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A7ZCF8 (A7ZCF8_CAMC1) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoserine aminotransferase HAMAP-Rule MF_00160 RuleBase RU004505
EC=2.6.1.52 HAMAP-Rule MF_00160 RuleBase RU004505
Alternative name(s):
Phosphohydroxythreonine aminotransferase HAMAP-Rule MF_00160
Gene names
Name:serC HAMAP-Rule MF_00160
Ordered Locus Names:Ccon26_05780 EMBL EAT98927.1
ORF Names:CCC13826_1599 EMBL EAT98927.1
OrganismCampylobacter concisus (strain 13826) [Complete proteome] [HAMAP] EMBL EAT98927.1
Taxonomic identifier360104 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter ›

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine By similarity. HAMAP-Rule MF_00160 SAAS SAAS020578

Catalytic activity

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate. HAMAP-Rule MF_00160 SAAS SAAS020578

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. HAMAP-Rule MF_00160 RuleBase RU004505 SAAS SAAS020578

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP-Rule MF_00160 SAAS SAAS020578

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. HAMAP-Rule MF_00160 RuleBase RU004505 SAAS SAAS020578

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. HAMAP-Rule MF_00160

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00160 SAAS SAAS020578

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00160.

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. HAMAP-Rule MF_00160

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region234 – 2352Pyridoxal phosphate binding By similarity HAMAP-Rule MF_00160

Sites

Binding site421L-glutamate By similarity HAMAP-Rule MF_00160
Binding site1011Pyridoxal phosphate By similarity HAMAP-Rule MF_00160
Binding site1491Pyridoxal phosphate By similarity HAMAP-Rule MF_00160
Binding site1681Pyridoxal phosphate By similarity HAMAP-Rule MF_00160
Binding site1911Pyridoxal phosphate By similarity HAMAP-Rule MF_00160

Amino acid modifications

Modified residue1921N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00160

Sequences

Sequence LengthMass (Da)Tools
A7ZCF8 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 106C50A9BF840CB3

FASTA35939,849
        10         20         30         40         50         60 
MSRKINFSAG PSAIPLDVLE HAKAEFTDYR GEGYSIMEIS HRSKTFEEIH FGAMEKIRKL 

        70         80         90        100        110        120 
YGIGDEYEIL FLQGGAHLQF SMIPMNLYQG GRAEYANTGV WTNKAIKEAK VLGANVDVVV 

       130        140        150        160        170        180 
SSEDENFSYI PEFKFSDDAD YAYICSNNTI YGTQYKAMPK TKSPLVVDAS SDFFARPLDF 

       190        200        210        220        230        240 
SSIGLLYGGA QKNAGPSGVT IVILRKDLVD RVSSQNVPMF LRYKTHVEAN SLYNTPPTFG 

       250        260        270        280        290        300 
IYLLNLTMQH LLDLGGLAEV EKINAKKAST LYSIIDSSNG FYVGHAKKSS RSDMNVSFTI 

       310        320        330        340        350 
PKDHALEPVF VEEALKEGML GLKGHRHLGG IRASIYNAVS QSDVDKLGEF MREFARKHG

« Hide

References

[1]"Genome sequence of Campylobacter concisus 13826 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13826.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000792 Genomic DNA. Translation: EAT98927.1.
RefSeqYP_001466466.1. NC_009802.1.

3D structure databases

ProteinModelPortalA7ZCF8.
ModBaseSearch...

Protein-protein interaction databases

STRING360104.CCC13826_1599.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEAT98927; EAT98927; CCC13826_1599.
GeneID5597228.
KEGGcco:CCC13826_1599.
PATRIC20027313. VBICamCon95352_0611.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1932.
HOGENOMHOG000088965.
KOK00831.
OMANNTIFGT.
OrthoDBEOG60CWP3.
ProtClustDBPRK05355.

Enzyme and pathway databases

BioCycCCON360104:GHAC-606-MONOMER.
UniPathwayUPA00135; UER00197.
UPA00244; UER00311.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_00160. SerC_aminotrans_5.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR21152:SF1. PTHR21152:SF1. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF000525. SerC. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01364. serC_1. 1 hit.
PROSITEPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7ZCF8_CAMC1
AccessionPrimary (citable) accession number: A7ZCF8
Entry history
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 13, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info