Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7ZPL9

- PDXK_ECO24

UniProt

A7ZPL9 - PDXK_ECO24

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pyridoxine kinase

Gene

pdxK

Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates.UniRule annotation

Catalytic activityi

ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.UniRule annotation

Cofactori

Zn2+UniRule annotation, Mg2+UniRule annotationNote: Zinc or magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei23 – 231SubstrateUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Binding sitei233 – 2331SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 1962ATPUniRule annotation
Nucleotide bindingi220 – 23213ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glucokinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. pyridoxal kinase activity Source: UniProtKB-EC
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
  2. pyridoxal 5'-phosphate salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciECOL331111:GH7P-2686-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine kinaseUniRule annotation (EC:2.7.1.35UniRule annotation)
Alternative name(s):
PN/PL/PM kinaseUniRule annotation
Pyridoxal kinaseUniRule annotation
Pyridoxamine kinaseUniRule annotation
Vitamin B6 kinaseUniRule annotation
Gene namesi
Name:pdxKUniRule annotation
Ordered Locus Names:EcE24377A_2705
OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)
Taxonomic identifieri331111 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001122: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Pyridoxine kinasePRO_1000069881Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331111.EcE24377A_2705.

Structurei

3D structure databases

ProteinModelPortaliA7ZPL9.
SMRiA7ZPL9. Positions 2-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyridoxine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2240.
HOGENOMiHOG000258173.
KOiK00868.
OMAiDTAVYRW.
OrthoDBiEOG69PQ1X.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_01638. PdxK.
InterProiIPR013749. PM/HMP-P_kinase-1.
IPR004625. PyrdxlP_synth_PyrdxlKinase.
IPR023479. Pyridoxal_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10534. PTHR10534. 1 hit.
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00687. pyridox_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

A7ZPL9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSLLLFNDK SRALQADIVA VQSQVVYGSV GNSIAVPAIK QNGLNVFAVP
60 70 80 90 100
TVLLSNTPHY DTFYGGAIPD EWFSGYLRAL QERDALRQLR AVTTGYMGTA
110 120 130 140 150
SQIKILAEWL TALRKDHPDL LIMVDPVIGD IDSGIYVKPD LPEAYRQYLL
160 170 180 190 200
PLAQGITPNI FELEILTGKN CRDLDSAIAA AKSLLSDTLK WVVITSASGN
210 220 230 240 250
EENQEMQVVV VSADSVNVIS HSRVKTDLKG TGDLFCAQLI SGLLKGKALN
260 270 280
DAVHRAGLRV LEVMRYTQQH ESDELILPPL AEA
Length:283
Mass (Da):30,860
Last modified:October 23, 2007 - v1
Checksum:i902F8C55E5B7804B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA. Translation: ABV19738.1.
RefSeqiYP_001463748.1. NC_009801.1.

Genome annotation databases

EnsemblBacteriaiABV19738; ABV19738; EcE24377A_2705.
GeneIDi5588451.
KEGGiecw:EcE24377A_2705.
PATRICi18294680. VBIEscCol31211_2975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA. Translation: ABV19738.1 .
RefSeqi YP_001463748.1. NC_009801.1.

3D structure databases

ProteinModelPortali A7ZPL9.
SMRi A7ZPL9. Positions 2-280.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331111.EcE24377A_2705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV19738 ; ABV19738 ; EcE24377A_2705 .
GeneIDi 5588451.
KEGGi ecw:EcE24377A_2705.
PATRICi 18294680. VBIEscCol31211_2975.

Phylogenomic databases

eggNOGi COG2240.
HOGENOMi HOG000258173.
KOi K00868.
OMAi DTAVYRW.
OrthoDBi EOG69PQ1X.

Enzyme and pathway databases

BioCyci ECOL331111:GH7P-2686-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_01638. PdxK.
InterProi IPR013749. PM/HMP-P_kinase-1.
IPR004625. PyrdxlP_synth_PyrdxlKinase.
IPR023479. Pyridoxal_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
PANTHERi PTHR10534. PTHR10534. 1 hit.
Pfami PF08543. Phos_pyr_kin. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00687. pyridox_kin. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E24377A / ETEC.

Entry informationi

Entry nameiPDXK_ECO24
AccessioniPrimary (citable) accession number: A7ZPL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3