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Protein

Small heat shock protein IbpB

Gene

ibpB

Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciECOL331111:GH7P-4170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small heat shock protein IbpBUniRule annotation
Alternative name(s):
16 kDa heat shock protein BUniRule annotation
Gene namesi
Name:ibpBUniRule annotation
Ordered Locus Names:EcE24377A_4194
OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)
Taxonomic identifieri331111 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001122 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Small heat shock protein IbpBPRO_1000070880Add
BLAST

Interactioni

Subunit structurei

Homodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA7ZTP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.UniRule annotation

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000251750.
KOiK04081.
OMAiRQFQRSF.
OrthoDBiEOG65TRT6.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
HAMAPiMF_02001. HSP20_IbpB.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
IPR022848. HSP20_IbpB.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZTP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNFDLSPLM RQWIGFDKLA NALQNAGESQ SFPPYNIEKS DDNHYRITLA
60 70 80 90 100
LAGFRQEDLE IQLEGTRLSV KGTPEQPKEE KKWLHQGLMN QPFSLSFTLA
110 120 130 140
ENMEVSGATF VNGLLHIDLI RNEPEPIAAQ RIAISERPAL NS
Length:142
Mass (Da):16,093
Last modified:October 23, 2007 - v1
Checksum:i7666BB1BDB8A673A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA. Translation: ABV19312.1.
RefSeqiWP_001243431.1. NC_009801.1.

Genome annotation databases

EnsemblBacteriaiABV19312; ABV19312; EcE24377A_4194.
KEGGiecw:EcE24377A_4194.
PATRICi18297658. VBIEscCol31211_4432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA. Translation: ABV19312.1.
RefSeqiWP_001243431.1. NC_009801.1.

3D structure databases

ProteinModelPortaliA7ZTP0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV19312; ABV19312; EcE24377A_4194.
KEGGiecw:EcE24377A_4194.
PATRICi18297658. VBIEscCol31211_4432.

Phylogenomic databases

HOGENOMiHOG000251750.
KOiK04081.
OMAiRQFQRSF.
OrthoDBiEOG65TRT6.

Enzyme and pathway databases

BioCyciECOL331111:GH7P-4170-MONOMER.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
HAMAPiMF_02001. HSP20_IbpB.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
IPR022848. HSP20_IbpB.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E24377A / ETEC.

Entry informationi

Entry nameiIBPB_ECO24
AccessioniPrimary (citable) accession number: A7ZTP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: January 20, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.