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A7ZPL9 (PDXK_ECO24) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyridoxine kinase

EC=2.7.1.35
Alternative name(s):
PN/PL/PM kinase
Pyridoxal kinase
Pyridoxamine kinase
Vitamin B6 kinase
Gene names
Name:pdxK
Ordered Locus Names:EcE24377A_2705
OrganismEscherichia coli O139:H28 (strain E24377A / ETEC) [Complete proteome] [HAMAP]
Taxonomic identifier331111 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates By similarity. HAMAP-Rule MF_01638

Catalytic activity

ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. HAMAP-Rule MF_01638

Cofactor

Zinc or magnesium By similarity. HAMAP-Rule MF_01638

Sequence similarities

Belongs to the pyridoxine kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Pyridoxine kinase HAMAP-Rule MF_01638
PRO_1000069881

Regions

Nucleotide binding195 – 1962ATP By similarity
Nucleotide binding220 – 23213ATP By similarity

Sites

Binding site231Substrate By similarity
Binding site1361Substrate By similarity
Binding site2331Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A7ZPL9 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 902F8C55E5B7804B

FASTA28330,860
        10         20         30         40         50         60 
MSSLLLFNDK SRALQADIVA VQSQVVYGSV GNSIAVPAIK QNGLNVFAVP TVLLSNTPHY 

        70         80         90        100        110        120 
DTFYGGAIPD EWFSGYLRAL QERDALRQLR AVTTGYMGTA SQIKILAEWL TALRKDHPDL 

       130        140        150        160        170        180 
LIMVDPVIGD IDSGIYVKPD LPEAYRQYLL PLAQGITPNI FELEILTGKN CRDLDSAIAA 

       190        200        210        220        230        240 
AKSLLSDTLK WVVITSASGN EENQEMQVVV VSADSVNVIS HSRVKTDLKG TGDLFCAQLI 

       250        260        270        280 
SGLLKGKALN DAVHRAGLRV LEVMRYTQQH ESDELILPPL AEA 

« Hide

References

[1]"The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: E24377A / ETEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000800 Genomic DNA. Translation: ABV19738.1.
RefSeqYP_001463748.1. NC_009801.1.

3D structure databases

ProteinModelPortalA7ZPL9.
SMRA7ZPL9. Positions 2-280.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING331111.EcE24377A_2705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV19738; ABV19738; EcE24377A_2705.
GeneID5588451.
KEGGecw:EcE24377A_2705.
PATRIC18294680. VBIEscCol31211_2975.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2240.
HOGENOMHOG000258173.
KOK00868.
OMADTAVYRW.
OrthoDBEOG69PQ1X.

Enzyme and pathway databases

BioCycECOL331111:GH7P-2686-MONOMER.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_01638. PdxK.
InterProIPR013749. HMP-P_kinase-1.
IPR004625. PyrdxlP_synth_PyrdxlKinase.
IPR023479. Pyridoxal_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERPTHR10534. PTHR10534. 1 hit.
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00687. pyridox_kin. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXK_ECO24
AccessionPrimary (citable) accession number: A7ZPL9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families