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Protein

Phosphoserine aminotransferase

Gene

serC

Organism
Campylobacter concisus (strain 13826)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.UniRule annotationSAAS annotation

Catalytic activityi

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotationSAAS annotation
O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • pyridoxal 5'-phosphateUniRule annotation
  • pyridoxal 5'-phosphateUniRule annotationSAAS annotationNote: Binds 1 pyridoxal phosphate per subunit.UniRule annotationSAAS annotation
  • pyridoxal 5'-phosphateNote: Binds 1 pyridoxal phosphate per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421L-glutamateUniRule annotation
Binding sitei101 – 1011Pyridoxal phosphateUniRule annotation
Binding sitei149 – 1491Pyridoxal phosphateUniRule annotation
Binding sitei168 – 1681Pyridoxal phosphateUniRule annotation
Binding sitei191 – 1911Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-serine biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Pyridoxine biosynthesisUniRule annotation, Serine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCCON360104:GHAC-606-MONOMER.
UniPathwayiUPA00135; UER00197.
UPA00244; UER00311.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
Alternative name(s):
Phosphohydroxythreonine aminotransferaseUniRule annotation
Gene namesi
Name:serCUniRule annotationImported
ORF Names:CCC13826_1599Imported
OrganismiCampylobacter concisus (strain 13826)Imported
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei192 – 1921N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi360104.CCC13826_1599.

Structurei

3D structure databases

ProteinModelPortaliA7ZCF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni234 – 2352Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1932.
HOGENOMiHOG000088965.
KOiK00831.
OMAiNNTIFGT.
OrthoDBiEOG60CWP3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5.
InterProiIPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZCF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKINFSAG PSAIPLDVLE HAKAEFTDYR GEGYSIMEIS HRSKTFEEIH
60 70 80 90 100
FGAMEKIRKL YGIGDEYEIL FLQGGAHLQF SMIPMNLYQG GRAEYANTGV
110 120 130 140 150
WTNKAIKEAK VLGANVDVVV SSEDENFSYI PEFKFSDDAD YAYICSNNTI
160 170 180 190 200
YGTQYKAMPK TKSPLVVDAS SDFFARPLDF SSIGLLYGGA QKNAGPSGVT
210 220 230 240 250
IVILRKDLVD RVSSQNVPMF LRYKTHVEAN SLYNTPPTFG IYLLNLTMQH
260 270 280 290 300
LLDLGGLAEV EKINAKKAST LYSIIDSSNG FYVGHAKKSS RSDMNVSFTI
310 320 330 340 350
PKDHALEPVF VEEALKEGML GLKGHRHLGG IRASIYNAVS QSDVDKLGEF

MREFARKHG
Length:359
Mass (Da):39,849
Last modified:October 23, 2007 - v1
Checksum:i106C50A9BF840CB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000792 Genomic DNA. Translation: EAT98927.1.
RefSeqiWP_012001438.1. NC_009802.1.
YP_001466466.1. NC_009802.1.

Genome annotation databases

EnsemblBacteriaiEAT98927; EAT98927; CCC13826_1599.
GeneIDi5597228.
KEGGicco:CCC13826_1599.
PATRICi20027313. VBICamCon95352_0611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000792 Genomic DNA. Translation: EAT98927.1.
RefSeqiWP_012001438.1. NC_009802.1.
YP_001466466.1. NC_009802.1.

3D structure databases

ProteinModelPortaliA7ZCF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360104.CCC13826_1599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEAT98927; EAT98927; CCC13826_1599.
GeneIDi5597228.
KEGGicco:CCC13826_1599.
PATRICi20027313. VBICamCon95352_0611.

Phylogenomic databases

eggNOGiCOG1932.
HOGENOMiHOG000088965.
KOiK00831.
OMAiNNTIFGT.
OrthoDBiEOG60CWP3.

Enzyme and pathway databases

UniPathwayiUPA00135; UER00197.
UPA00244; UER00311.
BioCyciCCON360104:GHAC-606-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5.
InterProiIPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826Imported.

Entry informationi

Entry nameiA7ZCF8_CAMC1
AccessioniPrimary (citable) accession number: A7ZCF8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: March 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.