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A7ZEX0

- PNP_CAMC1

UniProt

A7ZEX0 - PNP_CAMC1

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi515 – 5151MagnesiumUniRule annotation
Metal bindingi521 – 5211MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCCON360104:GHAC-1564-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Ccon26_14810
ORF Names:CCC13826_0488
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Polyribonucleotide nucleotidyltransferasePRO_0000329567Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360104.CCC13826_0488.

Structurei

3D structure databases

ProteinModelPortaliA7ZEX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini581 – 64161KHUniRule annotationAdd
BLAST
Domaini672 – 73160S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiEYIINPD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZEX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQYSIEVNNQ VEIFDLNKVA KQASGAVLLR VKNTVVLATV AREDVQVEED
60 70 80 90 100
FLPLTVQYIE KAYAAGKIPG GYVKRETKPG DFETLTARII DRSLRPLFPK
110 120 130 140 150
GYAYPTQIVV MVLSADPEVD LQVVSLNAAS VALYLSDIPV NRPVCGVRVG
160 170 180 190 200
YIDDKFVINP SNSELKQSAI DLYVAGTKDE LLMIEMRSLP QQTTQLIPMV
210 220 230 240 250
AIEPMIDPSL SDSMAQKQVM NEFSEDKMVE AIDFAGKAIL RASSAYEEAF
260 270 280 290 300
KEHKKEDAAL ELKPEIENEN IAIYIDKFYK AEVKNAINQM AKSERASELG
310 320 330 340 350
KIAKQISSDE VAQKEGWDEA VITNVLGKYK KKIVREQIIN EGIRADGRGL
360 370 380 390 400
EEVRPISIET NVLPNAHGSC LFTRGQTQAL VVATLGTDSD AQMYDILTEK
410 420 430 440 450
APLVEKFMFN YNFPGFSVGE ASPLKAPGRR ELGHGNLAKR ALAPSIDLAS
460 470 480 490 500
PYTIRVVSEI LESNGSSSMA SVCGGSLALR AAGVNTQKLV AGVAMGLIFE
510 520 530 540 550
GEKHAVLTDI MGLEDHDGDM DFKVAGTSDG ITALQMDIKL GGISLEVLKE
560 570 580 590 600
ALYQAKRGRE HILALMTQAD KNIEINEDVL PKLELFNVDP SKIVDIIGQA
610 620 630 640 650
GKTIKEIIEK FEVSIDLDRE KGEVKIAGGA KKNVDAAKDY IISITSKENS
660 670 680 690 700
RSFGKKPFKH DKDRVKPTFN IGDEFTGSVK SVVDFGVFIE LKDGVDGLLH
710 720 730
ISKIKSPLNV GDQVKVCVSE QKGNKISLSL VE
Length:732
Mass (Da):80,117
Last modified:October 23, 2007 - v1
Checksum:i5EFDE418992ACEC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT99186.1.
RefSeqiWP_012140218.1. NC_009802.1.
YP_001467328.1. NC_009802.1.

Genome annotation databases

EnsemblBacteriaiEAT99186; EAT99186; CCC13826_0488.
GeneIDi5597076.
KEGGicco:CCC13826_0488.
PATRICi20029217. VBICamCon95352_1536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT99186.1 .
RefSeqi WP_012140218.1. NC_009802.1.
YP_001467328.1. NC_009802.1.

3D structure databases

ProteinModelPortali A7ZEX0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360104.CCC13826_0488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT99186 ; EAT99186 ; CCC13826_0488 .
GeneIDi 5597076.
KEGGi cco:CCC13826_0488.
PATRICi 20029217. VBICamCon95352_1536.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi EYIINPD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CCON360104:GHAC-1564-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826.

Entry informationi

Entry nameiPNP_CAMC1
AccessioniPrimary (citable) accession number: A7ZEX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3