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A7Z7V7

- SYL_BACA2

UniProt

A7Z7V7 - SYL_BACA2

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Protein
Leucine--tRNA ligase
Gene
leuS, RBAM_027250
Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-2723-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:RBAM_027250
OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001120: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligaseUniRule annotation
PRO_1000009291Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326423.RBAM_027250.

Structurei

3D structure databases

ProteinModelPortaliA7Z7V7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7Z7V7-1 [UniParc]FASTAAdd to Basket

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MSFQHEKIEK KWQNYWLDHK TFAVSEENDK PKFYALDMFP YPSGAGLHVG    50
HPEGYTATDI LSRMRRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT 100
KQNIDNFRRQ IQSLGFSYDW DREINTTDPD YYKWTQWIFT KLYEKGLAYV 150
DEVPVNWCPA LGTVLANEEV IDGKSERGGH PVERRPMRQW MLKITAYADR 200
LLEDLEDLDW PESIKDMQRN WIGRSEGANV HFAIDGTDDT FTVFTTRPDT 250
LFGAAYAVLA PEHELVEAIT TPEQKEAVDA YVKEVQAKSD LERTDLAKTK 300
TGVFTGAYAV NPANGEKLPI WIADYVLASY GTGAVMAVPA HDERDFEFAK 350
VFSLPVKEVV KGGNTEEEAY TGDGEHVNSG FLNGLKKAEA IEKMIAWLEE 400
TKNGEKKVTY RLRDWLFSRQ RYWGEPIPVI HWEDGTSTAV PAEELPLILP 450
KTDEIKPSGT GESPLANIKE WVEVTDPETG KKGRRETNTM PQWAGSCWYF 500
LRFIDPKNPD QLASPEKLDK WLPVDIYIGG AEHAVLHLLY ARFWHKFLYD 550
IGVVPTKEPF QKLYNQGMIL GENNEKMSKS RGNVVNPDEI VASHGADTLR 600
LYEMFMGPLD ASIAWSESGL DGARRFLDRV WRLFIEENGE LTGKVTEGAG 650
ETLERVYHET VMKVTENFEA LRFNTGISQL MVFINEAYKA NELPREYIEG 700
FVKLLSPIAP HLAEELWEKL GHEGSIAYEA WPAYDESKLV DDEVEIVVQL 750
NGKVKAKLMV PADADKAALE QLAQADEKVK EQLEGKTIRK IIAVPGKLVN 800
IVAN 804
Length:804
Mass (Da):91,270
Last modified:October 23, 2007 - v1
Checksum:i37CC64858244D4EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000560 Genomic DNA. Translation: ABS75083.1.
RefSeqiYP_001422314.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS75083; ABS75083; RBAM_027250.
GeneIDi5462049.
KEGGibay:RBAM_027250.
PATRICi18750606. VBIBacAmy31356_2776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000560 Genomic DNA. Translation: ABS75083.1 .
RefSeqi YP_001422314.1. NC_009725.1.

3D structure databases

ProteinModelPortali A7Z7V7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326423.RBAM_027250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS75083 ; ABS75083 ; RBAM_027250 .
GeneIDi 5462049.
KEGGi bay:RBAM_027250.
PATRICi 18750606. VBIBacAmy31356_2776.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BAMY326423:GCM4-2723-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 23117 / BGSC 10A6 / FZB42.

Entry informationi

Entry nameiSYL_BACA2
AccessioniPrimary (citable) accession number: A7Z7V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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