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Protein

Aspartate ammonia-lyase

Gene

aspA

Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate = fumarate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciECOL331111:GH7P-4675-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate ammonia-lyaseUniRule annotation (EC:4.3.1.1UniRule annotation)
Short name:
AspartaseUniRule annotation
Gene namesi
Name:aspAImported
Ordered Locus Names:EcE24377A_4694Imported
OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)Imported
Taxonomic identifieri331111 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001122 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA7ZV08.
SMRiA7ZV08. Positions 1-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 345333Lyase_1InterPro annotationAdd
BLAST
Domaini411 – 46454FumaraseC_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000061737.
KOiK01744.
OMAiEICENYV.
OrthoDBiEOG6V1M4M.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZV08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNIRIEED LLGTREVPAD AYYGVHTLRA IENFYISNNK ISDIPEFVRG
60 70 80 90 100
MVMVKKAAAM ANKELQTIPK SVANAIIAAC DEVLNNGKCM DQFPVDVYQG
110 120 130 140 150
GAGTSVNMNT NEVLANIGLE LMGHQKGEYQ YLNPNDHVNK CQSTNDAYPT
160 170 180 190 200
GFRIAVYSSL IKLVDAINQL REGFERKAVE FQDILKMGRT QLQDAVPMTL
210 220 230 240 250
GQEFRAFSIL LKEEVKNIQR TAELLLEVNL GATAIGTGLN TPKEYSPLAV
260 270 280 290 300
KKLAEVTGFP CLPAEDLIEA TSDCGAYVMV HGALKRLAVK MSKICNDLRL
310 320 330 340 350
LSSGPRAGLN EINLPELQAG SSIMPAKVNP VVPEVVNQVC FKVIGNDTTV
360 370 380 390 400
TMAAEAGQLQ LNVMEPVIGQ AMFESVHILT NACYNLLEKC INGITANKEV
410 420 430 440 450
CEGYVYNSIG IVTYLNPFIG HHNGDIVGKI CAETGKSVRE VVLERGLLTE
460 470
AELDDIFSVQ NLMHPAYKAK RYTDESEQ
Length:478
Mass (Da):52,370
Last modified:October 23, 2007 - v1
Checksum:i56A6FC7DFE96EDAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA. Translation: ABV18817.1.
RefSeqiWP_012139761.1. NC_009801.1.

Genome annotation databases

EnsemblBacteriaiABV18817; ABV18817; EcE24377A_4694.
KEGGiecw:EcE24377A_4694.
PATRICi18298656. VBIEscCol31211_4902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA. Translation: ABV18817.1.
RefSeqiWP_012139761.1. NC_009801.1.

3D structure databases

ProteinModelPortaliA7ZV08.
SMRiA7ZV08. Positions 1-460.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV18817; ABV18817; EcE24377A_4694.
KEGGiecw:EcE24377A_4694.
PATRICi18298656. VBIEscCol31211_4902.

Phylogenomic databases

HOGENOMiHOG000061737.
KOiK01744.
OMAiEICENYV.
OrthoDBiEOG6V1M4M.

Enzyme and pathway databases

BioCyciECOL331111:GH7P-4675-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E24377A / ETECImported.

Entry informationi

Entry nameiA7ZV08_ECO24
AccessioniPrimary (citable) accession number: A7ZV08
Entry historyi
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: March 16, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.