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A7ZCZ7

- PUR9_CAMC1

UniProt

A7ZCZ7 - PUR9_CAMC1

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Ccon26_07810, CCC13826_1632
Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCCON360104:GHAC-829-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Ccon26_07810
ORF Names:CCC13826_1632
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018867Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360104.CCC13826_1632.

Structurei

3D structure databases

ProteinModelPortaliA7ZCZ7.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A7ZCZ7-1 [UniParc]FASTAAdd to Basket

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MRALLSVSDK EGIVEFAKGL EELDWQILST GGTYKLLKAE GVKATEVSEF    50
TASPEMFEGR VKTLHPKVHG GILHKRDDAT HVAQAKEHGI EGIDLVCVNL 100
YPFKETTIRT DDFAEIIENI DIGGPAMVRS AAKNFKDVLI VTSVLDYDEI 150
LKRLKEKSDD YEFRRSLMIK AFEHTAAYDS MIANYMNDRF NGGFGDARFI 200
VGSKVFDTRY GENPHQKGAL YEFDYFFTNN FRALKGEASF NNMTDINGAL 250
MLATSFDDAP AVAIIKHANP CGFAVKDTLL ESYVAALKCD PISAYGGVVA 300
INGTLDEELA KKINEIYVEV IIAANVDDAA LKVFESKKRI KIFTQDNKFL 350
VRANDKFDFK HIDGGFVFQE RDFVKDEELE NMKQMSKKFA TGSELKDAQI 400
AWKVAALTKS NCVVYVKDGA MVAIGMGMTS RVDAARAAVA KAKELKIDLS 450
GCVLASEAFF PFRDSIDIAS KVGVKCVIEP GGSIRDDEVI EAADEHGMSL 500
YFTGVRHFLH 510
Length:510
Mass (Da):56,510
Last modified:October 23, 2007 - v1
Checksum:iDF4AFCA8C9A9B2AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT97421.1.
RefSeqiYP_001466655.1. NC_009802.1.

Genome annotation databases

EnsemblBacteriaiEAT97421; EAT97421; CCC13826_1632.
GeneIDi5596305.
KEGGicco:CCC13826_1632.
PATRICi20027763. VBICamCon95352_0824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT97421.1 .
RefSeqi YP_001466655.1. NC_009802.1.

3D structure databases

ProteinModelPortali A7ZCZ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360104.CCC13826_1632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT97421 ; EAT97421 ; CCC13826_1632 .
GeneIDi 5596305.
KEGGi cco:CCC13826_1632.
PATRICi 20027763. VBICamCon95352_0824.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CCON360104:GHAC-829-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826.

Entry informationi

Entry nameiPUR9_CAMC1
AccessioniPrimary (citable) accession number: A7ZCZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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