SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7ZE39

- SYL_CAMC1

UniProt

A7ZE39 - SYL_CAMC1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene
leuS, Ccon26_11910, CCC13826_0074
Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei592 – 5921ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCON360104:GHAC-1261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Ccon26_11910
ORF Names:CCC13826_0074
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Leucine--tRNA ligaseUniRule annotationPRO_0000334738Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360104.CCC13826_0074.

Structurei

3D structure databases

ProteinModelPortaliA7ZE39.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5411"HIGH" regionUniRule annotationAdd
BLAST
Motifi589 – 5935"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZE39-1 [UniParc]FASTAAdd to Basket

« Hide

MAEKRKYEPL KIEKKWQEIW DKNEEFEPKD DLSLPKKYIL SMFPYPSGRI    50
HMGHVRNYSI GDALARSYRK SGYNVLHPIG FDSFGMPAEN AAIKHKIHPK 100
IWTYENIDYM KKELASLGFS FSKKRILATS DPLYTKWEQS FFIKMFEKGL 150
VYRKNAIVNW CEYDQTVLAN EQVEDGKCWR CGNDVVQKEL PGYYFNITKY 200
ASELLDDLKL LEGKWPNQVI TMQENWIGRS YGLEFKFSLD EASKETLGGK 250
FDGFEVFTTR PDTIYGVSYT ALAPEHPIVK ALLESDKFDE NKKAKIKAIL 300
NQSPRERQAS DKDGEFLGIY VVHPLTNEKI PVWVANFILA DYGSGAIMAV 350
PAHDQRDFEF ASKFNLPIKP VVKPLEGESE GSKAYSEYGV AINSELINGL 400
SSEDAKSFII EKFEKDGLGK RITNYKLRDW GISRQRYWGA PIPVVHCKCC 450
GVVPEKEENL PIALPEDVEI TGEGNPLDKH PTWKFTKCPK CGKDAIRETD 500
TMDTFVESSW YFARFASDEK TWEQKALDEK SVNYWMNVDQ YIGGIEHAIL 550
HLLYARFFQK VLRDLGYLRD DEPFENLLTQ GMVLKDGKKM SKSKGNVVDP 600
DDIINRYGAD TARLFILFAA PPQKELEWND SAVEGAFRFL NRLWEKSQTI 650
KKIDKLPEID HESLNKDEKF ARLKIYEALK KSTEVFGDTF AFNTLIAACM 700
EALNAINAQD NDDVNAEGFF IILNLLEPIV PHIANELSEE LFGRKNFTKI 750
AVKEEVFVKD SIALAVTVNG KKRAEFEVTA SENESEILKQ AKQNVAKWLE 800
GKEILKEIYI KGKLVNFVIK G 821
Length:821
Mass (Da):94,106
Last modified:October 23, 2007 - v1
Checksum:iE00E273EF5B2431C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT97782.1.
RefSeqiYP_001467047.1. NC_009802.1.

Genome annotation databases

EnsemblBacteriaiEAT97782; EAT97782; CCC13826_0074.
GeneIDi5596212.
KEGGicco:CCC13826_0074.
PATRICi20028609. VBICamCon95352_1234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT97782.1 .
RefSeqi YP_001467047.1. NC_009802.1.

3D structure databases

ProteinModelPortali A7ZE39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360104.CCC13826_0074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT97782 ; EAT97782 ; CCC13826_0074 .
GeneIDi 5596212.
KEGGi cco:CCC13826_0074.
PATRICi 20028609. VBICamCon95352_1234.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CCON360104:GHAC-1261-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826.

Entry informationi

Entry nameiSYL_CAMC1
AccessioniPrimary (citable) accession number: A7ZE39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi