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A7ZC69

- IF2_CAMC1

UniProt

A7ZC69 - IF2_CAMC1

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi393 – 4008GTPUniRule annotation
    Nucleotide bindingi439 – 4435GTPUniRule annotation
    Nucleotide bindingi493 – 4964GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCON360104:GHAC-504-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:Ccon26_04760
    ORF Names:CCC13826_1495
    OrganismiCampylobacter concisus (strain 13826)
    Taxonomic identifieri360104 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000001121: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 885885Translation initiation factor IF-2PRO_1000008219Add
    BLAST

    Proteomic databases

    PRIDEiA7ZC69.

    Interactioni

    Protein-protein interaction databases

    STRINGi360104.CCC13826_1495.

    Structurei

    3D structure databases

    ProteinModelPortaliA7ZC69.
    SMRiA7ZC69. Positions 788-876.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini384 – 553170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni393 – 4008G1By similarity
    Regioni418 – 4225G2By similarity
    Regioni439 – 4424G3By similarity
    Regioni493 – 4964G4By similarity
    Regioni529 – 5313G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiEHEFIPV.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7ZC69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNVRISEIA NELGYPSKEI VEKAQELGLK VKTHSNAVSL EEAEAIYEYV    50
    QTGVIPDKFK KKKSEPKAKK EPKKETEKEP AKKEEKPKTE PKKAATKAEP 100
    KPEKAKAEPK KEAQISEEKP KTEPKKEEPV KVEQKPAEAP KPKESLADVT 150
    QKRRGLVIVK KKKDYEAPAP IKEEKKAEAA VTNISDFKSM FSASDENLAR 200
    KKKKEKKVTV VSKKDSAEKM DLLGGSDFGD IVLEDEDVVV LPDFSFKTPA 250
    PTPMQRTKQP NAMKTTVNNT INSFGEGGIQ RRARKKHKKP ENKQNSEAVT 300
    SINIPKEIRV YEFAEKLNKQ PSEVIGKLFM LGMMTTKNDF LDEDAIEILA 350
    DEFNVEVNII DDQKEFDYVA AYEEEIKDDE NLQPRAPVIT IMGHVDHGKT 400
    SLLDYIRKSR VAAGEAGGIT QHVGAYMVNK NGRNITFIDT PGHEAFTAMR 450
    ARGAGVTDIV IIVVAADDGV KPQTKEAVSH AKAAGVPIII AINKMDKESA 500
    NPDLVKTGLA ELDIMPTEWG GKYEFVPISA KTGMGIDDLL EIVLLQADLL 550
    ELKANPKANA KATVIESSLQ KGRGPVATII VENGTLHVGD TVVAGVAYGK 600
    IRSLLDDQGR SLREIKPGEC GVIVGLSEIA EAGETLIGVK TDKEAREYAQ 650
    KKAEYIRQKE LSKSTKVSID ELSAKIAEGE LKTLPVIIKA DVGGSLEALK 700
    ASLEKLANDE IRVNVIHSGV GGITQSDVAL ASASNDCIIL GFNIRPTGEI 750
    KEKAKESGVE IKTYNVIYNL IDDVKAILGG LMSPIIREEQ LGQAQVRQVI 800
    HVPKVGTIAG CIVTEGTINR GAKIRLIREG VVVYEGLVSS LKRFKDDVKE 850
    VAKGYECGVG IENFNDIREN DYIESFKEVK EKATL 885
    Length:885
    Mass (Da):96,941
    Last modified:October 23, 2007 - v1
    Checksum:i8A1AADE7F6978261
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000792 Genomic DNA. Translation: EAT99040.1.
    RefSeqiYP_001466377.1. NC_009802.1.

    Genome annotation databases

    EnsemblBacteriaiEAT99040; EAT99040; CCC13826_1495.
    GeneIDi5597328.
    KEGGicco:CCC13826_1495.
    PATRICi20027103. VBICamCon95352_0507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000792 Genomic DNA. Translation: EAT99040.1 .
    RefSeqi YP_001466377.1. NC_009802.1.

    3D structure databases

    ProteinModelPortali A7ZC69.
    SMRi A7ZC69. Positions 788-876.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360104.CCC13826_1495.

    Proteomic databases

    PRIDEi A7ZC69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EAT99040 ; EAT99040 ; CCC13826_1495 .
    GeneIDi 5597328.
    KEGGi cco:CCC13826_1495.
    PATRICi 20027103. VBICamCon95352_0507.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi EHEFIPV.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci CCON360104:GHAC-504-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
      Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13826.

    Entry informationi

    Entry nameiIF2_CAMC1
    AccessioniPrimary (citable) accession number: A7ZC69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3