE; OrderedLocusNames=EcHS_A0416;
OS   Escherichia coli O9:H4 (strain HS).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331112;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18676672; DOI=10.1128/JB.00619-08;
RA   Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA   Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA   Henderson I.R., Sperandio V., Ravel J.;
RT   "The pangenome structure of Escherichia coli: comparative genomic
RT   analysis of E. coli commensal and pathogenic isolates.";
RL   J. Bacteriol. 190:6881-6893(2008).
CC   -!- FUNCTION: Catalyzes the fission of 4-hydroxy-2-ketovalerate to
CC       yield pyruvate and acetaldehyde (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxy-2-oxopentanoate = acetaldehyde +
CC       pyruvate.
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropionic acid
CC       degradation.
CC   -!- SUBUNIT: Interacts with mhpF (By similarity).
CC   -!- SIMILARITY: Belongs to the mhpE aldolase family.
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DR   EMBL; CP000802; ABV04803.1; -; Genomic_DNA.
DR   RefSeq; YP_001457186.1; -.
DR   GeneID; 5595038; -.
DR   GenomeReviews; CP000802_GR; EcHS_A0416.
DR   KEGG; ecx:EcHS_A0416; -.
DR   OMA; A7ZWZ9; ATCVYVV.
DR   GO; GO:0008701; F:4-hydroxy-2-oxovalerate aldolase activity; IEA:HAMAP.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:HAMAP.
DR   HAMAP; MF_01656; -; 1.
DR   InterPro; IPR017629; 4OH_2_O-val_aldolase.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012425; DmpG_comm.
DR   InterPro; IPR000891; PYR_CT.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF07836; DmpG_comm; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   TIGRFAMs; TIGR03217; 4OH_2_O_val_ald; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Complete proteome; Lyase.
FT   CHAIN         1    337       4-hydroxy-2-oxovalerate aldolase.
FT                                /FTId=PRO_0000337806.
SQ   SEQUENCE   337 AA;  36479 MW;  1DAC59F891FEFC9B CRC64;
     MNGKKLYISD VTLRDGMHAI RHQYSLENVR HIAKALDDAR VDSIEVAHGD GLQGSSFNYG
     FGAHSDLEWI EAAADVVKHA KIATLLLPGI GTIHDLKNAW QAGARVVRVA THCTEADVSA
     QHIQYARELG MDTVGFLMMS HMTTPENLAK QAKLMEGYGA TCIYVVDSGG AMNMSDIRDR
     FRALKAELKP ETQTGMHAHH NLSLGVANSI AAVEEGCDRI DASLAGMGAG AGNAPLEVFI
     AAADKLGWQH GTDLYALMDA ADDLVRPLQD RPVRVDRETL ALGYAGVYSS FLRHCETAAA
     RYGLSAVDIL VELGKRRMVG GQEDMIVDVA LDLRNNK
//