Reviewed, UniProtKB/Swiss-Prot A7ZBP3 (NTPA_CAMC1)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:	Ccon26_02910
ORF Names:	CCC13826_0746

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP]

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Nucleoside-triphosphatase		PRO_1000073506

Sequences

	Sequence		Length	Mass (Da)
	A7ZBP3-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 4D95970248E8B923	FASTA	213	23,369
	10 20 30 40 50 60 MKIVLATSNL DKVKEIKEFL KGYEIYALSE VVKPFEIVED GSTFQANALI KSRAVFAKLK 70 80 90 100 110 120 ELGLEDEFVS LSDDSGISVD ALGGEPGIYS ARYFDLDENG KVCGKNANDA NNRAKLISKL 130 140 150 160 170 180 KALNLKSSPA HYTACIAISS KFGDYTAHGF MYGEAIDEER GTNGFGYDAL FIPNGFNKTL 190 200 210 GELDNETKLK ISHRSKGLEL ANFVLKSLKK NFS

References

[1]	"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000792 Genomic DNA. Translation: EAT98805.1.
RefSeq	YP_001466201.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5596753.
GenomeReviews	Gene locus Ccon26_02910 in contig CP000792_GR.
KEGG	cco:CCC13826_0746.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_CAMC1

Accession

Primary (citable) accession number: A7ZBP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 23, 2007
Last modified:	September 2, 2008
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)