Reviewed, UniProtKB/Swiss-Prot A7ZGD3 (PYRE_CAMC1)

Names and origin

Protein names

Recommended name:
    Orotate phosphoribosyltransferase
      Short name=OPRT
      Short name=OPRTase
    EC=2.4.2.10

Gene names

Name:	pyrE
Ordered Locus Names:	Ccon26_20120
ORF Names:	CCC13826_1866

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP]

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity.
Catalytic activity	Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208
Cofactor	Magnesium By similarity.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Magnesium
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP orotate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Orotate phosphoribosyltransferase HAMAP MF_01208		PRO_1000073105
Regions
	Region	113 – 121	9	5-phosphoribose 1-diphosphate binding By similarity
Sites
	Binding site	93	1	5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
	Binding site	117	1	Orotate By similarity
	Binding site	145	1	Orotate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7ZGD3-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 409FE8BA68DED922	FASTA	202	21,780
	10 20 30 40 50 60 MDLEKIYKDA GAYLEGHFLL SSGNHSQFYL QSAKVLEDPA LAGKLADELA AVIEKFGIKF 70 80 90 100 110 120 DSVCSPALGG ILAGYELARA AKKRFIFTER VEKVMSLRRG FEVKKGEKFI VCEDIITTGG 130 140 150 160 170 180 SALEAAHVIE SLGGEVVGFA ALANRGFCKV ANLGNDSKPN AKLPSDKPFF ALGNFEFEIY 190 200 EPEHCPLCKS GSKAIKPGSR GN

References

[1]	"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000792 Genomic DNA. Translation: EAT99095.1.
RefSeq	YP_001467841.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7ZGD3.
Genome annotation databases
GeneID	5597569.
GenomeReviews	Gene locus Ccon26_20120 in contig CP000792_GR.
KEGG	cco:CCC13826_1866.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	YLQSAKV.
Family and domain databases
HAMAP	MF_01208. [Tree]
InterPro	IPR006273. Orotate_PRibTrfase_thermus-typ. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01367. pyrE_Therm. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRE_CAMC1

Accession

Primary (citable) accession number: A7ZGD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 23, 2007
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)