Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7ZE39

- SYL_CAMC1

UniProt

A7ZE39 - SYL_CAMC1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei592 – 5921ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCON360104:GHAC-1261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Ccon26_11910
ORF Names:CCC13826_0074
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Leucine--tRNA ligasePRO_0000334738Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360104.CCC13826_0074.

Structurei

3D structure databases

ProteinModelPortaliA7ZE39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5411"HIGH" regionAdd
BLAST
Motifi589 – 5935"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZE39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEKRKYEPL KIEKKWQEIW DKNEEFEPKD DLSLPKKYIL SMFPYPSGRI
60 70 80 90 100
HMGHVRNYSI GDALARSYRK SGYNVLHPIG FDSFGMPAEN AAIKHKIHPK
110 120 130 140 150
IWTYENIDYM KKELASLGFS FSKKRILATS DPLYTKWEQS FFIKMFEKGL
160 170 180 190 200
VYRKNAIVNW CEYDQTVLAN EQVEDGKCWR CGNDVVQKEL PGYYFNITKY
210 220 230 240 250
ASELLDDLKL LEGKWPNQVI TMQENWIGRS YGLEFKFSLD EASKETLGGK
260 270 280 290 300
FDGFEVFTTR PDTIYGVSYT ALAPEHPIVK ALLESDKFDE NKKAKIKAIL
310 320 330 340 350
NQSPRERQAS DKDGEFLGIY VVHPLTNEKI PVWVANFILA DYGSGAIMAV
360 370 380 390 400
PAHDQRDFEF ASKFNLPIKP VVKPLEGESE GSKAYSEYGV AINSELINGL
410 420 430 440 450
SSEDAKSFII EKFEKDGLGK RITNYKLRDW GISRQRYWGA PIPVVHCKCC
460 470 480 490 500
GVVPEKEENL PIALPEDVEI TGEGNPLDKH PTWKFTKCPK CGKDAIRETD
510 520 530 540 550
TMDTFVESSW YFARFASDEK TWEQKALDEK SVNYWMNVDQ YIGGIEHAIL
560 570 580 590 600
HLLYARFFQK VLRDLGYLRD DEPFENLLTQ GMVLKDGKKM SKSKGNVVDP
610 620 630 640 650
DDIINRYGAD TARLFILFAA PPQKELEWND SAVEGAFRFL NRLWEKSQTI
660 670 680 690 700
KKIDKLPEID HESLNKDEKF ARLKIYEALK KSTEVFGDTF AFNTLIAACM
710 720 730 740 750
EALNAINAQD NDDVNAEGFF IILNLLEPIV PHIANELSEE LFGRKNFTKI
760 770 780 790 800
AVKEEVFVKD SIALAVTVNG KKRAEFEVTA SENESEILKQ AKQNVAKWLE
810 820
GKEILKEIYI KGKLVNFVIK G
Length:821
Mass (Da):94,106
Last modified:October 23, 2007 - v1
Checksum:iE00E273EF5B2431C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT97782.1.
RefSeqiYP_001467047.1. NC_009802.1.

Genome annotation databases

EnsemblBacteriaiEAT97782; EAT97782; CCC13826_0074.
GeneIDi5596212.
KEGGicco:CCC13826_0074.
PATRICi20028609. VBICamCon95352_1234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT97782.1 .
RefSeqi YP_001467047.1. NC_009802.1.

3D structure databases

ProteinModelPortali A7ZE39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360104.CCC13826_0074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT97782 ; EAT97782 ; CCC13826_0074 .
GeneIDi 5596212.
KEGGi cco:CCC13826_0074.
PATRICi 20028609. VBICamCon95352_1234.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CCON360104:GHAC-1261-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826.

Entry informationi

Entry nameiSYL_CAMC1
AccessioniPrimary (citable) accession number: A7ZE39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3