A7ZVS7 (DEOD_ECO24) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Purine nucleoside phosphorylase DeoD-type
Short name=PNP
EC=2.4.2.1

Gene names

Name:	deoD
Ordered Locus Names:	EcE24377A_4983

Organism

Escherichia coli O139:H28 (strain E24377A / ETEC) [Complete proteome] [HAMAP]

Taxonomic identifier

331111 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01627
Subunit structure	Homohexamer By similarity.
Sequence similarities	Belongs to the PNP/UDP phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleoside metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	purine-nucleoside phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Purine nucleoside phosphorylase DeoD-type HAMAP-Rule MF_01627		PRO_1000069625
Amino acid modifications
	Modified residue	27	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7ZVS7 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 71D3DFAA5A176970	FASTA	239	25,950
	10 20 30 40 50 60 MATPHINAEM GDFADVVLMP GDPLRAKYIA ETFLEDAREV NNVRGMLGFT GTYKGRKISV 70 80 90 100 110 120 MGHGMGIPSC SIYTKELITD FGVKKIIRVG SCGAVLPHVK LRDVVIGMGA CTDSKVNRIR 130 140 150 160 170 180 FKDHDFAAIA DFDMVRNAVD AAKALGIDAR VGNLFSADLF YSPDGEMFDV MEKYGILGVE 190 200 210 220 230 MEAAGIYGVA AEFGAKALTI CTVSDHIRTH EQTTAAERQT TFNDMIKIAL ESVLLGDKE

References

[1]

"The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates." Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J. J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E24377A / ETEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000800 Genomic DNA. Translation: ABV17365.1.
RefSeq	YP_001465906.1. NC_009801.1.
3D structure databases
ProteinModelPortal	A7ZVS7.
SMR	A7ZVS7. Positions 2-238.
ModBase	Search...
Protein-protein interaction databases
STRING	331111.EcE24377A_4983.
Proteomic databases
PRIDE	A7ZVS7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV17365; ABV17365; EcE24377A_4983.
GeneID	5588156.
KEGG	ecw:EcE24377A_4983.
PATRIC	18299221. VBIEscCol31211_5177.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0813.
HOGENOM	HOG000274896.
KO	K03784.
OMA	SFETHAF.
ProtClustDB	PRK05819.
Enzyme and pathway databases
BioCyc	ECOL331111:GH7P-4962-MONOMER.
Family and domain databases
HAMAP	MF_01627. Pur_nucleosid_phosp.
InterPro	IPR004402. DeoD-type. IPR018017. Nucleoside_phosphorylase. IPR018016. Nucleoside_phosphorylase_CS. IPR000845. Nucleoside_phosphorylase_d. [Graphical view]
PANTHER	PTHR21234. PTHR21234. 1 hit.
Pfam	PF01048. PNP_UDP_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00107. deoD. 1 hit.
PROSITE	PS01232. PNP_UDP_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DEOD_ECO24

Accession

Primary (citable) accession number: A7ZVS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program