UniProtKB - A7ZCF8 (A7ZCF8_CAMC1)
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Protein
Phosphoserine aminotransferase
Gene
serC
Organism
Campylobacter concisus (strain 13826)
Status
Functioni
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.UniRule annotationSAAS annotation
Catalytic activityi
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotationSAAS annotation
O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotationSAAS annotation
: L-serine biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.UniRule annotationSAAS annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- D-3-phosphoglycerate dehydrogenase (serA)
- Phosphoserine aminotransferase (serC)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.
: pyridoxine 5'-phosphate biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- no protein annotated in this organism
- no protein annotated in this organism
- Phosphoserine aminotransferase (serC)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 42 | L-glutamateUniRule annotation | 1 | |
Binding sitei | 101 | Pyridoxal phosphateUniRule annotation | 1 | |
Binding sitei | 149 | Pyridoxal phosphateUniRule annotation | 1 | |
Binding sitei | 168 | Pyridoxal phosphateUniRule annotation | 1 | |
Binding sitei | 191 | Pyridoxal phosphateUniRule annotation | 1 |
GO - Molecular functioni
- O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-UniRule
- pyridoxal phosphate binding Source: UniProtKB-UniRule
GO - Biological processi
- L-serine biosynthetic process Source: UniProtKB-UniRule
- pyridoxine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | AminotransferaseUniRule annotationSAAS annotationImported, Transferase |
Biological process | Amino-acid biosynthesis, Pyridoxine biosynthesisUniRule annotation, Serine biosynthesisUniRule annotationSAAS annotation |
Ligand | Pyridoxal phosphateUniRule annotationSAAS annotation |
Enzyme and pathway databases
UniPathwayi | UPA00135; UER00197. UPA00244; UER00311. |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)Alternative name(s): Phosphohydroxythreonine aminotransferaseUniRule annotation Short name: PSATUniRule annotation |
Gene namesi | Name:serCUniRule annotationImported ORF Names:CCC13826_1599Imported |
Organismi | Campylobacter concisus (strain 13826)Imported |
Taxonomic identifieri | 360104 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 192 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Interactioni
Subunit structurei
Homodimer.UniRule annotationSAAS annotation
Protein-protein interaction databases
STRINGi | 360104.CCC13826_1599. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 347 | Aminotran_5InterPro annotationAdd BLAST | 342 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 234 – 235 | Pyridoxal phosphate bindingUniRule annotation | 2 |
Sequence similaritiesi
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.SAAS annotation
Phylogenomic databases
eggNOGi | ENOG4107QM1. Bacteria. COG1932. LUCA. |
HOGENOMi | HOG000088965. |
KOi | K00831. |
OMAi | GAQKNMG. |
OrthoDBi | POG091H01K1. |
Family and domain databases
Gene3Di | 3.40.640.10. 1 hit. 3.90.1150.10. 1 hit. |
HAMAPi | MF_00160. SerC_aminotrans_5. 1 hit. |
InterProi | View protein in InterPro IPR000192. Aminotrans_V_dom. IPR020578. Aminotrans_V_PyrdxlP_BS. IPR022278. Pser_aminoTfrase. IPR015424. PyrdxlP-dep_Trfase. IPR015422. PyrdxlP-dep_Trfase_dom1. IPR015421. PyrdxlP-dep_Trfase_major. |
Pfami | View protein in Pfam PF00266. Aminotran_5. 1 hit. |
PIRSFi | PIRSF000525. SerC. 1 hit. |
SUPFAMi | SSF53383. SSF53383. 1 hit. |
TIGRFAMsi | TIGR01364. serC_1. 1 hit. |
PROSITEi | View protein in PROSITE PS00595. AA_TRANSFER_CLASS_5. 1 hit. |
i Sequence
Sequence statusi: Complete.
A7ZCF8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRKINFSAG PSAIPLDVLE HAKAEFTDYR GEGYSIMEIS HRSKTFEEIH
60 70 80 90 100
FGAMEKIRKL YGIGDEYEIL FLQGGAHLQF SMIPMNLYQG GRAEYANTGV
110 120 130 140 150
WTNKAIKEAK VLGANVDVVV SSEDENFSYI PEFKFSDDAD YAYICSNNTI
160 170 180 190 200
YGTQYKAMPK TKSPLVVDAS SDFFARPLDF SSIGLLYGGA QKNAGPSGVT
210 220 230 240 250
IVILRKDLVD RVSSQNVPMF LRYKTHVEAN SLYNTPPTFG IYLLNLTMQH
260 270 280 290 300
LLDLGGLAEV EKINAKKAST LYSIIDSSNG FYVGHAKKSS RSDMNVSFTI
310 320 330 340 350
PKDHALEPVF VEEALKEGML GLKGHRHLGG IRASIYNAVS QSDVDKLGEF
MREFARKHG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000792 Genomic DNA. Translation: EAT98927.1. |
RefSeqi | WP_012001438.1. NC_009802.2. |
Genome annotation databases
EnsemblBacteriai | EAT98927; EAT98927; CCC13826_1599. |
KEGGi | cco:CCC13826_1599. |
Similar proteinsi
Entry informationi
Entry namei | A7ZCF8_CAMC1 | |
Accessioni | A7ZCF8Primary (citable) accession number: A7ZCF8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 23, 2007 |
Last sequence update: | October 23, 2007 | |
Last modified: | March 28, 2018 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |
Miscellaneousi
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation