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Reviewed, UniProtKB/Swiss-Prot A7ZUD2 (CDH_ECO24)

Last modified June 16, 2009. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CDP-diacylglycerol pyrophosphatase
    EC=3.6.1.26
Alternative name(s):
    CDP-diacylglycerol phosphatidylhydrolase
    CDP-diglyceride hydrolase
Gene names
Name: cdh
Ordered Locus Names: EcE24377A_4452
OrganismEscherichia coli O139:H28 (strain E24377A / ETEC) [Complete proteome] [HAMAP]
Taxonomic identifier331111 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319

Pathway

Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319

Subcellular location

Cell inner membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the cdh family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionCDP-diacylglycerol diphosphatase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251CDP-diacylglycerol pyrophosphatase HAMAP MF_00319
PRO_1000059463

Regions

Transmembrane4 – 2421 Potential

Sequences

Sequence LengthMass (Da)Tools
A7ZUD2-1 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: C987D3A4B12BE5F3

FASTA25128,383
        10         20         30         40         50         60 
MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ NPSPCAEVKP 

        70         80         90        100        110        120 
NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQARDF MSKKYGQPVP 

       130        140        150        160        170        180 
DRAVSLAINS RTGRTQNHFH IHISCIRPDV REQLDNNLAN ISSRWLPLPG GLRGHEYLAR 

       190        200        210        220        230        240 
RVTESELVQR SPFMMLAEEV PEAREHMGSY GLAMVRQSDN SFVLLATQRN LLTLNRASAE 

       250 
EIQDHQCEIL R 

« Hide

References

[1]"The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
J. Bacteriol. 190:6881-6893(2008) [PubMed: 18676672] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000800 Genomic DNA. Translation: ABV17277.1.
RefSeqYP_001465411.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5590584.
GenomeReviewsGene locus EcE24377A_4452 in contig CP000800_GR.
KEGGecw:EcE24377A_4452.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAA7ZUD2. EIQDHEC.

Family and domain databases

HAMAPMF_00319.
[Tree]
InterProIPR003763. CDP-diacylglyc_Pase_bac.
IPR015993. CDP-diacylglyc_Pase_proteobac.
[Graphical view]
PfamPF02611. CDH. 1 hit.
[Graphical view]
PIRSFPIRSF001273. CDH. 1 hit.
TIGRFAMsTIGR00672. cdh. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDH_ECO24
AccessionPrimary (citable) accession number: A7ZUD2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: June 16, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents