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A7ZU40 (UBIE_ECO24) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

EC=2.1.1.163
EC=2.1.1.201
Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Demethylmenaquinone methyltransferase
Gene names
Name:ubiE
Ordered Locus Names:EcE24377A_4354
OrganismEscherichia coli O139:H28 (strain E24377A / ETEC) [Complete proteome] [HAMAP]
Taxonomic identifier331111 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) By similarity. HAMAP-Rule MF_01813

Catalytic activity

A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine. HAMAP-Rule MF_01813

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol. HAMAP-Rule MF_01813

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 8/8. HAMAP-Rule MF_01813

Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP-Rule MF_01813

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family.

Ontologies

Keywords
   Biological processMenaquinone biosynthesis
Ubiquinone biosynthesis
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmenaquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

ubiquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE HAMAP-Rule MF_01813
PRO_1000070197

Sequences

Sequence LengthMass (Da)Tools
A7ZU40 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: B1EEE209BDC68F5E

FASTA25128,073
        10         20         30         40         50         60 
MVDKSQETTH FGFQTVAKEQ KADMVAHVFH SVASKYDVMN DLMSFGIHRL WKRFTIDCSG 

        70         80         90        100        110        120 
VRRGQTVLDL AGGTGDLTAK FSRLVGETGK VVLADINESM LKMGREKLRN IGVIGNVEYV 

       130        140        150        160        170        180 
QANAEALPFP DNTFDCITIS FGLRNVTDKD KALRSMYRVL KPGGRLLVLE FSKPIIEPLS 

       190        200        210        220        230        240 
KAYDAYSFHV LPRIGSLVAN DADSYRYLAE SIRMHPDQDT LKAMMQDAGF ESVDYYNLTA 

       250 
GVVALHRGYK F 

« Hide

References

[1]"The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: E24377A / ETEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000800 Genomic DNA. Translation: ABV18496.1.
RefSeqYP_001465319.1. NC_009801.1.

3D structure databases

ProteinModelPortalA7ZU40.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING331111.EcE24377A_4354.

Proteomic databases

PRIDEA7ZU40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV18496; ABV18496; EcE24377A_4354.
GeneID5589519.
KEGGecw:EcE24377A_4354.
PATRIC18297974. VBIEscCol31211_4580.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2226.
HOGENOMHOG000249463.
KOK03183.
OMAIWKRFTI.
OrthoDBEOG6M6JSB.

Enzyme and pathway databases

BioCycECOL331111:GH7P-4332-MONOMER.
UniPathwayUPA00079; UER00169.
UPA00232.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
HAMAPMF_01813. UbiE_methyltran.
InterProIPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
TIGRFAMsTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBIE_ECO24
AccessionPrimary (citable) accession number: A7ZU40
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways