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Protein

HTH-type transcriptional activator RhaR

Gene

rhaR

Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates expression of the rhaSR operon in response to L-rhamnose.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 214H-T-H motifUniRule annotationAdd BLAST20
DNA bindingi244 – 267H-T-H motifUniRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processRhamnose metabolism, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaRUniRule annotation
Alternative name(s):
L-rhamnose operon transcriptional activator RhaRUniRule annotation
Gene namesi
Name:rhaRUniRule annotation
Ordered Locus Names:EcE24377A_4439
OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)
Taxonomic identifieri331111 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001122 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168951 – 282HTH-type transcriptional activator RhaRAdd BLAST282

Interactioni

Subunit structurei

Binds DNA as a dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei246Interaction with sigma-70UniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliA7ZUB8
SMRiA7ZUB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000290513
KOiK02854
OMAiNREVGMT

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_01533 HTH_type_RhaR, 1 hit
InterProiView protein in InterPro
IPR003313 AraC-bd
IPR009057 Homeobox-like_sf
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
IPR023699 Tscrpt_act_RhaR
IPR020449 Tscrpt_reg_HTH_AraC-type
PfamiView protein in Pfam
PF02311 AraC_binding, 1 hit
PF12833 HTH_18, 1 hit
PRINTSiPR00032 HTHARAC
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
SSF51182 SSF51182, 1 hit
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequencei

Sequence statusi: Complete.

A7ZUB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHQLKLLKD DFFASDQQAV AVADRYPQDV FAEHTHDFCE LVIVWRGNGL
60 70 80 90 100
HVLNDRPYRI TRGDLFYIHA DDKHSYASVN DLVLQNIIYC PERLKLNLDW
110 120 130 140 150
QGAIPGFSAS AGQPHWRLGS VGMAQARQVI GQLEHESSQH VSFANEMAEL
160 170 180 190 200
LFGQLVMLLN RHRYTSDSLP PTSSETLLDK LITRLAASLK SPFALDKFCD
210 220 230 240 250
EASCSERVLR QQFRQQTGMT INQYLRQVRV CHAQYLLQHS RLLISDISTE
260 270 280
CGFEDSNYFS VVFTRETGMT PSQWRHLNSQ KD
Length:282
Mass (Da):32,304
Last modified:February 5, 2008 - v2
Checksum:iEA3E9D564149FB32
GO

Sequence cautioni

The sequence ABV18617 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA Translation: ABV18617.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiABV18617; ABV18617; EcE24377A_4439
KEGGiecw:EcE24377A_4439

Similar proteinsi

Entry informationi

Entry nameiRHAR_ECO24
AccessioniPrimary (citable) accession number: A7ZUB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health