Reviewed, UniProtKB/Swiss-Prot A7Z7L9 (ARLY_BACA2)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	RBAM_026370

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Argininosuccinate lyase HAMAP MF_00006		PRO_1000000451

Sequences

	Sequence		Length	Mass (Da)
	A7Z7L9-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 98AC361FA5A2D719	FASTA	458	51,726
	10 20 30 40 50 60 MKKLWGGRFQ KTPEKWVDEF GASITFDQNL VKEDITGSLA HAAMLKKCGI LTEEEEGAIR 70 80 90 100 110 120 QGLQTLLQKA EEGTLEFSVD YEDIHLNIEK MLIEEIGPLG GKLHTGRSRN DQVATDMHLY 130 140 150 160 170 180 LKDHVSHIIV LIEQFQKALI EKAEANVETI LPGYTHLQRA QPISFAHHLL AYFWMLERDK 190 200 210 220 230 240 ERFRDAMKRI NISPLGCGAL AGTTFPIDRN YSAELLGFDS IYENSLDGVS DRDFILEFLS 250 260 270 280 290 300 GSSMLMMHLS RLSEEIILWC SQEFRFIELD DTYATGSSMM PQKKNPDMAE LIRGKTGRVY 310 320 330 340 350 360 GDMMGLFTIM KGLPLAYNKD LQEDKEGMFD TVKTVEGSLQ IFTGMIETMK VNKDIMKQAT 370 380 390 400 410 420 KQDFSNATEL ADYLAKKGMP FREAHEVVGK LVYSCIEKGI YLSDMAFEEF LQASSLFEED 430 440 450 IYTVLDPHHA VEKRMSAGGT GFQQVEQALV KAKACAGI

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000560 Genomic DNA. Translation: ABS74995.1.
RefSeq	YP_001422226.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7Z7L9.
Genome annotation databases
GeneID	5461721.
GenomeReviews	Gene locus RBAM_026370 in contig CP000560_GR.
KEGG	bay:RBAM_026370.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ATDTRLY.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BACA2

Accession

Primary (citable) accession number: A7Z7L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)