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Protein

Acyl carrier protein phosphodiesterase

Gene

acpH

Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.UniRule annotation

Catalytic activityi

Holo-[acyl-carrier-protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier-protein].UniRule annotation

GO - Molecular functioni

  1. [acyl-carrier-protein] phosphodiesterase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciECOL331111:GH7P-432-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein phosphodiesteraseUniRule annotation (EC:3.1.4.14UniRule annotation)
Short name:
ACP phosphodiesteraseUniRule annotation
Gene namesi
Name:acpHUniRule annotation
Ordered Locus Names:EcE24377A_0434
OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)
Taxonomic identifieri331111 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001122: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Acyl carrier protein phosphodiesterasePRO_1000070622Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331111.EcE24377A_0434.

Family & Domainsi

Sequence similaritiesi

Belongs to the AcpH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3124.
HOGENOMiHOG000275880.
KOiK08682.
OMAiHFLAKNW.
OrthoDBiEOG6K6V7H.

Family and domain databases

HAMAPiMF_01950. AcpH.
InterProiIPR007431. ACP_phosphodiesterase.
IPR023491. ACP_phosphodiesterase_gpbac.
[Graphical view]
PfamiPF04336. DUF479. 1 hit.
[Graphical view]
PIRSFiPIRSF011489. DUF479. 1 hit.

Sequencei

Sequence statusi: Complete.

A7ZIF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV
60 70 80 90 100
LTDNLPEVRE AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE
110 120 130 140 150
FVCYAREQVM TILPDSPPRF INLNNYLWSE QWLVRYRDMD FIQNVLNGMA
160 170 180 190
SRRPRLDALR DSWYDLDAHY DALETRFWQF YPRMMAQASH KAL
Length:193
Mass (Da):22,942
Last modified:October 23, 2007 - v1
Checksum:i0DE6F0DBE1D6C523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA. Translation: ABV21149.1.
RefSeqiYP_001461585.1. NC_009801.1.

Genome annotation databases

EnsemblBacteriaiABV21149; ABV21149; EcE24377A_0434.
GeneIDi5590041.
KEGGiecw:EcE24377A_0434.
PATRICi18290126. VBIEscCol31211_0743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA. Translation: ABV21149.1.
RefSeqiYP_001461585.1. NC_009801.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi331111.EcE24377A_0434.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV21149; ABV21149; EcE24377A_0434.
GeneIDi5590041.
KEGGiecw:EcE24377A_0434.
PATRICi18290126. VBIEscCol31211_0743.

Phylogenomic databases

eggNOGiCOG3124.
HOGENOMiHOG000275880.
KOiK08682.
OMAiHFLAKNW.
OrthoDBiEOG6K6V7H.

Enzyme and pathway databases

BioCyciECOL331111:GH7P-432-MONOMER.

Family and domain databases

HAMAPiMF_01950. AcpH.
InterProiIPR007431. ACP_phosphodiesterase.
IPR023491. ACP_phosphodiesterase_gpbac.
[Graphical view]
PfamiPF04336. DUF479. 1 hit.
[Graphical view]
PIRSFiPIRSF011489. DUF479. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates."
    Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J.
    J. Bacteriol. 190:6881-6893(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E24377A / ETEC.

Entry informationi

Entry nameiACPH_ECO24
AccessioniPrimary (citable) accession number: A7ZIF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: February 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.