Reviewed, UniProtKB/Swiss-Prot A7ZD95 (AROB_CAMC1)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	Ccon26_08850
ORF Names:	CCC13826_0087

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP]

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm By similarity HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000117475

Sequences

	Sequence		Length	Mass (Da)
	A7ZD95-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: AE969B462631644A	FASTA	345	38,751
	10 20 30 40 50 60 MQINLNLKEK ASSYKIYINE LERLELKGKV GIVTNAKVAG LHLEKLLSVL KCDEKFIISV 70 80 90 100 110 120 PDGEEYKNLT TIEQILEQLF VSKFDRSSTL IALGGGVISD MTGFAASIYE RGISFINIPT 130 140 150 160 170 180 TLLAQVDASV GGKTGVNNKF GKNLIGSFYQ PKAVFCEINF LKTLPKREFA AGMAEALKMA 190 200 210 220 230 240 ITFDKEMFSW LKSVNLDDEN LAKLVEKSIN LKARVVEQDE KEKGLRAILN YGHTFAHVIE 250 260 270 280 290 300 NETNYKEFLH GEAVAIGMNM ANRLSVRLGL MSEAQAEEIK QVLVKFDLPV SYKIENEYAF 310 320 330 340 YEAFFMDKKT KGDKINFIIA DKIGSAVIKN DVKKEDVLET LREFK

References

[1]	"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000792 Genomic DNA. Translation: EAT97321.1.
RefSeq	YP_001466753.1.
3D structure databases
SMR	A7ZD95. Positions 1-345.
ModBase	Search...
Protein-protein interaction databases
STRING	A7ZD95.
Genome annotation databases
GeneID	5595869.
GenomeReviews	Gene locus Ccon26_08850 in contig CP000792_GR.
KEGG	cco:CCC13826_0087.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0337.
HOGENOM	HBG632303.
OMA	APESMDF.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_CAMC1

Accession

Primary (citable) accession number: A7ZD95

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	October 23, 2007
Last modified:	February 9, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)