A7ZAZ4 (UNG_CAMC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uracil-DNA glycosylase
Short name=UDG
EC=3.2.2.27

Gene names

Name:	ung
Ordered Locus Names:	Ccon26_00300
ORF Names:	CCC13826_1822

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP]

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter concisus

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity. HAMAP-Rule MF_00148
Catalytic activity	Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil. HAMAP-Rule MF_00148
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uracil-DNA glycosylase family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	base-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	uracil DNA N-glycosylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Uracil-DNA glycosylase HAMAP-Rule MF_00148		PRO_1000009871
Sites
	Active site	70	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7ZAZ4 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: F63B9896F41924D2	FASTA	230	25,240
	10 20 30 40 50 60 MQINLNDVKI EPSWKEVLKD EFLSENFARI KENFLKAKSA GVVYPPSGLI FNAFNLTPFH 70 80 90 100 110 120 DVKVVILGQD PYHGANQAMG LSFSVPSGVR VPPSLVNIYK EIYADLGIKE PNSGDLTKWA 130 140 150 160 170 180 KQGVLLLNST LSVSAGAANS HASFGWQGFT DAVIRKISEN LQNVVFMLWG NPAKAKAPLI 190 200 210 220 230 DASKHLILEA AHPSPLARGA FFGCRHFSKA NIYLAKHGKT PIEWDLNTKI

References

[1]

"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13826.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000792 Genomic DNA. Translation: EAT99078.1.
RefSeq	YP_001465952.1. NC_009802.1.
3D structure databases
ProteinModelPortal	A7ZAZ4.
ModBase	Search...
Protein-protein interaction databases
STRING	360104.CCC13826_1822.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EAT99078; EAT99078; CCC13826_1822.
GeneID	5597314.
KEGG	cco:CCC13826_1822.
PATRIC	20026203. VBICamCon95352_0070.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0692.
HOGENOM	HOG000229528.
KO	K03648.
OMA	FRKINDF.
ProtClustDB	PRK05254.
Enzyme and pathway databases
BioCyc	CCON360104:GHAC-91-MONOMER.
Family and domain databases
Gene3D	3.40.470.10. 1 hit.
HAMAP	MF_00148. UDG.
InterPro	IPR018085. Ura-DNA_Glyclase_AS. IPR002043. Ura_DNA_glycsylse. IPR005122. Uracil-DNA_glycosylase-like. [Graphical view]
PANTHER	PTHR11264. PTHR11264. 1 hit.
Pfam	PF03167. UDG. 1 hit. [Graphical view]
SMART	SM00986. UDG. 1 hit. [Graphical view]
SUPFAM	SSF52141. UDNA_glycsylseSF. 1 hit.
TIGRFAMs	TIGR00628. ung. 1 hit.
PROSITE	PS00130. U_DNA_GLYCOSYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UNG_CAMC1

Accession

Primary (citable) accession number: A7ZAZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program