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A7Z8C3 (GUAC_BACA2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP reductase

EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:RBAM_029180
OrganismBacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]
Taxonomic identifier326423 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillus

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326GMP reductase HAMAP MF_01511
PRO_1000024490

Regions

Nucleotide binding204 – 22724NADP Potential

Sites

Active site1751Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
A7Z8C3 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: A2FD907375378B9A

FASTA32635,852
        10         20         30         40         50         60 
MENVFDYEDI QLIPAKCIVD SRSECDTSVT LGGHTFKLPV VPANMQTIID ENIAAWLAEN 

        70         80         90        100        110        120 
GYFYIMHRFE PEKRLAFVQD MKARGLISSI SVGVKENDYE FIRELKAQEL VPDYITIDIA 

       130        140        150        160        170        180 
HGHSNAVISM IQFIKEHVPE SFVIAGNVGT PEAVRELERA GADATKVGIG PGKVCITKIK 

       190        200        210        220        230        240 
TGFGTGGWQL AALRWCAKAA SKPIIADGGI RTHGDIAKSI RFGASMVMIG SLFAGHEESP 

       250        260        270        280        290        300 
GQTIEIDGKL YKEYFGSASE FQKGEKKNVE GKKMHVEHKG SLQDTLVEME QDLQSSISYA 

       310        320 
GGNTLEAIRN VDYVIVKNSI FNGDRF 

« Hide

References

[1]"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42."
Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R.
Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FZB42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000560 Genomic DNA. Translation: ABS75249.1.
RefSeqYP_001422480.1. NC_009725.1.

3D structure databases

ProteinModelPortalA7Z8C3.
SMRA7Z8C3. Positions 1-321.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7Z8C3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000004819; EBBACP00000004697; EBBACG00000004811.
GeneID5460081.
GenomeReviewsGene locus RBAM_029180 in contig CP000560_GR.
KEGGbay:RBAM_029180.
PATRIC18751018. VBIBacAmy31356_2956.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0516.
GeneTreeEBGT00050000000995.
HOGENOMHBG298985.
OMAPDYITID.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycBAMY326423:RBAM_029180-MONOMER.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_BACA2
AccessionPrimary (citable) accession number: A7Z8C3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families