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A7ZU40

- UBIE_ECO24

UniProt

A7ZU40 - UBIE_ECO24

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Protein

Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

Gene
ubiE, EcE24377A_4354
Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) By similarity.UniRule annotation

Catalytic activityi

A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation
S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
  2. ubiquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Menaquinone biosynthesis, Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciECOL331111:GH7P-4332-MONOMER.
UniPathwayiUPA00079; UER00169.
UPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (EC:2.1.1.163, EC:2.1.1.201)
Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Demethylmenaquinone methyltransferase
Gene namesi
Name:ubiE
Ordered Locus Names:EcE24377A_4354
OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)
Taxonomic identifieri331111 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001122: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotationPRO_1000070197Add
BLAST

Proteomic databases

PRIDEiA7ZU40.

Interactioni

Protein-protein interaction databases

STRINGi331111.EcE24377A_4354.

Structurei

3D structure databases

ProteinModelPortaliA7ZU40.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2226.
HOGENOMiHOG000249463.
KOiK03183.
OMAiIWKRFTI.
OrthoDBiEOG6M6JSB.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. UbiE_methyltran.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZU40-1 [UniParc]FASTAAdd to Basket

« Hide

MVDKSQETTH FGFQTVAKEQ KADMVAHVFH SVASKYDVMN DLMSFGIHRL    50
WKRFTIDCSG VRRGQTVLDL AGGTGDLTAK FSRLVGETGK VVLADINESM 100
LKMGREKLRN IGVIGNVEYV QANAEALPFP DNTFDCITIS FGLRNVTDKD 150
KALRSMYRVL KPGGRLLVLE FSKPIIEPLS KAYDAYSFHV LPRIGSLVAN 200
DADSYRYLAE SIRMHPDQDT LKAMMQDAGF ESVDYYNLTA GVVALHRGYK 250
F 251
Length:251
Mass (Da):28,073
Last modified:October 23, 2007 - v1
Checksum:iB1EEE209BDC68F5E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000800 Genomic DNA. Translation: ABV18496.1.
RefSeqiYP_001465319.1. NC_009801.1.

Genome annotation databases

EnsemblBacteriaiABV18496; ABV18496; EcE24377A_4354.
GeneIDi5589519.
KEGGiecw:EcE24377A_4354.
PATRICi18297974. VBIEscCol31211_4580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000800 Genomic DNA. Translation: ABV18496.1 .
RefSeqi YP_001465319.1. NC_009801.1.

3D structure databases

ProteinModelPortali A7ZU40.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331111.EcE24377A_4354.

Proteomic databases

PRIDEi A7ZU40.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV18496 ; ABV18496 ; EcE24377A_4354 .
GeneIDi 5589519.
KEGGi ecw:EcE24377A_4354.
PATRICi 18297974. VBIEscCol31211_4580.

Phylogenomic databases

eggNOGi COG2226.
HOGENOMi HOG000249463.
KOi K03183.
OMAi IWKRFTI.
OrthoDBi EOG6M6JSB.

Enzyme and pathway databases

UniPathwayi UPA00079 ; UER00169 .
UPA00232 .
BioCyci ECOL331111:GH7P-4332-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01813. UbiE_methyltran.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view ]
Pfami PF01209. Ubie_methyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEi PS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E24377A / ETEC.

Entry informationi

Entry nameiUBIE_ECO24
AccessioniPrimary (citable) accession number: A7ZU40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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