Reviewed, UniProtKB/Swiss-Prot A7ZD85 (PUR7_CAMC1)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthase
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	Ccon26_08750
ORF Names:	CCC13826_0132

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP]

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000018678

Sequences

	Sequence		Length	Mass (Da)
	A7ZD85-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: C14C58C7EACC327C	FASTA	236	26,878
	10 20 30 40 50 60 MQKRELIYEG KGKKMYATDD PNLLVAEFKD DLTAFDAQKR GNEAGKGALN NKISTQLFKL 70 80 90 100 110 120 LESKGIVTDL VETISDTEQV VKKCEIIPLE VVVRNIATGS LSKRLGIKEG TVLPFTLVEF 130 140 150 160 170 180 YYKNDDLHDP LVTDEHCIIM GLVKSEKDLQ TLRHTAREIN SILFKFFAER NLKLVDFKVE 190 200 210 220 230 FGIDKDGNII LADEISPDSC RFWDATTNEK LDKDRFRQDL GSVKVAYEEV LRRILS

References

[1]	"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000792 Genomic DNA. Translation: EAT97504.1.
RefSeq	YP_001466743.1.
3D structure databases
SMR	A7ZD85. Positions 2-235.
ModBase	Search...
Protein-protein interaction databases
STRING	A7ZD85.
Genome annotation databases
GeneID	5596771.
GenomeReviews	Gene locus Ccon26_08750 in contig CP000792_GR.
KEGG	cco:CCC13826_0132.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HBG306070.
OMA	TAFNAQK.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. purC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_CAMC1

Accession

Primary (citable) accession number: A7ZD85

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	February 9, 2010
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)