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A7ZE39

- SYL_CAMC1

UniProt

A7ZE39 - SYL_CAMC1

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei592 – 5921ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCON360104:GHAC-1261-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Ccon26_11910
    ORF Names:CCC13826_0074
    OrganismiCampylobacter concisus (strain 13826)
    Taxonomic identifieri360104 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000001121: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 821821Leucine--tRNA ligasePRO_0000334738Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360104.CCC13826_0074.

    Structurei

    3D structure databases

    ProteinModelPortaliA7ZE39.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 5411"HIGH" regionAdd
    BLAST
    Motifi589 – 5935"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7ZE39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKRKYEPL KIEKKWQEIW DKNEEFEPKD DLSLPKKYIL SMFPYPSGRI    50
    HMGHVRNYSI GDALARSYRK SGYNVLHPIG FDSFGMPAEN AAIKHKIHPK 100
    IWTYENIDYM KKELASLGFS FSKKRILATS DPLYTKWEQS FFIKMFEKGL 150
    VYRKNAIVNW CEYDQTVLAN EQVEDGKCWR CGNDVVQKEL PGYYFNITKY 200
    ASELLDDLKL LEGKWPNQVI TMQENWIGRS YGLEFKFSLD EASKETLGGK 250
    FDGFEVFTTR PDTIYGVSYT ALAPEHPIVK ALLESDKFDE NKKAKIKAIL 300
    NQSPRERQAS DKDGEFLGIY VVHPLTNEKI PVWVANFILA DYGSGAIMAV 350
    PAHDQRDFEF ASKFNLPIKP VVKPLEGESE GSKAYSEYGV AINSELINGL 400
    SSEDAKSFII EKFEKDGLGK RITNYKLRDW GISRQRYWGA PIPVVHCKCC 450
    GVVPEKEENL PIALPEDVEI TGEGNPLDKH PTWKFTKCPK CGKDAIRETD 500
    TMDTFVESSW YFARFASDEK TWEQKALDEK SVNYWMNVDQ YIGGIEHAIL 550
    HLLYARFFQK VLRDLGYLRD DEPFENLLTQ GMVLKDGKKM SKSKGNVVDP 600
    DDIINRYGAD TARLFILFAA PPQKELEWND SAVEGAFRFL NRLWEKSQTI 650
    KKIDKLPEID HESLNKDEKF ARLKIYEALK KSTEVFGDTF AFNTLIAACM 700
    EALNAINAQD NDDVNAEGFF IILNLLEPIV PHIANELSEE LFGRKNFTKI 750
    AVKEEVFVKD SIALAVTVNG KKRAEFEVTA SENESEILKQ AKQNVAKWLE 800
    GKEILKEIYI KGKLVNFVIK G 821
    Length:821
    Mass (Da):94,106
    Last modified:October 23, 2007 - v1
    Checksum:iE00E273EF5B2431C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000792 Genomic DNA. Translation: EAT97782.1.
    RefSeqiYP_001467047.1. NC_009802.1.

    Genome annotation databases

    EnsemblBacteriaiEAT97782; EAT97782; CCC13826_0074.
    GeneIDi5596212.
    KEGGicco:CCC13826_0074.
    PATRICi20028609. VBICamCon95352_1234.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000792 Genomic DNA. Translation: EAT97782.1 .
    RefSeqi YP_001467047.1. NC_009802.1.

    3D structure databases

    ProteinModelPortali A7ZE39.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360104.CCC13826_0074.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EAT97782 ; EAT97782 ; CCC13826_0074 .
    GeneIDi 5596212.
    KEGGi cco:CCC13826_0074.
    PATRICi 20028609. VBICamCon95352_1234.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CCON360104:GHAC-1261-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
      Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13826.

    Entry informationi

    Entry nameiSYL_CAMC1
    AccessioniPrimary (citable) accession number: A7ZE39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3