Reviewed, UniProtKB/Swiss-Prot A7ZDQ5 (DAPA_CAMC1)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate synthase
      Short name=DHDPS
    EC=4.2.1.52

Gene names

Name:	dapA
Ordered Locus Names:	Ccon26_10550
ORF Names:	CCC13826_0120

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP]

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the DHDPS family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	dihydrodipicolinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Dihydrodipicolinate synthase HAMAP MF_00418		PRO_0000340938
Regions
	Region	50 – 51	2	Pyruvate binding By similarity
Sites
	Active site	165	1	Schiff-base intermediate with substrate By similarity
	Binding site	109	1	Pyruvate By similarity
	Site	136	1	Involved in proton transfer during cleavage By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7ZDQ5-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: A77F1A98D09DDBFF	FASTA	297	32,504
	10 20 30 40 50 60 MKNSLQGAMT ALITPFKNQK LDEASFEKLI KRQIKHGIDV VVPVGTTGES ATLTHDEHRI 70 80 90 100 110 120 CIEIAVDACK GTNVKVLAGA GSNATHEAIG IAKFAQAHGA HGILSVAPYY NKPTQEGLYE 130 140 150 160 170 180 HYKAIANSIE IPVLLYNVPG RVGVDILPAT VFRLFKDCKN IYGIKEATGS IDRCVDLLAH 190 200 210 220 230 240 EPDLVVISGE DAINYPILSN GGKGVISVTA NLLPDQISQL THLAMNEEYK KAKLINDNLY 250 260 270 280 290 TINKTLFCES NPIPIKAAMY LAGLIDTLEY RLPLCKPSKE NFKKIEEVIK NYEIKGF

References

[1]	"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000792 Genomic DNA. Translation: EAT97642.1.
RefSeq	YP_001466913.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7ZDQ5.
Genome annotation databases
GeneID	5597379.
GenomeReviews	Gene locus Ccon26_10550 in contig CP000792_GR.
KEGG	cco:CCC13826_0120.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VAPRLMH.
Family and domain databases
HAMAP	MF_00418. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005263. DapA_synth. IPR002220. DHDPS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR12128. DHDPS. 1 hit.
Pfam	PF00701. DHDPS. 1 hit. [Graphical view]
PRINTS	PR00146. DHPICSNTHASE.
ProDom	PD001859. DHDPS. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00674. dapA. 1 hit.
PROSITE	PS00665. DHDPS_1. False negative. PS00666. DHDPS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPA_CAMC1

Accession

Primary (citable) accession number: A7ZDQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	October 23, 2007
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)