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A7ZPL9

- PDXK_ECO24

UniProt

A7ZPL9 - PDXK_ECO24

Protein

Pyridoxine kinase

Gene

pdxK

Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates.UniRule annotation

    Catalytic activityi

    ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.UniRule annotation

    Cofactori

    Zinc or magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei23 – 231SubstrateUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Binding sitei233 – 2331SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi195 – 1962ATPUniRule annotation
    Nucleotide bindingi220 – 23213ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glucokinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. pyridoxal kinase activity Source: UniProtKB-EC
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP
    2. pyridoxal 5'-phosphate salvage Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciECOL331111:GH7P-2686-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridoxine kinaseUniRule annotation (EC:2.7.1.35UniRule annotation)
    Alternative name(s):
    PN/PL/PM kinaseUniRule annotation
    Pyridoxal kinaseUniRule annotation
    Pyridoxamine kinaseUniRule annotation
    Vitamin B6 kinaseUniRule annotation
    Gene namesi
    Name:pdxKUniRule annotation
    Ordered Locus Names:EcE24377A_2705
    OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)
    Taxonomic identifieri331111 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001122: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Pyridoxine kinasePRO_1000069881Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331111.EcE24377A_2705.

    Structurei

    3D structure databases

    ProteinModelPortaliA7ZPL9.
    SMRiA7ZPL9. Positions 2-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyridoxine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2240.
    HOGENOMiHOG000258173.
    KOiK00868.
    OMAiDTAVYRW.
    OrthoDBiEOG69PQ1X.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_01638. PdxK.
    InterProiIPR013749. PM/HMP-P_kinase-1.
    IPR004625. PyrdxlP_synth_PyrdxlKinase.
    IPR023479. Pyridoxal_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PANTHERiPTHR10534. PTHR10534. 1 hit.
    PfamiPF08543. Phos_pyr_kin. 1 hit.
    [Graphical view]
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00687. pyridox_kin. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7ZPL9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLLLFNDK SRALQADIVA VQSQVVYGSV GNSIAVPAIK QNGLNVFAVP    50
    TVLLSNTPHY DTFYGGAIPD EWFSGYLRAL QERDALRQLR AVTTGYMGTA 100
    SQIKILAEWL TALRKDHPDL LIMVDPVIGD IDSGIYVKPD LPEAYRQYLL 150
    PLAQGITPNI FELEILTGKN CRDLDSAIAA AKSLLSDTLK WVVITSASGN 200
    EENQEMQVVV VSADSVNVIS HSRVKTDLKG TGDLFCAQLI SGLLKGKALN 250
    DAVHRAGLRV LEVMRYTQQH ESDELILPPL AEA 283
    Length:283
    Mass (Da):30,860
    Last modified:October 23, 2007 - v1
    Checksum:i902F8C55E5B7804B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000800 Genomic DNA. Translation: ABV19738.1.
    RefSeqiYP_001463748.1. NC_009801.1.

    Genome annotation databases

    EnsemblBacteriaiABV19738; ABV19738; EcE24377A_2705.
    GeneIDi5588451.
    KEGGiecw:EcE24377A_2705.
    PATRICi18294680. VBIEscCol31211_2975.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000800 Genomic DNA. Translation: ABV19738.1 .
    RefSeqi YP_001463748.1. NC_009801.1.

    3D structure databases

    ProteinModelPortali A7ZPL9.
    SMRi A7ZPL9. Positions 2-280.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331111.EcE24377A_2705.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV19738 ; ABV19738 ; EcE24377A_2705 .
    GeneIDi 5588451.
    KEGGi ecw:EcE24377A_2705.
    PATRICi 18294680. VBIEscCol31211_2975.

    Phylogenomic databases

    eggNOGi COG2240.
    HOGENOMi HOG000258173.
    KOi K00868.
    OMAi DTAVYRW.
    OrthoDBi EOG69PQ1X.

    Enzyme and pathway databases

    BioCyci ECOL331111:GH7P-2686-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_01638. PdxK.
    InterProi IPR013749. PM/HMP-P_kinase-1.
    IPR004625. PyrdxlP_synth_PyrdxlKinase.
    IPR023479. Pyridoxal_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    PANTHERi PTHR10534. PTHR10534. 1 hit.
    Pfami PF08543. Phos_pyr_kin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00687. pyridox_kin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
      Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
      J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: E24377A / ETEC.

    Entry informationi

    Entry nameiPDXK_ECO24
    AccessioniPrimary (citable) accession number: A7ZPL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3