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A7ZD95 (AROB_CAMC1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Ccon26_08850
ORF Names:CCC13826_0087
OrganismCampylobacter concisus (strain 13826) [Complete proteome] [HAMAP]
Taxonomic identifier360104 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3453453-dehydroquinate synthase HAMAP MF_00110
PRO_1000117475

Sequences

Sequence LengthMass (Da)Tools
A7ZD95 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: AE969B462631644A

FASTA34538,751
        10         20         30         40         50         60 
MQINLNLKEK ASSYKIYINE LERLELKGKV GIVTNAKVAG LHLEKLLSVL KCDEKFIISV 

        70         80         90        100        110        120 
PDGEEYKNLT TIEQILEQLF VSKFDRSSTL IALGGGVISD MTGFAASIYE RGISFINIPT 

       130        140        150        160        170        180 
TLLAQVDASV GGKTGVNNKF GKNLIGSFYQ PKAVFCEINF LKTLPKREFA AGMAEALKMA 

       190        200        210        220        230        240 
ITFDKEMFSW LKSVNLDDEN LAKLVEKSIN LKARVVEQDE KEKGLRAILN YGHTFAHVIE 

       250        260        270        280        290        300 
NETNYKEFLH GEAVAIGMNM ANRLSVRLGL MSEAQAEEIK QVLVKFDLPV SYKIENEYAF 

       310        320        330        340 
YEAFFMDKKT KGDKINFIIA DKIGSAVIKN DVKKEDVLET LREFK

« Hide

References

[1]"Genome sequence of Campylobacter concisus 13826 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13826.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000792 Genomic DNA. Translation: EAT97321.1.
RefSeqYP_001466753.1. NC_009802.1.

3D structure databases

ProteinModelPortalA7ZD95.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7ZD95.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5595869.
GenomeReviewsGene locus Ccon26_08850 in contig CP000792_GR.
KEGGcco:CCC13826_0087.
PATRIC20027965. VBICamCon95352_0925.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMALGQSDFT.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycCCON360104:CCC13826_0087-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_CAMC1
AccessionPrimary (citable) accession number: A7ZD95
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 23, 2007
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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