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A7ZC69

- IF2_CAMC1

UniProt

A7ZC69 - IF2_CAMC1

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi393 – 4008GTPUniRule annotation
Nucleotide bindingi439 – 4435GTPUniRule annotation
Nucleotide bindingi493 – 4964GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCON360104:GHAC-504-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Ccon26_04760
ORF Names:CCC13826_1495
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 885885Translation initiation factor IF-2PRO_1000008219Add
BLAST

Proteomic databases

PRIDEiA7ZC69.

Interactioni

Protein-protein interaction databases

STRINGi360104.CCC13826_1495.

Structurei

3D structure databases

ProteinModelPortaliA7ZC69.
SMRiA7ZC69. Positions 788-876.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini384 – 553170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni393 – 4008G1By similarity
Regioni418 – 4225G2By similarity
Regioni439 – 4424G3By similarity
Regioni493 – 4964G4By similarity
Regioni529 – 5313G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiEHEFIPV.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZC69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNVRISEIA NELGYPSKEI VEKAQELGLK VKTHSNAVSL EEAEAIYEYV
60 70 80 90 100
QTGVIPDKFK KKKSEPKAKK EPKKETEKEP AKKEEKPKTE PKKAATKAEP
110 120 130 140 150
KPEKAKAEPK KEAQISEEKP KTEPKKEEPV KVEQKPAEAP KPKESLADVT
160 170 180 190 200
QKRRGLVIVK KKKDYEAPAP IKEEKKAEAA VTNISDFKSM FSASDENLAR
210 220 230 240 250
KKKKEKKVTV VSKKDSAEKM DLLGGSDFGD IVLEDEDVVV LPDFSFKTPA
260 270 280 290 300
PTPMQRTKQP NAMKTTVNNT INSFGEGGIQ RRARKKHKKP ENKQNSEAVT
310 320 330 340 350
SINIPKEIRV YEFAEKLNKQ PSEVIGKLFM LGMMTTKNDF LDEDAIEILA
360 370 380 390 400
DEFNVEVNII DDQKEFDYVA AYEEEIKDDE NLQPRAPVIT IMGHVDHGKT
410 420 430 440 450
SLLDYIRKSR VAAGEAGGIT QHVGAYMVNK NGRNITFIDT PGHEAFTAMR
460 470 480 490 500
ARGAGVTDIV IIVVAADDGV KPQTKEAVSH AKAAGVPIII AINKMDKESA
510 520 530 540 550
NPDLVKTGLA ELDIMPTEWG GKYEFVPISA KTGMGIDDLL EIVLLQADLL
560 570 580 590 600
ELKANPKANA KATVIESSLQ KGRGPVATII VENGTLHVGD TVVAGVAYGK
610 620 630 640 650
IRSLLDDQGR SLREIKPGEC GVIVGLSEIA EAGETLIGVK TDKEAREYAQ
660 670 680 690 700
KKAEYIRQKE LSKSTKVSID ELSAKIAEGE LKTLPVIIKA DVGGSLEALK
710 720 730 740 750
ASLEKLANDE IRVNVIHSGV GGITQSDVAL ASASNDCIIL GFNIRPTGEI
760 770 780 790 800
KEKAKESGVE IKTYNVIYNL IDDVKAILGG LMSPIIREEQ LGQAQVRQVI
810 820 830 840 850
HVPKVGTIAG CIVTEGTINR GAKIRLIREG VVVYEGLVSS LKRFKDDVKE
860 870 880
VAKGYECGVG IENFNDIREN DYIESFKEVK EKATL
Length:885
Mass (Da):96,941
Last modified:October 23, 2007 - v1
Checksum:i8A1AADE7F6978261
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT99040.1.
RefSeqiYP_001466377.1. NC_009802.1.

Genome annotation databases

EnsemblBacteriaiEAT99040; EAT99040; CCC13826_1495.
GeneIDi5597328.
KEGGicco:CCC13826_1495.
PATRICi20027103. VBICamCon95352_0507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: EAT99040.1 .
RefSeqi YP_001466377.1. NC_009802.1.

3D structure databases

ProteinModelPortali A7ZC69.
SMRi A7ZC69. Positions 788-876.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360104.CCC13826_1495.

Proteomic databases

PRIDEi A7ZC69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT99040 ; EAT99040 ; CCC13826_1495 .
GeneIDi 5597328.
KEGGi cco:CCC13826_1495.
PATRICi 20027103. VBICamCon95352_0507.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi EHEFIPV.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci CCON360104:GHAC-504-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826.

Entry informationi

Entry nameiIF2_CAMC1
AccessioniPrimary (citable) accession number: A7ZC69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3