A7ZI95 (MHPB_ECO24) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 31.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase EC=1.13.11.16 | ||||
| Gene names |
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| Organism | Escherichia coli O139:H28 (strain E24377A / ETEC) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 331111 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 314 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively By similarity. HAMAP MF_01653 |
| Catalytic activity | 3-(2,3-dihydroxyphenyl)propanoate + O2 = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. HAMAP MF_01653 (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = 2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate. HAMAP MF_01653 |
| Cofactor | Fe2+ ion By similarity. HAMAP MF_01653 |
| Pathway | Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP MF_01653 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_01653 |
| Sequence similarities | Belongs to the ligB/mhpB extradiol dioxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Aromatic hydrocarbons catabolism |
| Ligand | Iron |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-carboxyethylcatechol 2,3-dioxygenase activity Inferred from electronic annotation. Source: EC ferrous iron bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 314 | 314 | 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase HAMAP MF_01653 | PRO_0000337650 | |||||
Sites | |||||||||
| Active site | 115 | 1 | Proton donor By similarity | ||||||
| Active site | 179 | 1 | Proton acceptor By similarity | ||||||
Sequences
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References
| [1] | "The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates." Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J. J. Bacteriol. 190:6881-6893(2008) [PubMed: 18676672] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E24377A / ETEC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000800 Genomic DNA. Translation: ABV19400.1. |
| RefSeq | YP_001461524.1. NC_009801.1. |
3D structure databases | |
| ProteinModelPortal | A7ZI95. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A7ZI95. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000020664; EBESCP00000019726; EBESCG00000019718. |
| GeneID | 5589309. |
| GenomeReviews | Gene locus EcE24377A_0372 in contig CP000800_GR. |
| KEGG | ecw:EcE24377A_0372. |
| PATRIC | 18290012. VBIEscCol31211_0686. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | NOG42398. |
| GeneTree | EBGT00050000010475. |
| HOGENOM | HBG565586. |
| OMA | AHEIRTW. |
| ProtClustDB | PRK13370. |
Enzyme and pathway databases | |
| BioCyc | ECOL331111:ECE24377A_0372-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01653. MhpB. [Tree] |
| InterPro | IPR023789. DHPP/DHXA_dioxygenase. IPR004183. Xdiol_dOase_suB. [Graphical view] |
| Gene3D | G3DSA:3.40.830.10. Xdiol_dOase_3B. 2 hits. |
| KO | K05713. |
| Pfam | PF02900. LigB. 1 hit. [Graphical view] |
| SUPFAM | SSF53213. Xdiol_dOase_3B. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MHPB_ECO24 | ||||||||
| Accession | Primary (citable) accession number: A7ZI95 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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