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Protein

HTH-type transcriptional activator RhaR

Gene

rhaR

Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates expression of the rhaSR operon in response to L-rhamnose.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 214H-T-H motifUniRule annotationAdd BLAST20
DNA bindingi244 – 267H-T-H motifUniRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processRhamnose metabolism, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaRUniRule annotation
Alternative name(s):
L-rhamnose operon transcriptional activator RhaRUniRule annotation
Gene namesi
Name:rhaRUniRule annotation
Ordered Locus Names:EcE24377A_4439
OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)
Taxonomic identifieri331111 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001122 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168951 – 282HTH-type transcriptional activator RhaRAdd BLAST282

Interactioni

Subunit structurei

Binds DNA as a dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei246Interaction with sigma-70UniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliA7ZUB8.
SMRiA7ZUB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000290513.
KOiK02854.
OMAiSVVFNRE.

Family and domain databases

HAMAPiMF_01533. HTH_type_RhaR. 1 hit.
InterProiView protein in InterPro
IPR003313. AraC-bd.
IPR009057. Homeobox-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR011051. RmlC_Cupin.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
PfamiView protein in Pfam
PF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
PRINTSiPR00032. HTHARAC.
SMARTiView protein in SMART
SM00342. HTH_ARAC. 1 hit.
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51182. SSF51182. 1 hit.
PROSITEiView protein in PROSITE
PS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A7ZUB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHQLKLLKD DFFASDQQAV AVADRYPQDV FAEHTHDFCE LVIVWRGNGL
60 70 80 90 100
HVLNDRPYRI TRGDLFYIHA DDKHSYASVN DLVLQNIIYC PERLKLNLDW
110 120 130 140 150
QGAIPGFSAS AGQPHWRLGS VGMAQARQVI GQLEHESSQH VSFANEMAEL
160 170 180 190 200
LFGQLVMLLN RHRYTSDSLP PTSSETLLDK LITRLAASLK SPFALDKFCD
210 220 230 240 250
EASCSERVLR QQFRQQTGMT INQYLRQVRV CHAQYLLQHS RLLISDISTE
260 270 280
CGFEDSNYFS VVFTRETGMT PSQWRHLNSQ KD
Length:282
Mass (Da):32,304
Last modified:February 5, 2008 - v2
Checksum:iEA3E9D564149FB32
GO

Sequence cautioni

The sequence ABV18617 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA. Translation: ABV18617.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABV18617; ABV18617; EcE24377A_4439.
KEGGiecw:EcE24377A_4439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA. Translation: ABV18617.1. Different initiation.

3D structure databases

ProteinModelPortaliA7ZUB8.
SMRiA7ZUB8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV18617; ABV18617; EcE24377A_4439.
KEGGiecw:EcE24377A_4439.

Phylogenomic databases

HOGENOMiHOG000290513.
KOiK02854.
OMAiSVVFNRE.

Family and domain databases

HAMAPiMF_01533. HTH_type_RhaR. 1 hit.
InterProiView protein in InterPro
IPR003313. AraC-bd.
IPR009057. Homeobox-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR011051. RmlC_Cupin.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
PfamiView protein in Pfam
PF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
PRINTSiPR00032. HTHARAC.
SMARTiView protein in SMART
SM00342. HTH_ARAC. 1 hit.
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51182. SSF51182. 1 hit.
PROSITEiView protein in PROSITE
PS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHAR_ECO24
AccessioniPrimary (citable) accession number: A7ZUB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 7, 2017
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.