A7ZBP3 (NTPA_CAMC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase
EC=3.6.1.19

Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase

Gene names

Ordered Locus Names:	Ccon26_02910
ORF Names:	CCC13826_0746

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP]

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Non-canonical purine NTP pyrophosphatase HAMAP MF_01405		PRO_1000073506
Regions
	Region	7 – 12	6	Substrate binding By similarity
	Region	74 – 75	2	Substrate binding By similarity
Sites
	Metal binding	74	1	Magnesium or manganese By similarity
	Binding site	168	1	Substrate By similarity
	Binding site	188	1	Substrate By similarity
	Binding site	194	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7ZBP3 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 4D95970248E8B923	FASTA	213	23,369
	10 20 30 40 50 60 MKIVLATSNL DKVKEIKEFL KGYEIYALSE VVKPFEIVED GSTFQANALI KSRAVFAKLK 70 80 90 100 110 120 ELGLEDEFVS LSDDSGISVD ALGGEPGIYS ARYFDLDENG KVCGKNANDA NNRAKLISKL 130 140 150 160 170 180 KALNLKSSPA HYTACIAISS KFGDYTAHGF MYGEAIDEER GTNGFGYDAL FIPNGFNKTL 190 200 210 GELDNETKLK ISHRSKGLEL ANFVLKSLKK NFS

References

[1]

"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13826.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000792 Genomic DNA. Translation: EAT98805.1.
RefSeq	YP_001466201.1. NC_009802.1.
3D structure databases
ProteinModelPortal	A7ZBP3.
ModBase	Search...
Protein-protein interaction databases
STRING	A7ZBP3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5596753.
GenomeReviews	Gene locus Ccon26_02910 in contig CP000792_GR.
KEGG	cco:CCC13826_0746.
PATRIC	20026729. VBICamCon95352_0321.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0127.
HOGENOM	HBG697237.
OMA	GVYTADW.
ProtClustDB	PRK00120.
Enzyme and pathway databases
BioCyc	CCON360104:CCC13826_0746-MONOMER.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_CAMC1

Accession

Primary (citable) accession number: A7ZBP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program