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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Manganese 1UniRule annotation1
Metal bindingi13Manganese 1UniRule annotation1
Metal bindingi15Manganese 2UniRule annotation1
Metal bindingi75Manganese 1UniRule annotation1
Metal bindingi75Manganese 2UniRule annotation1
Metal bindingi97Manganese 2UniRule annotation1
Metal bindingi149Manganese 2UniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:RBAM_037630
OrganismiBacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001120 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000123061 – 309Probable manganese-dependent inorganic pyrophosphataseAdd BLAST309

Interactioni

Protein-protein interaction databases

STRINGi326423.RBAM_037630.

Structurei

3D structure databases

ProteinModelPortaliA7ZAR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ZAR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKILIFGHQ NPDTDTICSA IAYADLKNKL GFNAEPVRLG QVNGETQYAL
60 70 80 90 100
DYFKQESPRL VETAANEVNG VILVDHNERQ QSIKDIEDVQ VLEVIDHHRI
110 120 130 140 150
ANFETAEPLY YRAEPVGCTA TILNKMYKEN NVKIEKEIAG LMLSAIISDS
160 170 180 190 200
LLFKSPTCTE QDIAAAKELA EIAGVDAEEY GLNMLKAGAD LSKKTVEELI
210 220 230 240 250
SLDAKEFTLG SKKVEIAQVN TVDIEDVKKR QPELEAALSK VIAEKNLDLF
260 270 280 290 300
LLVITDILEN DSLALAIGDQ ASKVEKAFNV TLENNTALLK GVVSRKKQVV

PVLTDAIAE
Length:309
Mass (Da):34,013
Last modified:October 23, 2007 - v1
Checksum:i3DAC03D8C000F798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS76088.1.
RefSeqiWP_004393053.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS76088; ABS76088; RBAM_037630.
KEGGibay:RBAM_037630.
PATRICi18752754. VBIBacAmy31356_3819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS76088.1.
RefSeqiWP_004393053.1. NC_009725.1.

3D structure databases

ProteinModelPortaliA7ZAR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326423.RBAM_037630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS76088; ABS76088; RBAM_037630.
KEGGibay:RBAM_037630.
PATRICi18752754. VBIBacAmy31356_3819.

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_BACVZ
AccessioniPrimary (citable) accession number: A7ZAR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.