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Protein

5-deoxy-glucuronate isomerase

Gene

iolB

Organism
Bacillus methylotrophicus (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).UniRule annotation

Catalytic activityi

5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate.UniRule annotation

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in step 4 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase (iolG)
  2. Inosose dehydratase (iolE)
  3. 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD)
  4. 5-deoxy-glucuronate isomerase (iolB)
  5. 5-dehydro-2-deoxygluconokinase (iolC)
  6. 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase (iolJ)
  7. Methylmalonate semialdehyde dehydrogenase [acylating] (iolA)
This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-3674-MONOMER.
UniPathwayiUPA00076; UER00920.

Names & Taxonomyi

Protein namesi
Recommended name:
5-deoxy-glucuronate isomeraseUniRule annotation (EC:5.3.1.30UniRule annotation)
Short name:
5DG isomeraseUniRule annotation
Gene namesi
Name:iolBUniRule annotation
Ordered Locus Names:RBAM_036770
OrganismiBacillus methylotrophicus (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001120 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2712715-deoxy-glucuronate isomerasePRO_0000352382Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326423.RBAM_036770.

Structurei

3D structure databases

ProteinModelPortaliA7ZAI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isomerase IolB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3718. LUCA.
HOGENOMiHOG000239754.
KOiK03337.
OMAiEGCTSSY.
OrthoDBiEOG6XQ3HV.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_01673. IolB.
InterProiIPR024203. Deoxy-glucuronate_isom_IolB.
IPR023770. IolB_Bacilli.
IPR021120. KduI/IolB_isomerase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF036628. IolB. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR04378. myo_inos_iolB. 1 hit.

Sequencei

Sequence statusi: Complete.

A7ZAI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLLRKPQA DEISQGVNII HDVTSANSDL KYVGFKVVDL TPGSAYTEDL
60 70 80 90 100
KKTECCIVAV TGKITVTDYD QTFESIGTRE SVFERKPTDS VYVSNDRSFE
110 120 130 140 150
ITAVSGARVA LCYSPSEHQL PTKLIKAEDN GVEHRGKLAN KRTVHNILPD
160 170 180 190 200
SDPSANSLLV VEVYTDSGNW SSYPPHKHDQ DNLPAESFLE ETYYHETDPP
210 220 230 240 250
QGFVFQRVYT DDRSIDETMT AENENVVIVP AGYHPVGVPD GYTSYYLNVM
260 270
AGPTRKWKFH NDPAHEWILE R
Length:271
Mass (Da):30,443
Last modified:October 23, 2007 - v1
Checksum:i8679BDBD7F3A1643
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS76006.1.
RefSeqiWP_012118847.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS76006; ABS76006; RBAM_036770.
KEGGibay:RBAM_036770.
PATRICi18752584. VBIBacAmy31356_3738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS76006.1.
RefSeqiWP_012118847.1. NC_009725.1.

3D structure databases

ProteinModelPortaliA7ZAI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326423.RBAM_036770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS76006; ABS76006; RBAM_036770.
KEGGibay:RBAM_036770.
PATRICi18752584. VBIBacAmy31356_3738.

Phylogenomic databases

eggNOGiCOG3718. LUCA.
HOGENOMiHOG000239754.
KOiK03337.
OMAiEGCTSSY.
OrthoDBiEOG6XQ3HV.

Enzyme and pathway databases

UniPathwayiUPA00076; UER00920.
BioCyciBAMY326423:GCM4-3674-MONOMER.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_01673. IolB.
InterProiIPR024203. Deoxy-glucuronate_isom_IolB.
IPR023770. IolB_Bacilli.
IPR021120. KduI/IolB_isomerase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF036628. IolB. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR04378. myo_inos_iolB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 23117 / BGSC 10A6 / FZB42.

Entry informationi

Entry nameiIOLB_BACMF
AccessioniPrimary (citable) accession number: A7ZAI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 23, 2007
Last modified: November 11, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.