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Protein

5-deoxy-glucuronate isomerase

Gene

iolB

Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).UniRule annotation

Catalytic activityi

5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate.UniRule annotation

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in step 4 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase (iolG)
  2. Inosose dehydratase (iolE)
  3. 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD)
  4. 5-deoxy-glucuronate isomerase (iolB)
  5. 5-dehydro-2-deoxygluconokinase (iolC)
  6. 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase (iolJ)
  7. Malonate-semialdehyde dehydrogenase (iolA)
This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00076; UER00920

Names & Taxonomyi

Protein namesi
Recommended name:
5-deoxy-glucuronate isomeraseUniRule annotation (EC:5.3.1.30UniRule annotation)
Short name:
5DG isomeraseUniRule annotation
Gene namesi
Name:iolBUniRule annotation
Ordered Locus Names:RBAM_036770
OrganismiBacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group
Proteomesi
  • UP000001120 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003523821 – 2715-deoxy-glucuronate isomeraseAdd BLAST271

Structurei

3D structure databases

ProteinModelPortaliA7ZAI0
SMRiA7ZAI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isomerase IolB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3718 LUCA
HOGENOMiHOG000239754
KOiK03337
OMAiHGYDLYY

Family and domain databases

Gene3Di2.60.120.10, 2 hits
HAMAPiMF_01673 IolB, 1 hit
InterProiView protein in InterPro
IPR024203 Deoxy-glucuronate_isom_IolB
IPR023770 IolB_Bacilli
IPR021120 KduI/IolB_isomerase
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR39193 PTHR39193, 1 hit
PfamiView protein in Pfam
PF04962 KduI, 1 hit
PIRSFiPIRSF036628 IolB, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR04378 myo_inos_iolB, 1 hit

Sequencei

Sequence statusi: Complete.

A7ZAI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLLRKPQA DEISQGVNII HDVTSANSDL KYVGFKVVDL TPGSAYTEDL
60 70 80 90 100
KKTECCIVAV TGKITVTDYD QTFESIGTRE SVFERKPTDS VYVSNDRSFE
110 120 130 140 150
ITAVSGARVA LCYSPSEHQL PTKLIKAEDN GVEHRGKLAN KRTVHNILPD
160 170 180 190 200
SDPSANSLLV VEVYTDSGNW SSYPPHKHDQ DNLPAESFLE ETYYHETDPP
210 220 230 240 250
QGFVFQRVYT DDRSIDETMT AENENVVIVP AGYHPVGVPD GYTSYYLNVM
260 270
AGPTRKWKFH NDPAHEWILE R
Length:271
Mass (Da):30,443
Last modified:October 23, 2007 - v1
Checksum:i8679BDBD7F3A1643
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA Translation: ABS76006.1
RefSeqiWP_012118847.1, NC_009725.1

Genome annotation databases

EnsemblBacteriaiABS76006; ABS76006; RBAM_036770
KEGGibay:RBAM_036770

Similar proteinsi

Entry informationi

Entry nameiIOLB_BACVZ
AccessioniPrimary (citable) accession number: A7ZAI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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