A7ZCI3 (A7ZCI3_CAMC1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897

Gene names

Name:	gyrA HAMAP-Rule MF_01897
Ordered Locus Names:	Ccon26_06040
ORF Names:	CCC13826_0843 EMBL EAT98013.1

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP] EMBL EAT98013.1

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter concisus

Protein attributes

Sequence length	873 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743
Subunit structure	Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP-Rule MF_01897
Ligand	ATP-binding SAAS SAAS013760 HAMAP-Rule MF_01897 DNA-binding SAAS SAAS005743 HAMAP-Rule MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase HAMAP-Rule MF_01897 SAAS SAAS005743
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular_component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase type II (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	126	1	O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

	Sequence		Length	Mass (Da)
	A7ZCI3 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: BD3EB92B53007A05	FASTA	873	97,515
	10 20 30 40 50 60 MKDNLLELTQ DIASVDIEDS IKNSYLDYSM SVIVGRALPD ARDGLKPVHR RILYAMDNLG 70 80 90 100 110 120 VGSRSAYMKS ARIVGEVIGK YHPHGDTAVY DALVRMAQKF SMRYPVVDGQ GNFGSIDGDS 130 140 150 160 170 180 AAAMRYTEAR MTMLTEELLK DIDKDTVDFV PNYDDREVEP DVLPSRVPNL LLNGSSGIAV 190 200 210 220 230 240 GMATNIPPHS LDELIDGLLL LLENKEATLE EVMEFIKGPD FPTGGIIFGK KGIIEAYRTG 250 260 270 280 290 300 RGRVKLRAKT HIEKKPNKDV IVIDELPYQT NKARLIEQIA ELVKDKQIDG ISEVRDESDK 310 320 330 340 350 360 DGIRVVIELK RDAMSDIVLN NLFKSTTMES TFGVIMLAIN NKEPKVFNLI ELLKLFLNHR 370 380 390 400 410 420 KTVIIRRTIF ELEKARARAH ILEGLKIALD NIDEVIELIR NSADTAVARE GLMSKFNLSE 430 440 450 460 470 480 LQANAILDMR LSKLTGLERE KLEAELAELM AEIARLDEIL KSETLLENLI KEELLEIKNK 490 500 510 520 530 540 FKVPRVTEIV DDYDDIDIED LIPNENMVVT ITHRGYIKRV PSKQYEKQKR GGKGKVAVTT 550 560 570 580 590 600 YDDDFIESFF TSNTHDTLMF VTDRGQLYWL KVYKIPEGSR TAKGKAVVNL IQLQPDEKIK 610 620 630 640 650 660 AIIPTTDFDE SKSLAFFTKN GIVKRTNLSE FKNIRSVGVR AISLDENDEL VTALIAQTYD 670 680 690 700 710 720 DMPVTDPENE LSVESEVLEI EEIQNEIDED SANAEEDTNS GDETMLFVVT KKGMCLKFKI 730 740 750 760 770 780 SKVRQMGRTA RGVTGIKFKE PGDEVVGAAV IESNDQEILS ISQKGIGKRT TADEYRLTNR 790 800 810 820 830 840 GGKGVICMKL TSRTGDLVGV VMVDEEQDLM ALTSSGKMIR VDMQSIRKAG RNTSGVIVVN 850 860 870 VDGDDVVSIA RCPKADDGED EDEAPSEDMG LLE

References

[1]

"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13826.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000792 Genomic DNA. Translation: EAT98013.1.
RefSeq	YP_001466491.1. NC_009802.1.
3D structure databases
ProteinModelPortal	A7ZCI3.
SMR	A7ZCI3. Positions 34-489.
ModBase	Search...
Protein-protein interaction databases
STRING	360104.CCC13826_0843.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EAT98013; EAT98013; CCC13826_0843.
GeneID	5597210.
KEGG	cco:CCC13826_0843.
PATRIC	20027365. VBICamCon95352_0637.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HOG000076278.
KO	K02469.
OMA	IAQEDVV.
ProtClustDB	PRK05560.
Enzyme and pathway databases
BioCyc	CCON360104:GHAC-675-MONOMER.
Family and domain databases
Gene3D	3.30.1360.40. 1 hit. 3.90.199.10. 2 hits.
HAMAP	MF_01897. GyrA.
InterPro	IPR024946. Arg_repress_C-like. IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013760. Topo_IIA_like_dom. [Graphical view]
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. gyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A7ZCI3_CAMC1

Accession

Primary (citable) accession number: A7ZCI3

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)