Reviewed,
UniProtKB/Swiss-Prot A7Z800 (LUXS_BACA2)
Last modified
November 3, 2009.
Version 15.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: S-ribosylhomocysteine lyase EC=4.4.1.21 Alternative name(s): Autoinducer-2 production protein luxS AI-2 synthesis protein | ||||
| Gene names |
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| Organism | Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 326423 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 157 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. |
| Catalytic activity | S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. HAMAP MF_00091 |
| Cofactor | Binds 1 iron ion per subunit By similarity. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the luxS family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Autoinducer synthesis Quorum sensing |
| Ligand | Iron Metal-binding |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | quorum sensing Inferred from electronic annotation. Source: HAMAP |
| Molecular function | S-ribosylhomocysteine lyase activity Inferred from electronic annotation. Source: HAMAP iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 157 | 157 | S-ribosylhomocysteine lyase HAMAP MF_00091 | PRO_1000004836 | |||||
Sites | |||||||||
| Metal binding | 54 | 1 | Iron By similarity | ||||||
| Metal binding | 58 | 1 | Iron By similarity | ||||||
| Metal binding | 126 | 1 | Iron By similarity | ||||||
Sequences
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References
| [1] | "Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000560 Genomic DNA. Translation: ABS75126.1. | |
| RefSeq | YP_001422357.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A7Z800. |
Genome annotation databases | |
| GeneID | 5463170. |
| GenomeReviews | Gene locus RBAM_027680 in contig CP000560_GR. |
| KEGG | bay:RBAM_027680. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | VRIAKTM. |
Family and domain databases | |
| HAMAP | MF_00091. [Tree] |
| InterPro | IPR003815. S-ribosylhomocysteinase. [Graphical view] |
| Gene3D | G3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit. |
| Pfam | PF02664. LuxS. 1 hit. [Graphical view] |
| PIRSF | PIRSF006160. AI2. 1 hit. |
| PRINTS | PR01487. LUXSPROTEIN. |
| ProDom | PD013172. LuxS. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Entry information
| Entry name | LUXS_BACA2 | ||||||||
| Accession | Primary (citable) accession number: A7Z800 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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