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A7Z7V7

- SYL_BACA2

UniProt

A7Z7V7 - SYL_BACA2

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAMY326423:GCM4-2723-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RBAM_027250
    OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
    Taxonomic identifieri326423 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001120: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 804804Leucine--tRNA ligasePRO_1000009291Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326423.RBAM_027250.

    Structurei

    3D structure databases

    ProteinModelPortaliA7Z7V7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7Z7V7-1 [UniParc]FASTAAdd to Basket

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    MSFQHEKIEK KWQNYWLDHK TFAVSEENDK PKFYALDMFP YPSGAGLHVG    50
    HPEGYTATDI LSRMRRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT 100
    KQNIDNFRRQ IQSLGFSYDW DREINTTDPD YYKWTQWIFT KLYEKGLAYV 150
    DEVPVNWCPA LGTVLANEEV IDGKSERGGH PVERRPMRQW MLKITAYADR 200
    LLEDLEDLDW PESIKDMQRN WIGRSEGANV HFAIDGTDDT FTVFTTRPDT 250
    LFGAAYAVLA PEHELVEAIT TPEQKEAVDA YVKEVQAKSD LERTDLAKTK 300
    TGVFTGAYAV NPANGEKLPI WIADYVLASY GTGAVMAVPA HDERDFEFAK 350
    VFSLPVKEVV KGGNTEEEAY TGDGEHVNSG FLNGLKKAEA IEKMIAWLEE 400
    TKNGEKKVTY RLRDWLFSRQ RYWGEPIPVI HWEDGTSTAV PAEELPLILP 450
    KTDEIKPSGT GESPLANIKE WVEVTDPETG KKGRRETNTM PQWAGSCWYF 500
    LRFIDPKNPD QLASPEKLDK WLPVDIYIGG AEHAVLHLLY ARFWHKFLYD 550
    IGVVPTKEPF QKLYNQGMIL GENNEKMSKS RGNVVNPDEI VASHGADTLR 600
    LYEMFMGPLD ASIAWSESGL DGARRFLDRV WRLFIEENGE LTGKVTEGAG 650
    ETLERVYHET VMKVTENFEA LRFNTGISQL MVFINEAYKA NELPREYIEG 700
    FVKLLSPIAP HLAEELWEKL GHEGSIAYEA WPAYDESKLV DDEVEIVVQL 750
    NGKVKAKLMV PADADKAALE QLAQADEKVK EQLEGKTIRK IIAVPGKLVN 800
    IVAN 804
    Length:804
    Mass (Da):91,270
    Last modified:October 23, 2007 - v1
    Checksum:i37CC64858244D4EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000560 Genomic DNA. Translation: ABS75083.1.
    RefSeqiYP_001422314.1. NC_009725.1.

    Genome annotation databases

    EnsemblBacteriaiABS75083; ABS75083; RBAM_027250.
    GeneIDi5462049.
    KEGGibay:RBAM_027250.
    PATRICi18750606. VBIBacAmy31356_2776.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000560 Genomic DNA. Translation: ABS75083.1 .
    RefSeqi YP_001422314.1. NC_009725.1.

    3D structure databases

    ProteinModelPortali A7Z7V7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326423.RBAM_027250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS75083 ; ABS75083 ; RBAM_027250 .
    GeneIDi 5462049.
    KEGGi bay:RBAM_027250.
    PATRICi 18750606. VBIBacAmy31356_2776.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BAMY326423:GCM4-2723-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 23117 / BGSC 10A6 / FZB42.

    Entry informationi

    Entry nameiSYL_BACA2
    AccessioniPrimary (citable) accession number: A7Z7V7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3