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A7ZIF6

- ACPH_ECO24

UniProt

A7ZIF6 - ACPH_ECO24

Protein

Acyl carrier protein phosphodiesterase

Gene

acpH

Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.UniRule annotation

    Catalytic activityi

    Holo-[acyl-carrier-protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier-protein].UniRule annotation

    GO - Molecular functioni

    1. [acyl-carrier-protein] phosphodiesterase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciECOL331111:GH7P-432-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl carrier protein phosphodiesteraseUniRule annotation (EC:3.1.4.14UniRule annotation)
    Short name:
    ACP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:acpHUniRule annotation
    Ordered Locus Names:EcE24377A_0434
    OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)
    Taxonomic identifieri331111 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001122: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Acyl carrier protein phosphodiesterasePRO_1000070622Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331111.EcE24377A_0434.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AcpH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3124.
    HOGENOMiHOG000275880.
    KOiK08682.
    OMAiWLHRQID.
    OrthoDBiEOG6K6V7H.

    Family and domain databases

    HAMAPiMF_01950. AcpH.
    InterProiIPR007431. ACP_phosphodiesterase.
    IPR023491. ACP_phosphodiesterase_gpbac.
    [Graphical view]
    PfamiPF04336. DUF479. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011489. DUF479. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7ZIF6-1 [UniParc]FASTAAdd to Basket

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    MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV    50
    LTDNLPEVRE AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE 100
    FVCYAREQVM TILPDSPPRF INLNNYLWSE QWLVRYRDMD FIQNVLNGMA 150
    SRRPRLDALR DSWYDLDAHY DALETRFWQF YPRMMAQASH KAL 193
    Length:193
    Mass (Da):22,942
    Last modified:October 23, 2007 - v1
    Checksum:i0DE6F0DBE1D6C523
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000800 Genomic DNA. Translation: ABV21149.1.
    RefSeqiYP_001461585.1. NC_009801.1.

    Genome annotation databases

    EnsemblBacteriaiABV21149; ABV21149; EcE24377A_0434.
    GeneIDi5590041.
    KEGGiecw:EcE24377A_0434.
    PATRICi18290126. VBIEscCol31211_0743.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000800 Genomic DNA. Translation: ABV21149.1 .
    RefSeqi YP_001461585.1. NC_009801.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331111.EcE24377A_0434.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV21149 ; ABV21149 ; EcE24377A_0434 .
    GeneIDi 5590041.
    KEGGi ecw:EcE24377A_0434.
    PATRICi 18290126. VBIEscCol31211_0743.

    Phylogenomic databases

    eggNOGi COG3124.
    HOGENOMi HOG000275880.
    KOi K08682.
    OMAi WLHRQID.
    OrthoDBi EOG6K6V7H.

    Enzyme and pathway databases

    BioCyci ECOL331111:GH7P-432-MONOMER.

    Family and domain databases

    HAMAPi MF_01950. AcpH.
    InterProi IPR007431. ACP_phosphodiesterase.
    IPR023491. ACP_phosphodiesterase_gpbac.
    [Graphical view ]
    Pfami PF04336. DUF479. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011489. DUF479. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
      Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
      J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: E24377A / ETEC.

    Entry informationi

    Entry nameiACPH_ECO24
    AccessioniPrimary (citable) accession number: A7ZIF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3