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A7ZCH5

- GSA_CAMC1

UniProt

A7ZCH5 - GSA_CAMC1

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene
hemL, Ccon26_05950, CCC13826_0834
Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCCON360104:GHAC-623-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Ccon26_05950
ORF Names:CCC13826_0834
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationPRO_1000072151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi360104.CCC13826_0834.

Structurei

3D structure databases

ProteinModelPortaliA7ZCH5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiKRLMEPG.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZCH5-1 [UniParc]FASTAAdd to Basket

« Hide

MTNKEAFSEA KKYIPGGVNS PVRAFGSVGG EPVMIDHARG AYLYDVEGKK    50
YLDFIQSWGP LIFGHCDKDI EEAIISAVKQ GVSYGAPSPK ETALAKLICD 100
EFKQIDKIRF VSSGTEATMS AIRVARGYAK KDGLIKFEGC YHGHSDALLI 150
KAGSGATTYG NASSGGVPQD VVKNTFLAIY NDIESVKAIF ENNKDKIGVV 200
IIEPIAGNMG LVPADKKFLR ELRELCDKFG AVLILDEVMS GFRASRLGSY 250
PFHEVDADLV TFGKVIGGGM NVAAFGGKAK IMDCLSPEGA VYQAGTLSGN 300
PVAMSAGIAA ISKINSDVNL YVRLEKLALK LMDGFKEAAK SAGITIQTEV 350
RGSMFGYFFT DHVVKNYDDA LKSDTKLFAK FHQAMLKRGI YLAPSQFETG 400
FICDAMSEAD IDLAVNAAKE AFLEIKA 427
Length:427
Mass (Da):45,954
Last modified:October 23, 2007 - v1
Checksum:i62E8A14578822ECC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT98029.1.
RefSeqiWP_012001454.1. NC_009802.1.
YP_001466483.1. NC_009802.1.

Genome annotation databases

EnsemblBacteriaiEAT98029; EAT98029; CCC13826_0834.
GeneIDi5596485.
KEGGicco:CCC13826_0834.
PATRICi20027347. VBICamCon95352_0628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT98029.1 .
RefSeqi WP_012001454.1. NC_009802.1.
YP_001466483.1. NC_009802.1.

3D structure databases

ProteinModelPortali A7ZCH5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360104.CCC13826_0834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT98029 ; EAT98029 ; CCC13826_0834 .
GeneIDi 5596485.
KEGGi cco:CCC13826_0834.
PATRICi 20027347. VBICamCon95352_0628.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi KRLMEPG.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci CCON360104:GHAC-623-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826.

Entry informationi

Entry nameiGSA_CAMC1
AccessioniPrimary (citable) accession number: A7ZCH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 23, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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