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A7ZC69 (IF2_CAMC1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:Ccon26_04760
ORF Names:CCC13826_1495
OrganismCampylobacter concisus (strain 13826) [Complete proteome] [HAMAP]
Taxonomic identifier360104 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length885 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 885885Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000008219

Regions

Nucleotide binding393 – 4008GTP By similarity
Nucleotide binding439 – 4435GTP By similarity
Nucleotide binding493 – 4964GTP By similarity
Region387 – 535149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
A7ZC69 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 8A1AADE7F6978261

FASTA88596,941
        10         20         30         40         50         60 
MSNVRISEIA NELGYPSKEI VEKAQELGLK VKTHSNAVSL EEAEAIYEYV QTGVIPDKFK 

        70         80         90        100        110        120 
KKKSEPKAKK EPKKETEKEP AKKEEKPKTE PKKAATKAEP KPEKAKAEPK KEAQISEEKP 

       130        140        150        160        170        180 
KTEPKKEEPV KVEQKPAEAP KPKESLADVT QKRRGLVIVK KKKDYEAPAP IKEEKKAEAA 

       190        200        210        220        230        240 
VTNISDFKSM FSASDENLAR KKKKEKKVTV VSKKDSAEKM DLLGGSDFGD IVLEDEDVVV 

       250        260        270        280        290        300 
LPDFSFKTPA PTPMQRTKQP NAMKTTVNNT INSFGEGGIQ RRARKKHKKP ENKQNSEAVT 

       310        320        330        340        350        360 
SINIPKEIRV YEFAEKLNKQ PSEVIGKLFM LGMMTTKNDF LDEDAIEILA DEFNVEVNII 

       370        380        390        400        410        420 
DDQKEFDYVA AYEEEIKDDE NLQPRAPVIT IMGHVDHGKT SLLDYIRKSR VAAGEAGGIT 

       430        440        450        460        470        480 
QHVGAYMVNK NGRNITFIDT PGHEAFTAMR ARGAGVTDIV IIVVAADDGV KPQTKEAVSH 

       490        500        510        520        530        540 
AKAAGVPIII AINKMDKESA NPDLVKTGLA ELDIMPTEWG GKYEFVPISA KTGMGIDDLL 

       550        560        570        580        590        600 
EIVLLQADLL ELKANPKANA KATVIESSLQ KGRGPVATII VENGTLHVGD TVVAGVAYGK 

       610        620        630        640        650        660 
IRSLLDDQGR SLREIKPGEC GVIVGLSEIA EAGETLIGVK TDKEAREYAQ KKAEYIRQKE 

       670        680        690        700        710        720 
LSKSTKVSID ELSAKIAEGE LKTLPVIIKA DVGGSLEALK ASLEKLANDE IRVNVIHSGV 

       730        740        750        760        770        780 
GGITQSDVAL ASASNDCIIL GFNIRPTGEI KEKAKESGVE IKTYNVIYNL IDDVKAILGG 

       790        800        810        820        830        840 
LMSPIIREEQ LGQAQVRQVI HVPKVGTIAG CIVTEGTINR GAKIRLIREG VVVYEGLVSS 

       850        860        870        880 
LKRFKDDVKE VAKGYECGVG IENFNDIREN DYIESFKEVK EKATL 

« Hide

References

[1]"Genome sequence of Campylobacter concisus 13826 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13826.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000792 Genomic DNA. Translation: EAT99040.1.
RefSeqYP_001466377.1. NC_009802.1.

3D structure databases

ProteinModelPortalA7ZC69.
SMRA7ZC69. Positions 788-876.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360104.CCC13826_1495.

Proteomic databases

PRIDEA7ZC69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEAT99040; EAT99040; CCC13826_1495.
GeneID5597328.
KEGGcco:CCC13826_1495.
PATRIC20027103. VBICamCon95352_0507.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMAHDERGHE.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycCCON360104:GHAC-504-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_CAMC1
AccessionPrimary (citable) accession number: A7ZC69
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries