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A7ZE60 (HEMH_CAMC1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Ccon26_12120
ORF Names:CCC13826_0053
OrganismCampylobacter concisus (strain 13826) [Complete proteome] [HAMAP]
Taxonomic identifier360104 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Ferrochelatase HAMAP MF_00323
PRO_1000119602

Sites

Metal binding1871Iron By similarity
Metal binding2681Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A7ZE60 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 0207CDD119FAA997

FASTA31736,333
        10         20         30         40         50         60 
MKKALLLLNM GGANSLDDVE IFLTNMFNDP YILGIKNKFL RKFVAFMITK GRLKTAKHNY 

        70         80         90        100        110        120 
EQIGGKSPLC ELTAKLCEKI SSLKSEFDAV DFAMNYTSPF VKDVLKKYEK FDEIVLLPLY 

       130        140        150        160        170        180 
PHHSQTTITS SLADFKKAKE ELKLKAKISL CEPFYDDDTY NKIIISHIRE AIKDTDISDV 

       190        200        210        220        230        240 
SLIFSAHSLP RKIIEKGDIY EKHINEHVQI LSKMLKEQGL NFKDVSLAYQ SRLGPVKWLE 

       250        260        270        280        290        300 
PSLNEALAKC ENKKALIYPL SFCIDNSETI FELVIEYAKL AKELSFSFYK VVECPNFSDE 

       310 
FASFILEKSK NAREFSL

« Hide

References

[1]"Genome sequence of Campylobacter concisus 13826 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13826.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000792 Genomic DNA. Translation: EAT97745.2.
RefSeqYP_001467068.1. NC_009802.1.

3D structure databases

ProteinModelPortalA7ZE60.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7ZE60.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5596353.
GenomeReviewsGene locus Ccon26_12120 in contig CP000792_GR.
KEGGcco:CCC13826_0053.
PATRIC20028651. VBICamCon95352_1255.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALLQMGGP.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycCCON360104:CCC13826_0053-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_CAMC1
AccessionPrimary (citable) accession number: A7ZE60
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 23, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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