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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi393 – 400GTPUniRule annotation8
Nucleotide bindingi439 – 443GTPUniRule annotation5
Nucleotide bindingi493 – 496GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Ccon26_04760
ORF Names:CCC13826_1495
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000001121 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000082191 – 885Translation initiation factor IF-2Add BLAST885

Proteomic databases

PRIDEiA7ZC69.

Interactioni

Protein-protein interaction databases

STRINGi360104.CCC13826_1495.

Structurei

3D structure databases

ProteinModelPortaliA7ZC69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini384 – 553tr-type GAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni393 – 400G1By similarity8
Regioni418 – 422G2By similarity5
Regioni439 – 442G3By similarity4
Regioni493 – 496G4By similarity4
Regioni529 – 531G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076906.
KOiK02519.
OMAiIKRNDEA.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZC69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVRISEIA NELGYPSKEI VEKAQELGLK VKTHSNAVSL EEAEAIYEYV
60 70 80 90 100
QTGVIPDKFK KKKSEPKAKK EPKKETEKEP AKKEEKPKTE PKKAATKAEP
110 120 130 140 150
KPEKAKAEPK KEAQISEEKP KTEPKKEEPV KVEQKPAEAP KPKESLADVT
160 170 180 190 200
QKRRGLVIVK KKKDYEAPAP IKEEKKAEAA VTNISDFKSM FSASDENLAR
210 220 230 240 250
KKKKEKKVTV VSKKDSAEKM DLLGGSDFGD IVLEDEDVVV LPDFSFKTPA
260 270 280 290 300
PTPMQRTKQP NAMKTTVNNT INSFGEGGIQ RRARKKHKKP ENKQNSEAVT
310 320 330 340 350
SINIPKEIRV YEFAEKLNKQ PSEVIGKLFM LGMMTTKNDF LDEDAIEILA
360 370 380 390 400
DEFNVEVNII DDQKEFDYVA AYEEEIKDDE NLQPRAPVIT IMGHVDHGKT
410 420 430 440 450
SLLDYIRKSR VAAGEAGGIT QHVGAYMVNK NGRNITFIDT PGHEAFTAMR
460 470 480 490 500
ARGAGVTDIV IIVVAADDGV KPQTKEAVSH AKAAGVPIII AINKMDKESA
510 520 530 540 550
NPDLVKTGLA ELDIMPTEWG GKYEFVPISA KTGMGIDDLL EIVLLQADLL
560 570 580 590 600
ELKANPKANA KATVIESSLQ KGRGPVATII VENGTLHVGD TVVAGVAYGK
610 620 630 640 650
IRSLLDDQGR SLREIKPGEC GVIVGLSEIA EAGETLIGVK TDKEAREYAQ
660 670 680 690 700
KKAEYIRQKE LSKSTKVSID ELSAKIAEGE LKTLPVIIKA DVGGSLEALK
710 720 730 740 750
ASLEKLANDE IRVNVIHSGV GGITQSDVAL ASASNDCIIL GFNIRPTGEI
760 770 780 790 800
KEKAKESGVE IKTYNVIYNL IDDVKAILGG LMSPIIREEQ LGQAQVRQVI
810 820 830 840 850
HVPKVGTIAG CIVTEGTINR GAKIRLIREG VVVYEGLVSS LKRFKDDVKE
860 870 880
VAKGYECGVG IENFNDIREN DYIESFKEVK EKATL
Length:885
Mass (Da):96,941
Last modified:October 23, 2007 - v1
Checksum:i8A1AADE7F6978261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000792 Genomic DNA. Translation: EAT99040.1.
RefSeqiWP_012001357.1. NC_009802.1.

Genome annotation databases

EnsemblBacteriaiEAT99040; EAT99040; CCC13826_1495.
KEGGicco:CCC13826_1495.
PATRICi20027103. VBICamCon95352_0507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000792 Genomic DNA. Translation: EAT99040.1.
RefSeqiWP_012001357.1. NC_009802.1.

3D structure databases

ProteinModelPortaliA7ZC69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360104.CCC13826_1495.

Proteomic databases

PRIDEiA7ZC69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEAT99040; EAT99040; CCC13826_1495.
KEGGicco:CCC13826_1495.
PATRICi20027103. VBICamCon95352_0507.

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076906.
KOiK02519.
OMAiIKRNDEA.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_CAMC1
AccessioniPrimary (citable) accession number: A7ZC69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.