A7Z7A2 (GSA2_BACA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 2
Short name=GSA 2
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 2
Short name=GSA-AT 2

Gene names

Name:	hemL2
Ordered Locus Names:	RBAM_025180

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group › Bacillus amyloliquefaciens › Bacillus amyloliquefaciens subsp. plantarum

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Glutamate-1-semialdehyde 2,1-aminomutase 2 HAMAP-Rule MF_00375		PRO_0000382258
Amino acid modifications
	Modified residue	268	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7Z7A2 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 002323C35CF15D82	FASTA	429	46,139
	10 20 30 40 50 60 MRSYEKSKAA FKEAQKLMPG GVNSPVRAFK SVDMDPIFMQ RGKGSKIFDI DGNEYIDYVL 70 80 90 100 110 120 SWGPLILGHT NDRVVESLKK VAENGTSFGA STEVENELAK LVIDRVPSVE IVRMVSSGTE 130 140 150 160 170 180 ATMSALRLAR GYTGRNKILK FEGCYHGHGD SLLIKAGSGV ATLGLPDSPG VPEGIAMNTI 190 200 210 220 230 240 TVPYNDLESV ALAFREYGED IAGVIVEPVA GNMGVVPPQE GFLQGLRDMT EQYGALLIFD 250 260 270 280 290 300 EVMTGFRVDY NCAQGYFGVT PDLTCLGKVI GGGLPVGAYG GKADIMERIA PSGPIYQAGT 310 320 330 340 350 360 LSGNPLAMTA GLETLQQLTP ESYQEFVKKG DMLEEGISKA AAAHGIPHTF NRAGSMIGFF 370 380 390 400 410 420 FTNEPVINYE AAKSSDLKLF AKYYKGMADA GVFLPPSQFE GLFLSTAHTM EDIENTIQAA EKVFQAISR

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FZB42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000560 Genomic DNA. Translation: ABS74878.1.
RefSeq	YP_001422109.1. NC_009725.1.
3D structure databases
ProteinModelPortal	A7Z7A2.
SMR	A7Z7A2. Positions 5-426.
ModBase	Search...
Protein-protein interaction databases
STRING	326423.RBAM_025180.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABS74878; ABS74878; RBAM_025180.
GeneID	5460782.
KEGG	bay:RBAM_025180.
PATRIC	18750154. VBIBacAmy31356_2552.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	FNGNPIS.
ProtClustDB	PRK00062.
Enzyme and pathway databases
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA2_BACA2

Accession

Primary (citable) accession number: A7Z7A2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program