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A7ZLX7

- UXAB_ECO24

UniProt

A7ZLX7 - UXAB_ECO24

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Protein

Altronate oxidoreductase

Gene
uxaB, EcE24377A_1721
Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 2912NAD By similarityAdd
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. tagaturonate reductase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciECOL331111:GH7P-1708-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Altronate oxidoreductase (EC:1.1.1.58)
Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase
Gene namesi
Name:uxaB
Ordered Locus Names:EcE24377A_1721
OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)
Taxonomic identifieri331111 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001122: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Altronate oxidoreductaseUniRule annotationPRO_1000061931Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331111.EcE24377A_1721.

Structurei

3D structure databases

ProteinModelPortaliA7ZLX7.
SMRiA7ZLX7. Positions 2-482.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0246.
HOGENOMiHOG000029586.
KOiK00041.
OMAiHNTFCST.
OrthoDBiEOG6CVVB8.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00670. Altron_oxidoreduct.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

A7ZLX7-1 [UniParc]FASTAAdd to Basket

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MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV    50
VRPIETSFPP SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS 100
EYDEFLKLAH NPEMRFVFSN TTEAGISYHA GDKFDDAPAV SYPAKLTRLL 150
FERFSHFNGA LDKGWIIIPC ELIDYNGDAL RELVLRYAQE WALPEAFIQW 200
LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDGFLDT AEHFYLFVIQ 250
GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG 300
LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP 350
YIKHQLLSIA LNGMTKFRTR ILPQLLAGQK AKGTLPARLT FALAALIAFY 400
RGERNGETYP VQDDAHWLER YQQLWSQHRD RVIGTQELVA IVLAEKDHWE 450
QDLTQVPGLV EQVANDLDAI LEKGMREAVR PLC 483
Length:483
Mass (Da):54,822
Last modified:October 23, 2007 - v1
Checksum:iABF5226CB25CC297
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000800 Genomic DNA. Translation: ABV17618.1.
RefSeqiYP_001462806.1. NC_009801.1.

Genome annotation databases

EnsemblBacteriaiABV17618; ABV17618; EcE24377A_1721.
GeneIDi5588308.
KEGGiecw:EcE24377A_1721.
PATRICi18292699. VBIEscCol31211_2005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000800 Genomic DNA. Translation: ABV17618.1 .
RefSeqi YP_001462806.1. NC_009801.1.

3D structure databases

ProteinModelPortali A7ZLX7.
SMRi A7ZLX7. Positions 2-482.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331111.EcE24377A_1721.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV17618 ; ABV17618 ; EcE24377A_1721 .
GeneIDi 5588308.
KEGGi ecw:EcE24377A_1721.
PATRICi 18292699. VBIEscCol31211_2005.

Phylogenomic databases

eggNOGi COG0246.
HOGENOMi HOG000029586.
KOi K00041.
OMAi HNTFCST.
OrthoDBi EOG6CVVB8.

Enzyme and pathway databases

UniPathwayi UPA00246 .
BioCyci ECOL331111:GH7P-1708-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_00670. Altron_oxidoreduct.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E24377A / ETEC.

Entry informationi

Entry nameiUXAB_ECO24
AccessioniPrimary (citable) accession number: A7ZLX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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