A7ZCF3 (HIS8_CAMC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	Ccon26_05690
ORF Names:	CCC13826_1590

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP]

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_1000072942
Amino acid modifications
	Modified residue	227	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7ZCF3 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 1AEF239E1FB25ABF	FASTA	365	41,317
	10 20 30 40 50 60 MKFNDFLDDL VNYEAGKPIE LVVREFGIDA KDVIKLASNE NPFGTSKRVE EALKEVAKNA 70 80 90 100 110 120 HLYPDDSYFE LKEGLAKKFG VTSKKLIIGS GSDQIIEFAL HAKANRQSGV LMAGVTFAMY 130 140 150 160 170 180 EIYAKQTGAK IYRTKSVEHN LSEFLEIYNA HKDEISVIFL CLPNNPLGEC IDADEVYKFI 190 200 210 220 230 240 KNIDENTLVV LDCAYNEFAK FKDSKKEIKP SEVVKFKNAI YLGTFSKAYA LGGMRVGYGV 250 260 270 280 290 300 ANEEIIGALS KLRAPFNITT PSLRAAIVAL GDDEFVQKTM QNNFEQMKRY EDFAEQNGIE 310 320 330 340 350 360 FIPSYTNFIT FKFNEPKSSQ ICEKMLKKGI ILRDLKSYAL NAVRITIGQA WQNDRVFEEL EQILK

References

[1]

"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13826.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000792 Genomic DNA. Translation: EAT99008.1.
RefSeq	YP_001466461.1. NC_009802.1.
3D structure databases
ProteinModelPortal	A7ZCF3.
ModBase	Search...
Protein-protein interaction databases
STRING	A7ZCF3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5595749.
GenomeReviews	Gene locus Ccon26_05690 in contig CP000792_GR.
KEGG	cco:CCC13826_1590.
PATRIC	20027295. VBICamCon95352_0602.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	YEYAEAE.
ProtClustDB	PRK02731.
Enzyme and pathway databases
BioCyc	CCON360104:CCC13826_1590-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_CAMC1

Accession

Primary (citable) accession number: A7ZCF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program