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UniProtKB - A7ZCF8 (A7ZCF8_CAMC1)

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Protein

Phosphoserine aminotransferase

Gene

serC

Organism
Campylobacter concisus (strain 13826)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.UniRule annotationSAAS annotation

Catalytic activityi

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotationSAAS annotation
O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotationSAAS annotation

Pathwayi: L-serine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-3-phosphoglycerate dehydrogenase (serA)
  2. Phosphoserine aminotransferase (serC)
  3. no protein annotated in this organism
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Phosphoserine aminotransferase (serC)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42L-glutamateUniRule annotation1
Binding sitei101Pyridoxal phosphateUniRule annotation1
Binding sitei149Pyridoxal phosphateUniRule annotation1
Binding sitei168Pyridoxal phosphateUniRule annotation1
Binding sitei191Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionAminotransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Pyridoxine biosynthesisUniRule annotation, Serine biosynthesisUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00135; UER00197.
UPA00244; UER00311.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
Alternative name(s):
Phosphohydroxythreonine aminotransferaseUniRule annotation
Short name:
PSATUniRule annotation
Gene namesi
Name:serCUniRule annotationImported
ORF Names:CCC13826_1599Imported
OrganismiCampylobacter concisus (strain 13826)Imported
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter ›
Proteomesi
  • UP000001121 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi360104.CCC13826_1599.

Structurei

3D structure databases

ProteinModelPortaliA7ZCF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 347Aminotran_5InterPro annotationAdd BLAST342

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 235Pyridoxal phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107QM1. Bacteria.
COG1932. LUCA.
HOGENOMiHOG000088965.
KOiK00831.
OMAiGAQKNMG.
OrthoDBiPOG091H01K1.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5. 1 hit.
InterProiView protein in InterPro
IPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00266. Aminotran_5. 1 hit.
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiView protein in PROSITE
PS00595. AA_TRANSFER_CLASS_5. 1 hit.

Sequencei

Sequence statusi: Complete.

A7ZCF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKINFSAG PSAIPLDVLE HAKAEFTDYR GEGYSIMEIS HRSKTFEEIH 
        60         70         80         90        100
FGAMEKIRKL YGIGDEYEIL FLQGGAHLQF SMIPMNLYQG GRAEYANTGV 
       110        120        130        140        150
WTNKAIKEAK VLGANVDVVV SSEDENFSYI PEFKFSDDAD YAYICSNNTI 
       160        170        180        190        200
YGTQYKAMPK TKSPLVVDAS SDFFARPLDF SSIGLLYGGA QKNAGPSGVT 
       210        220        230        240        250
IVILRKDLVD RVSSQNVPMF LRYKTHVEAN SLYNTPPTFG IYLLNLTMQH 
       260        270        280        290        300
LLDLGGLAEV EKINAKKAST LYSIIDSSNG FYVGHAKKSS RSDMNVSFTI 
       310        320        330        340        350
PKDHALEPVF VEEALKEGML GLKGHRHLGG IRASIYNAVS QSDVDKLGEF 

MREFARKHG
Length:359
Mass (Da):39,849
Last modified:October 23, 2007 - v1
Checksum:i106C50A9BF840CB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000792 Genomic DNA. Translation: EAT98927.1.
RefSeqiWP_012001438.1. NC_009802.2.

Genome annotation databases

EnsemblBacteriaiEAT98927; EAT98927; CCC13826_1599.
KEGGicco:CCC13826_1599.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA7ZCF8_CAMC1
AccessioniPrimary (citable) accession number: A7ZCF8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 7, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported