Reviewed, UniProtKB/Swiss-Prot A7ZWZ9 (MHPE_ECOHS)

Names and origin

Protein names

Recommended name:
    4-hydroxy-2-oxovalerate aldolase
      Short name=HOA
    EC=4.1.3.39
Alternative name(s):
    4-hydroxy-2-keto-pentanoic acid aldolase

Gene names

Name:	mhpE
Ordered Locus Names:	EcHS_A0416

Organism

Escherichia coli O9:H4 (strain HS) [Complete proteome] [HAMAP]

Taxonomic identifier

331112 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the fission of 4-hydroxy-2-ketovalerate to yield pyruvate and acetaldehyde By similarity.
Catalytic activity	4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. HAMAP MF_01656
Pathway	Aromatic compound metabolism; 3-phenylpropionic acid degradation. HAMAP MF_01656
Subunit structure	Interacts with mhpF By similarity.
Sequence similarities	Belongs to the mhpE aldolase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	4-hydroxy-2-oxovalerate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	4-hydroxy-2-oxovalerate aldolase HAMAP MF_01656		PRO_0000337806

Sequences

	Sequence		Length	Mass (Da)
	A7ZWZ9-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 1DAC59F891FEFC9B	FASTA	337	36,479
	10 20 30 40 50 60 MNGKKLYISD VTLRDGMHAI RHQYSLENVR HIAKALDDAR VDSIEVAHGD GLQGSSFNYG 70 80 90 100 110 120 FGAHSDLEWI EAAADVVKHA KIATLLLPGI GTIHDLKNAW QAGARVVRVA THCTEADVSA 130 140 150 160 170 180 QHIQYARELG MDTVGFLMMS HMTTPENLAK QAKLMEGYGA TCIYVVDSGG AMNMSDIRDR 190 200 210 220 230 240 FRALKAELKP ETQTGMHAHH NLSLGVANSI AAVEEGCDRI DASLAGMGAG AGNAPLEVFI 250 260 270 280 290 300 AAADKLGWQH GTDLYALMDA ADDLVRPLQD RPVRVDRETL ALGYAGVYSS FLRHCETAAA 310 320 330 RYGLSAVDIL VELGKRRMVG GQEDMIVDVA LDLRNNK

References

[1]

"The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates." Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J. J. Bacteriol. 190:6881-6893(2008) [PubMed: 18676672] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000802 Genomic DNA. Translation: ABV04803.1.
RefSeq	YP_001457186.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5595038.
GenomeReviews	Gene locus EcHS_A0416 in contig CP000802_GR.
KEGG	ecx:EcHS_A0416.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A7ZWZ9. ATCVYVV.
Family and domain databases
HAMAP	MF_01656. [Tree]
InterPro	IPR017629. 4OH_2_O-val_aldolase. IPR013785. Aldolase_TIM. IPR012425. DmpG_comm. IPR000891. PYR_CT. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF07836. DmpG_comm. 1 hit. PF00682. HMGL-like. 1 hit. [Graphical view]
TIGRFAMs	TIGR03217. 4OH_2_O_val_ald. 1 hit.
PROSITE	PS50991. PYR_CT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MHPE_ECOHS

Accession

Primary (citable) accession number: A7ZWZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	October 23, 2007
Last modified:	June 16, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)