A7ZAH5 (IOLG_BACA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
EC=1.1.1.18
EC=1.1.1.n6

Alternative name(s):
Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
Short name=MI 2-dehydrogenase/DCI 3-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	RBAM_036720

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 D-chiro-inositol + NAD+ = 2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP MF_01671		PRO_0000352554

Sequences

	Sequence		Length	Mass (Da)
	A7ZAH5 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 7C48F4C22FBED5DA	FASTA	344	38,131
	10 20 30 40 50 60 MNLRIGVIGT GAIGKEHINR ITNKLSGAEI TAVTDVNQEA AQQTVQDFNL NASVYPDDDS 70 80 90 100 110 120 LLAAENVDAV LVTSWGPAHE SSVLKAIQHG KHVFCEKPLA TTAEGCMRIV EEEMKTGKRL 130 140 150 160 170 180 VQVGFMRRYD SGYVQLKEAI DNRVVGEPLM IHCAHRNPTV ASNYSTEMAV VDTLVHEIDV 190 200 210 220 230 240 LHWLVNDDYE SVQVIYPKKS KNALPHLKDP QMVIIETKGG IVINAEIYVN CKYGYDIQCE 250 260 270 280 290 300 IVGEDGIIKL PEPSSISLRK EGKFSTDILM DWQRRFVAAY DVEIQDFIDS IRNKGEVSGP 310 320 330 340 TAWDGYIAAV TTDACVKAQE SGQKEPVALQ EKPAFYQSFT TVNK

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FZB42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000560 Genomic DNA. Translation: ABS76001.1.
RefSeq	YP_001423232.1. NC_009725.1.
3D structure databases
ProteinModelPortal	A7ZAH5.
ModBase	Search...
Protein-protein interaction databases
STRING	A7ZAH5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000004278; EBBACP00000004156; EBBACG00000004270.
GeneID	5462665.
GenomeReviews	Gene locus RBAM_036720 in contig CP000560_GR.
KEGG	bay:RBAM_036720.
PATRIC	18752574. VBIBacAmy31356_3733.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
GeneTree	EBGT00050000000829.
HOGENOM	HBG612336.
OMA	HINRITN.
ProtClustDB	CLSK873287.
Enzyme and pathway databases
BioCyc	BAMY326423:RBAM_036720-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_BACA2

Accession

Primary (citable) accession number: A7ZAH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program