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A7ZCF7 (A7ZCF7_CAMC1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315 EMBL EAT98926.1
Ordered Locus Names:Ccon26_05730
ORF Names:CCC13826_1594 EMBL EAT98926.1
OrganismCampylobacter concisus (strain 13826) [Complete proteome] [HAMAP]
Taxonomic identifier360104 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS001017

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS001017

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS001017

Subunit structure

Homodimer By similarity. HAMAP MF_00315

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
A7ZCF7 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 29C650BE4A207FE3

FASTA60867,370
        10         20         30         40         50         60 
MNKDVKSLNV DELNALCHDI RDKILATVSK NGGHLSSNIG AVEIIVAMHK IFDVTKDPFI 

        70         80         90        100        110        120 
FDVSHQSYAH KLLTGRWDKF DTLRKFNGIS GYTKPSESKF DYFVAGHSST SISLAVGAAK 

       130        140        150        160        170        180 
AIKLKNEERL PVAVIGDGSL SGGMAYEALN ELGDRKYPCV IILNDNEMSI SKPIGALSKY 

       190        200        210        220        230        240 
LSQMMAGQFY QKFKGRVERF LSYMPDSAAY MARRMEEGIR LITPGMFFEE LGLEYIGPVD 

       250        260        270        280        290        300 
GHDLLALLST FKTAKNMKKP VIVHVQTLKG KGYEFAEGYY ENWHGVGPFD LKSGEFIKRQ 

       310        320        330        340        350        360 
SNKSATAIFS EQLLKMAREH SDIVGVTAAM PTGTGMDALI HEFPDRFWDV AIAEQHAVTS 

       370        380        390        400        410        420 
MSAMAKEGFK PFVAIYSTFM QRAYDQVIHD ASILNLNITF AMDRAGIVGE DGETHQGAFD 

       430        440        450        460        470        480 
ISFLNAVPNM VLFAPRCEES MKNVMEFAYS YKGVSAFRYP RGAFILRDEF KAKPLEFGKG 

       490        500        510        520        530        540 
EILADAKSDI AFLGYGNGVG RANLVRNLLA GKLEAILVDL VFVKPLDREL LLDLAKRTKK 

       550        560        570        580        590        600 
WYIFSDSAKK GGVGEIVSAF LQENGISNVS VVSFEYDDKF IQHGSTAEVE KSLGISAEQI 


AQFLLENN

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References

[1]"Genome sequence of Campylobacter concisus 13826 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000792 Genomic DNA. Translation: EAT98926.1.
RefSeqYP_001466465.1. NC_009802.1.

3D structure databases

ProteinModelPortalA7ZCF7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7ZCF7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5596165.
GenomeReviewsGene locus Ccon26_05730 in contig CP000792_GR.
KEGGcco:CCC13826_1594.
PATRIC20027303. VBICamCon95352_0606.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMAYPRGAFI.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR001017. DH_E1.
IPR005477. Dxylulose-5-P_synthase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7ZCF7_CAMC1
AccessionPrimary (citable) accession number: A7ZCF7
Entry history
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info