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A7ZFA4 (GLYA_CAMC1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyridoxal-phosphate-dependent serine hydroxymethyltransferase
Short name=SHMT
Short name=Serine methylase
EC=2.1.2.1
Gene names
Name:glyA
Ordered Locus Names:Ccon26_16190
ORF Names:CCC13826_0226
OrganismCampylobacter concisus (strain 13826) [Complete proteome] [HAMAP]
Taxonomic identifier360104 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate serving as the one-carbon carrier By similarity.

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Pyridoxal-phosphate-dependent serine hydroxymethyltransferase
PRO_1000006228

Regions

Region120 – 1223Substrate binding By similarity

Sites

Binding site301Pyridoxal phosphate By similarity
Binding site501Pyridoxal phosphate By similarity
Binding site521Substrate By similarity
Binding site591Substrate binding By similarity
Binding site601Pyridoxal phosphate By similarity
Binding site941Pyridoxal phosphate By similarity
Binding site1161Substrate By similarity
Binding site1701Pyridoxal phosphate By similarity
Binding site1981Pyridoxal phosphate By similarity
Binding site2231Pyridoxal phosphate By similarity
Binding site2301Pyridoxal phosphate By similarity
Binding site2561Pyridoxal phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site3561Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2241N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A7ZFA4 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 4C99FF5B695D6BC6

FASTA41445,324
        10         20         30         40         50         60 
MSLQSYDKDI YDLVNLELKR QCDHLEMIAS ENFTYPEVME VMGSILTNKY AEGYPGKRYY 

        70         80         90        100        110        120 
GGCEFVDEIE QIAIDRCKEL FGCEFANVQP NSGSQANQGV YGALLNPGDK ILGMDLSHGG 

       130        140        150        160        170        180 
HLTHGAKVSS SGKMYESFFY GVELDGRINY DRVMDIAKIV KPKMIVCGAS AYTREIEFKK 

       190        200        210        220        230        240 
FREIADAVGA ILFADVAHIA GLVVAGEHQN PFPHCDVVSS TTHKTLRGPR GGIIMTNNEE 

       250        260        270        280        290        300 
YAKKINSSIF PGIQGGPLVH VIAAKAVGFK HNLSPEWKIY AKQVKANAKK LGKVLISRGF 

       310        320        330        340        350        360 
DLVSGGTDNH LILMSFLNRD FSGKDADIAL GNAGITVNKN TVPGETRSPF ITSGIRVGSP 

       370        380        390        400        410 
ALTARGMKEA EFELIANKIA DVLSDINNAS LQEKIKGELK ELAHKFIIYD KATF

« Hide

References

[1]"Genome sequence of Campylobacter concisus 13826 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13826.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000792 Genomic DNA. Translation: EAT98335.1.
RefSeqYP_001467462.1. NC_009802.1.

3D structure databases

ProteinModelPortalA7ZFA4.
SMRA7ZFA4. Positions 1-410.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7ZFA4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5596630.
GenomeReviewsGene locus Ccon26_16190 in contig CP000792_GR.
KEGGcco:CCC13826_0226.
PATRIC20029493. VBICamCon95352_1672.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0112.
HOGENOMHBG301263.
OMAGANANIA.
ProtClustDBPRK13034.

Enzyme and pathway databases

BioCycCCON360104:CCC13826_0226-MONOMER.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLYA_CAMC1
AccessionPrimary (citable) accession number: A7ZFA4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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