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A7ZDF2

- ASSY_CAMC1

UniProt

A7ZDF2 - ASSY_CAMC1

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Protein

Argininosuccinate synthase

Gene
argG, Ccon26_09420, CCC13826_1219
Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei91 – 911Citrulline By similarity
Binding sitei96 – 961Citrulline By similarity
Binding sitei121 – 1211ATP; via amide nitrogen By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei127 – 1271Citrulline By similarity
Binding sitei128 – 1281Aspartate By similarity
Binding sitei131 – 1311Citrulline By similarity
Binding sitei181 – 1811Citrulline By similarity
Binding sitei190 – 1901Citrulline By similarity
Binding sitei266 – 2661Citrulline By similarity
Binding sitei278 – 2781Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCON360104:GHAC-1000-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Ccon26_09420
ORF Names:CCC13826_1219
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Argininosuccinate synthaseUniRule annotationPRO_1000000386Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi360104.CCC13826_1219.

Structurei

3D structure databases

ProteinModelPortaliA7ZDF2.
SMRiA7ZDF2. Positions 7-399.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiGIKSKFD.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZDF2-1 [UniParc]FASTAAdd to Basket

« Hide

MKKDVKKVVL AYSGGLDTSI ILKWLQDEYK CEVVTFTADI GQGEELEPAR    50
KKALALGVKP ENIFIEDLRE EFVRDYVFPM FRANAIYEGE YLLGTSIARP 100
LIAKRQSEIA RLVGADGVSH GATGKGNDQV RFELGYYALG DNLTIIAPWR 150
EWDLNSREKL LAYAEKNGID ITKKPGKSPY SMDANLLHIS YEGLVLEDPS 200
HAPEDDMWRW TVSPKDAPDK SEIIEIGYEK GDPVSIDGKK MSPAEILTEL 250
NRLGAKHGIG RLDIVENRSV GMKSRGCYET PGGTIMLKAH RAIESITLDR 300
GAAHLKDEIM PKYAELVYNG YWWSPERNML QALIDKSQEH VNGSVKVELY 350
KGNVTILGRS SKDDNLFSEA YCTFEEDSVY DQKDAEGFIK LNALRFIIAR 400
KNGRKFD 407
Length:407
Mass (Da):45,795
Last modified:October 23, 2007 - v1
Checksum:i2D4BF84E176B20C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT98616.1.
RefSeqiYP_001466810.1. NC_009802.1.

Genome annotation databases

EnsemblBacteriaiEAT98616; EAT98616; CCC13826_1219.
GeneIDi5596642.
KEGGicco:CCC13826_1219.
PATRICi20028087. VBICamCon95352_0983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT98616.1 .
RefSeqi YP_001466810.1. NC_009802.1.

3D structure databases

ProteinModelPortali A7ZDF2.
SMRi A7ZDF2. Positions 7-399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360104.CCC13826_1219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT98616 ; EAT98616 ; CCC13826_1219 .
GeneIDi 5596642.
KEGGi cco:CCC13826_1219.
PATRICi 20028087. VBICamCon95352_0983.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi GIKSKFD.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci CCON360104:GHAC-1000-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826.

Entry informationi

Entry nameiASSY_CAMC1
AccessioniPrimary (citable) accession number: A7ZDF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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