serC

Functionⁱ

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.UniRule annotationSAAS annotation

Catalytic activityⁱ

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotationSAAS annotation

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotationSAAS annotation

Pathwayⁱ: L-serine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

D-3-phosphoglycerate dehydrogenase (serA)
Phosphoserine aminotransferase (serC)
no protein annotated in this organism

This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Pathwayⁱ: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

no protein annotated in this organism
no protein annotated in this organism
Phosphoserine aminotransferase (serC)
no protein annotated in this organism
no protein annotated in this organism

This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	42	L-glutamateUniRule annotation	1
Binding siteⁱ	101	Pyridoxal phosphateUniRule annotation	1
Binding siteⁱ	149	Pyridoxal phosphateUniRule annotation	1
Binding siteⁱ	168	Pyridoxal phosphateUniRule annotation	1
Binding siteⁱ	191	Pyridoxal phosphateUniRule annotation	1

GO - Molecular functionⁱ

O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-UniRule
pyridoxal phosphate binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

L-serine biosynthetic process Source: UniProtKB-UniRule
pyridoxine biosynthetic process Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	AminotransferaseUniRule annotationSAAS annotationImported, Transferase
Biological process	Amino-acid biosynthesis, Pyridoxine biosynthesisUniRule annotation, Serine biosynthesisUniRule annotationSAAS annotation
Ligand	Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00135; UER00197. UPA00244; UER00311.

UniPathwayⁱ

UPA00135; UER00197.
UPA00244; UER00311.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation) Alternative name(s): Phosphohydroxythreonine aminotransferaseUniRule annotation Short name: PSATUniRule annotation
Gene namesⁱ	Name:serCUniRule annotationImported ORF Names:CCC13826_1599Imported
Organismⁱ	Campylobacter concisus (strain 13826)Imported
Taxonomic identifierⁱ	360104 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter concisus
Proteomesⁱ	UP000001121 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00160

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

PTM / Processingⁱ

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	192	N6-(pyridoxal phosphate)lysineUniRule annotation		1

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGⁱ	360104.CCC13826_1599.

STRINGⁱ

360104.CCC13826_1599.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A7ZCF8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 347	Aminotran_5InterPro annotationAdd BLAST		342

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	234 – 235	Pyridoxal phosphate bindingUniRule annotation		2

Sequence similaritiesⁱ

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.SAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG4107QM1. Bacteria. COG1932. LUCA.
HOGENOMⁱ	HOG000088965.
KEGG Orthology (KO) More...KOⁱ	K00831.
OMAⁱ	GAQKNMG.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01K1.

Family and domain databases

Gene3Dⁱ	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
HAMAPⁱ	MF_00160. SerC_aminotrans_5. 1 hit.
InterProⁱ	View protein in InterPro IPR000192. Aminotrans_V_dom. IPR020578. Aminotrans_V_PyrdxlP_BS. IPR022278. Pser_aminoTfrase. IPR015424. PyrdxlP-dep_Trfase. IPR015422. PyrdxlP-dep_Trfase_dom1. IPR015421. PyrdxlP-dep_Trfase_major.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00266. Aminotran_5. 1 hit.
PIRSFⁱ	PIRSF000525. SerC. 1 hit.
SUPFAMⁱ	SSF53383. SSF53383. 1 hit.
TIGRFAMsⁱ	TIGR01364. serC_1. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00595. AA_TRANSFER_CLASS_5. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A7ZCF8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRKINFSAG PSAIPLDVLE HAKAEFTDYR GEGYSIMEIS HRSKTFEEIH 
        60         70         80         90        100
FGAMEKIRKL YGIGDEYEIL FLQGGAHLQF SMIPMNLYQG GRAEYANTGV 
       110        120        130        140        150
WTNKAIKEAK VLGANVDVVV SSEDENFSYI PEFKFSDDAD YAYICSNNTI 
       160        170        180        190        200
YGTQYKAMPK TKSPLVVDAS SDFFARPLDF SSIGLLYGGA QKNAGPSGVT 
       210        220        230        240        250
IVILRKDLVD RVSSQNVPMF LRYKTHVEAN SLYNTPPTFG IYLLNLTMQH 
       260        270        280        290        300
LLDLGGLAEV EKINAKKAST LYSIIDSSNG FYVGHAKKSS RSDMNVSFTI 
       310        320        330        340        350
PKDHALEPVF VEEALKEGML GLKGHRHLGG IRASIYNAVS QSDVDKLGEF 

MREFARKHG

Length:359

Mass (Da):39,849

Last modified:October 23, 2007 - v1

Checksum:ⁱ106C50A9BF840CB3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000792 Genomic DNA. Translation: EAT98927.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012001438.1. NC_009802.2.

Genome annotation databases

EnsemblBacteriaⁱ	EAT98927; EAT98927; CCC13826_1599.
KEGGⁱ	cco:CCC13826_1599.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A7ZCF8	UPI000CD928C3 U2EJI5 U2FDG1 G9QTU1 U2FPS7 U2GAY8 U2GQ38 I1DQV9 U2GGS2 A0A1Y5MM62 +58	Campylobacter concisus Campylobacter concisus UNSW3 Campylobacter concisus ATCC 51561 Campylobacter sp. 10_1_50 Campylobacter concisus UNSW2 Campylobacter concisus UNSW1 Campylobacter concisus UNSWCS Campylobacter concisus UNSWCD Campylobacter concisus ATCC 51562 Campylobacter	359	UniRef90_A7ZCF8	Cluster: Phosphoserine aminotransferase	69

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A7ZCF8	UPI000CD928C3 A0A1Y5MM62 UPI000CD969DA A0A1Y5MKP4 UPI000CD874E7 UPI000CD87233 UPI000CD7EA28 U2FDG1 UPI000CD80C48 UPI000CD872F3 +64	Campylobacter concisus Campylobacter concisus ATCC 51561 Campylobacter concisus UNSWCD Campylobacter Campylobacter concisus UNSWCS Campylobacter concisus UNSW2 Campylobacter concisus UNSW3 Campylobacter sp. 10_1_50 Campylobacter concisus UNSW1 Campylobacter concisus ATCC 51562 And more	359	UniRef50_A7ZCF8	Cluster: Phosphoserine aminotransferase	75

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000792 Genomic DNA. Translation: EAT98927.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012001438.1. NC_009802.2.

3D structure databases

ProteinModelPortalⁱ	A7ZCF8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	360104.CCC13826_1599.

STRINGⁱ

360104.CCC13826_1599.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	EAT98927; EAT98927; CCC13826_1599.
KEGGⁱ	cco:CCC13826_1599.

Phylogenomic databases

eggNOGⁱ	ENOG4107QM1. Bacteria. COG1932. LUCA.
HOGENOMⁱ	HOG000088965.
KEGG Orthology (KO) More...KOⁱ	K00831.
OMAⁱ	GAQKNMG.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01K1.

Enzyme and pathway databases

UniPathwayⁱ	UPA00135; UER00197. UPA00244; UER00311.

UniPathwayⁱ

UPA00135; UER00197.
UPA00244; UER00311.

Family and domain databases

Gene3Dⁱ	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
HAMAPⁱ	MF_00160. SerC_aminotrans_5. 1 hit.
InterProⁱ	View protein in InterPro IPR000192. Aminotrans_V_dom. IPR020578. Aminotrans_V_PyrdxlP_BS. IPR022278. Pser_aminoTfrase. IPR015424. PyrdxlP-dep_Trfase. IPR015422. PyrdxlP-dep_Trfase_dom1. IPR015421. PyrdxlP-dep_Trfase_major.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00266. Aminotran_5. 1 hit.
PIRSFⁱ	PIRSF000525. SerC. 1 hit.
SUPFAMⁱ	SSF53383. SSF53383. 1 hit.
TIGRFAMsⁱ	TIGR01364. serC_1. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00595. AA_TRANSFER_CLASS_5. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A7ZCF8_CAMC1
Accessionⁱ	A7ZCF8Primary (citable) accession number: A7ZCF8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 23, 2007
	Last sequence update:	October 23, 2007
	Last modified:	March 28, 2018
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A7ZCF8 (A7ZCF8_CAMC1)

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Phosphoserine aminotransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-serine biosynthesis

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pyridoxine 5'-phosphate biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: L-serine biosynthesis

Pathwayⁱ: pyridoxine 5'-phosphate biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ